Sisomicin
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Sisomicin
- DrugBank Accession Number
- DB12604
- Background
Sisomicin has been used in trials studying the treatment of Pyoderma.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 447.5264
Monoisotopic: 447.269298563 - Chemical Formula
- C19H37N5O7
- Synonyms
- Sisomicin
- External IDs
- SCH 13475
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbacavir Abacavir may decrease the excretion rate of Sisomicin which could result in a higher serum level. Aceclofenac Aceclofenac may decrease the excretion rate of Sisomicin which could result in a higher serum level. Acemetacin Acemetacin may decrease the excretion rate of Sisomicin which could result in a higher serum level. Acenocoumarol The risk or severity of bleeding can be increased when Sisomicin is combined with Acenocoumarol. Acetaminophen Acetaminophen may decrease the excretion rate of Sisomicin which could result in a higher serum level. - Food Interactions
- Not Available
Categories
- ATC Codes
- J01GB08 — Sisomicin
- Drug Categories
- Agents that produce neuromuscular block (indirect)
- Aminoglycoside Antibacterials
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antibacterials for Systemic Use
- Antiinfectives for Systemic Use
- Carbohydrates
- Drugs that are Mainly Renally Excreted
- Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index
- Enzyme Inhibitors
- Gentamicins
- Glycosides
- Narrow Therapeutic Index Drugs
- Nephrotoxic agents
- Protein Synthesis Inhibitors
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as aminocyclitol glycosides. These are organic compounds containing an amicocyclitol moiety glycosidically linked to a carbohydrate moiety. There are two major classes of aminoglycosides containing a 2-streptamine core. They are called 4,5- and 4,6-disubstituted 2-deoxystreptamines.
- Kingdom
- Organic compounds
- Super Class
- Organic oxygen compounds
- Class
- Organooxygen compounds
- Sub Class
- Carbohydrates and carbohydrate conjugates
- Direct Parent
- Aminocyclitol glycosides
- Alternative Parents
- O-glycosyl compounds / Aminocyclitols and derivatives / Cyclohexylamines / Cyclohexanols / Oxanes / Monosaccharides / Tertiary alcohols / 1,2-aminoalcohols / Oxacyclic compounds / Dialkylamines show 4 more
- Substituents
- 1,2-aminoalcohol / Acetal / Alcohol / Aliphatic heteromonocyclic compound / Amine / Amino cyclitol glycoside / Aminocyclitol or derivatives / Cyclic alcohol / Cyclitol or derivatives / Cyclohexanol show 17 more
- Molecular Framework
- Aliphatic heteromonocyclic compounds
- External Descriptors
- monosaccharide derivative, aminoglycoside antibiotic, amino cyclitol glycoside, beta-L-arabinoside (CHEBI:9169)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- X55XSL74YQ
- CAS number
- 32385-11-8
- InChI Key
- URWAJWIAIPFPJE-YFMIWBNJSA-N
- InChI
- InChI=1S/C19H37N5O7/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17/h3,9-18,24-27H,4-7,20-23H2,1-2H3/t9-,10+,11-,12+,13-,14-,15+,16-,17-,18-,19+/m1/s1
- IUPAC Name
- (2R,3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol
- SMILES
- [H][C@@]1(N)CC=C(CN)O[C@]1([H])O[C@]1([H])[C@@]([H])(N)C[C@@]([H])(N)[C@]([H])(O[C@@]2([H])OC[C@](C)(O)[C@]([H])(NC)[C@@]2([H])O)[C@@]1([H])O
References
- General References
- Not Available
- External Links
- KEGG Compound
- C00494
- PubChem Compound
- 36119
- PubChem Substance
- 347828820
- ChemSpider
- 33222
- 9806
- ChEBI
- 9169
- ChEMBL
- CHEMBL221886
- ZINC
- ZINC000056870809
- PDBe Ligand
- SIS
- Wikipedia
- Sisomicin
- PDB Entries
- 4f8u / 4f8v / 5c4l / 5u08 / 6bbz / 6bc3 / 6bc7 / 6cap / 6car / 6mb4 … show 7 more
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 15.6 mg/mL ALOGPS logP -2 ALOGPS logP -4.3 Chemaxon logS -1.5 ALOGPS pKa (Strongest Acidic) 12.55 Chemaxon pKa (Strongest Basic) 9.74 Chemaxon Physiological Charge 5 Chemaxon Hydrogen Acceptor Count 12 Chemaxon Hydrogen Donor Count 8 Chemaxon Polar Surface Area 213.72 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 110.32 m3·mol-1 Chemaxon Polarizability 46.67 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 215.174783 predictedDarkChem Lite v0.1.0 [M-H]- 189.77202 predictedDeepCCS 1.0 (2019) [M+H]+ 215.776783 predictedDarkChem Lite v0.1.0 [M+H]+ 191.49544 predictedDeepCCS 1.0 (2019) [M+Na]+ 214.900783 predictedDarkChem Lite v0.1.0 [M+Na]+ 197.79118 predictedDeepCCS 1.0 (2019)
Drug created at October 20, 2016 23:10 / Updated at February 21, 2021 18:53