N-acetylmannosamine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
N-acetylmannosamine
Accession Number
DB12536
Type
Small Molecule
Groups
Investigational
Description

N-acetylmannosamine is under investigation for the other of GNE Myopathy.

Structure
Thumb
Synonyms
  • MANNAC
Categories
UNII
X80PR7P73R
CAS number
3615-17-6
Weight
Average: 221.2078
Monoisotopic: 221.089937217
Chemical Formula
C8H15NO6
InChI Key
MBLBDJOUHNCFQT-WCTZXXKLSA-N
InChI
InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m1/s1
IUPAC Name
N-[(2S,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl]acetamide
SMILES
[H][C@@](O)(CO)[C@@]([H])(O)[C@]([H])(O)[C@]([H])(NC(C)=O)C=O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
Human Metabolome Database
HMDB0062500
PubChem Compound
65150
PubChem Substance
347828762
ChemSpider
58659
ChEBI
17122
HET
MN9
Wikipedia
N-Acetylmannosamine
PDB Entries
4bwl / 4woz / 6ppz

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentGNE Myopathy / Hereditary Inclusion Body Myopathy (HIBM)1
2CompletedTreatmentGNE Myopathy1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility148.0 mg/mLALOGPS
logP-2.1ALOGPS
logP-3.9ChemAxon
logS-0.18ALOGPS
pKa (Strongest Acidic)11.56ChemAxon
pKa (Strongest Basic)-1.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area127.09 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity48.45 m3·mol-1ChemAxon
Polarizability20.74 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - GC-MS (4 TMS)GC-MSsplash10-00di-1910000000-c54e9f9969c7d963036f
GC-MS Spectrum - GC-MS (1 MEOX; 5 TMS)GC-MSsplash10-0pvi-1951000000-56398608d2dd4355e1f6
GC-MS Spectrum - GC-MS (1 MEOX; 4 TMS)GC-MSsplash10-0kw0-3940000000-02993315f1b1a700b7ec
GC-MS Spectrum - GC-MS (1 MEOX; 5 TMS)GC-MSsplash10-0pvi-2941000000-c2e3ada4d3e27dc6890a
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as hexoses. These are monosaccharides in which the sugar unit is a is a six-carbon containing moeity.
Kingdom
Organic compounds
Super Class
Organic oxygen compounds
Class
Organooxygen compounds
Sub Class
Carbohydrates and carbohydrate conjugates
Direct Parent
Hexoses
Alternative Parents
Aminosaccharides / Beta-hydroxy aldehydes / Acetamides / Secondary carboxylic acid amides / Secondary alcohols / Polyols / Primary alcohols / Organopnictogen compounds / Organonitrogen compounds / Organic oxides
show 1 more
Substituents
Hexose monosaccharide / Amino saccharide / Beta-hydroxy aldehyde / Acetamide / Carboxamide group / Secondary alcohol / Secondary carboxylic acid amide / Carboxylic acid derivative / Polyol / Aldehyde
show 9 more
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 16:45 / Updated on September 02, 2019 19:42