Sisomicin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Sisomicin
Accession Number
DB12604
Type
Small Molecule
Groups
Investigational
Description

Sisomicin has been used in trials studying the treatment of Pyoderma.

Structure
Thumb
Synonyms
Not Available
External IDs
SCH 13475
Categories
UNII
X55XSL74YQ
CAS number
32385-11-8
Weight
Average: 447.5264
Monoisotopic: 447.269298563
Chemical Formula
C19H37N5O7
InChI Key
URWAJWIAIPFPJE-YFMIWBNJSA-N
InChI
InChI=1S/C19H37N5O7/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17/h3,9-18,24-27H,4-7,20-23H2,1-2H3/t9-,10+,11-,12+,13-,14-,15+,16-,17-,18-,19+/m1/s1
IUPAC Name
(2R,3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol
SMILES

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AceclofenacAceclofenac may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
AcemetacinAcemetacin may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
AcetyldigitoxinThe serum concentration of Acetyldigitoxin can be decreased when it is combined with Sisomicin.Approved
AcetyldigoxinThe serum concentration of Acetyldigoxin can be decreased when it is combined with Sisomicin.Experimental
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Vet Approved
AdapaleneAdapalene may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
AlclofenacAlclofenac may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Withdrawn
AlcuroniumSisomicin may increase the respiratory depressant activities of Alcuronium.Experimental
Alendronic acidSisomicin may increase the hypocalcemic activities of Alendronic acid.Approved
AlminoprofenAlminoprofen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
AmdinocillinThe serum concentration of Sisomicin can be decreased when it is combined with Amdinocillin.Withdrawn
AmoxicillinThe serum concentration of Sisomicin can be decreased when it is combined with Amoxicillin.Approved, Vet Approved
Amphotericin BAmphotericin B may increase the nephrotoxic activities of Sisomicin.Approved, Investigational
AmpicillinThe serum concentration of Sisomicin can be decreased when it is combined with Ampicillin.Approved, Vet Approved
AndrographolideAndrographolide may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
AnisodamineAnisodamine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
AntipyrineAntipyrine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
ApocyninApocynin may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
ApremilastApremilast may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational
AspoxicillinThe serum concentration of Sisomicin can be decreased when it is combined with Aspoxicillin.Experimental
AtracuriumSisomicin may increase the respiratory depressant activities of Atracurium.Experimental
Atracurium besylateSisomicin may increase the respiratory depressant activities of Atracurium besylate.Approved
AzapropazoneAzapropazone may decrease the excretion rate of Sisomicin which could result in a higher serum level.Withdrawn
AzelastineAzelastine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
AzidocillinThe serum concentration of Sisomicin can be decreased when it is combined with Azidocillin.Approved
AzlocillinThe serum concentration of Sisomicin can be decreased when it is combined with Azlocillin.Approved
BacampicillinThe serum concentration of Sisomicin can be decreased when it is combined with Bacampicillin.Approved
BalsalazideBalsalazide may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational
BCG vaccineThe therapeutic efficacy of BCG vaccine can be decreased when used in combination with Sisomicin.Investigational
BendazacBendazac may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
BenorilateBenorilate may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
BenoxaprofenBenoxaprofen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Withdrawn
Benzathine benzylpenicillinThe serum concentration of Sisomicin can be decreased when it is combined with Benzathine benzylpenicillin.Approved, Vet Approved
BenzylpenicillinThe serum concentration of Sisomicin can be decreased when it is combined with Benzylpenicillin.Approved, Vet Approved
Benzylpenicilloyl PolylysineThe serum concentration of Sisomicin can be decreased when it is combined with Benzylpenicilloyl Polylysine.Approved
BevoniumBevonium may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
Botulinum Toxin Type ASisomicin may increase the neuromuscular blocking activities of Botulinum Toxin Type A.Approved, Investigational
Botulinum Toxin Type BSisomicin may increase the neuromuscular blocking activities of Botulinum Toxin Type B.Approved
BromfenacBromfenac may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
BucillamineBucillamine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
BufexamacBufexamac may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
BumadizoneBumadizone may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
BumetanideThe risk or severity of adverse effects can be increased when Bumetanide is combined with Sisomicin.Approved
CapreomycinCapreomycin may increase the neuromuscular blocking activities of Sisomicin.Approved
Carbaspirin calciumCarbaspirin calcium may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
CarbenicillinThe serum concentration of Sisomicin can be decreased when it is combined with Carbenicillin.Approved
Carbenicillin indanylThe serum concentration of Sisomicin can be decreased when it is combined with Carbenicillin indanyl.Approved
CarboplatinSisomicin may increase the ototoxic activities of Carboplatin.Approved
CarfecillinThe serum concentration of Sisomicin can be decreased when it is combined with Carfecillin.Experimental
CarprofenCarprofen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
CelecoxibCelecoxib may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational
ChloroquineChloroquine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Vet Approved
Choline magnesium trisalicylateCholine magnesium trisalicylate may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
CisatracuriumSisomicin may increase the respiratory depressant activities of Cisatracurium.Experimental
Cisatracurium besylateSisomicin may increase the respiratory depressant activities of Cisatracurium besylate.Approved
CisplatinCisplatin may increase the nephrotoxic activities of Sisomicin.Approved
Clodronic AcidSisomicin may increase the hypocalcemic activities of Clodronic Acid.Approved, Investigational, Vet Approved
ClonixinClonixin may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
CloxacillinThe serum concentration of Sisomicin can be decreased when it is combined with Cloxacillin.Approved, Vet Approved
ColistimethateSisomicin may increase the nephrotoxic activities of Colistimethate.Approved, Vet Approved
CurcuminCurcumin may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
CyclacillinThe serum concentration of Sisomicin can be decreased when it is combined with Cyclacillin.Approved
CyclosporineSisomicin may increase the nephrotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
CymarinThe serum concentration of Cymarin can be decreased when it is combined with Sisomicin.Experimental
D-LimoneneD-Limonene may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
DecamethoniumSisomicin may increase the respiratory depressant activities of Decamethonium.Approved
DeslanosideThe serum concentration of Deslanoside can be decreased when it is combined with Sisomicin.Approved
DiclofenacDiclofenac may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Vet Approved
DicloxacillinThe serum concentration of Sisomicin can be decreased when it is combined with Dicloxacillin.Approved, Vet Approved
DifenpiramideDifenpiramide may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
DiflunisalDiflunisal may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Sisomicin.Approved
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Sisomicin.Approved
Domoic AcidSisomicin may increase the respiratory depressant activities of Domoic Acid.Experimental
Doxacurium chlorideSisomicin may increase the respiratory depressant activities of Doxacurium chloride.Approved
DroxicamDroxicam may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
DuvelisibDuvelisib may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
E-6201E-6201 may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
EpicillinThe serum concentration of Sisomicin can be decreased when it is combined with Epicillin.Experimental
EpirizoleEpirizole may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Etacrynic acid is combined with Sisomicin.Approved
EtanerceptEtanercept may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational
EthenzamideEthenzamide may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
Etidronic acidSisomicin may increase the hypocalcemic activities of Etidronic acid.Approved
EtodolacEtodolac may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
EtoricoxibEtoricoxib may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational
Evening primrose oilEvening primrose oil may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
exisulindexisulind may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
FelbinacFelbinac may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
FenbufenFenbufen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
FenoprofenFenoprofen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
FentiazacFentiazac may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
FeprazoneFeprazone may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
Ferulic acidFerulic acid may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
FloctafenineFloctafenine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Withdrawn
FlucloxacillinThe serum concentration of Sisomicin can be decreased when it is combined with Flucloxacillin.Approved
FlunixinFlunixin may decrease the excretion rate of Sisomicin which could result in a higher serum level.Vet Approved
FlunoxaprofenFlunoxaprofen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
FlurbiprofenFlurbiprofen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational
FoscarnetFoscarnet may increase the nephrotoxic activities of Sisomicin.Approved
FurosemideThe risk or severity of adverse effects can be increased when Furosemide is combined with Sisomicin.Approved, Vet Approved
GallamineSisomicin may increase the respiratory depressant activities of Gallamine.Experimental
Gallamine TriethiodideSisomicin may increase the respiratory depressant activities of Gallamine Triethiodide.Approved
GitoformateThe serum concentration of Gitoformate can be decreased when it is combined with Sisomicin.Experimental
GuacetisalGuacetisal may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
HigenamineHigenamine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
IbandronateSisomicin may increase the hypocalcemic activities of Ibandronate.Approved, Investigational
IbuprofenIbuprofen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
IbuproxamIbuproxam may decrease the excretion rate of Sisomicin which could result in a higher serum level.Withdrawn
IcatibantIcatibant may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
Imidazole salicylateImidazole salicylate may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
IndobufenIndobufen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
IndomethacinIndomethacin may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational
IndoprofenIndoprofen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Withdrawn
IsoxicamIsoxicam may decrease the excretion rate of Sisomicin which could result in a higher serum level.Withdrawn
KebuzoneKebuzone may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
KetoprofenKetoprofen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Vet Approved
KetorolacKetorolac may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
Lanatoside CThe serum concentration of Lanatoside C can be decreased when it is combined with Sisomicin.Experimental
LeflunomideLeflunomide may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational
LisofyllineLisofylline may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
LonazolacLonazolac may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
LornoxicamLornoxicam may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
LoxoprofenLoxoprofen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
LumiracoxibLumiracoxib may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational
Magnesium salicylateMagnesium salicylate may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
MannitolMannitol may increase the nephrotoxic activities of Sisomicin.Approved, Investigational
MasoprocolMasoprocol may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
MecamylamineSisomicin may increase the neuromuscular blocking activities of Mecamylamine.Approved
Meclofenamic acidMeclofenamic acid may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Vet Approved
Mefenamic acidMefenamic acid may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
MeloxicamMeloxicam may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Vet Approved
MesalazineMesalazine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
MetamizoleMetamizole may decrease the excretion rate of Sisomicin which could result in a higher serum level.Withdrawn
MetampicillinThe serum concentration of Sisomicin can be decreased when it is combined with Metampicillin.Experimental
MeticillinThe serum concentration of Sisomicin can be decreased when it is combined with Meticillin.Approved
MetildigoxinThe serum concentration of Metildigoxin can be decreased when it is combined with Sisomicin.Experimental
MetocurineSisomicin may increase the respiratory depressant activities of Metocurine.Approved
Metocurine IodideSisomicin may increase the respiratory depressant activities of Metocurine Iodide.Withdrawn
MezlocillinThe serum concentration of Sisomicin can be decreased when it is combined with Mezlocillin.Approved
MivacuriumSisomicin may increase the respiratory depressant activities of Mivacurium.Approved
MizoribineMizoribine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
MofebutazoneMofebutazone may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
Mycophenolate mofetilMycophenolate mofetil may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational
Mycophenolic acidMycophenolic acid may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
NabumetoneNabumetone may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
NafamostatNafamostat may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational
NafcillinThe serum concentration of Sisomicin can be decreased when it is combined with Nafcillin.Approved
NaftifineNaftifine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
NaproxenNaproxen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Vet Approved
NeosaxitoxinSisomicin may increase the respiratory depressant activities of Neosaxitoxin.Investigational
NepafenacNepafenac may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
NifenazoneNifenazone may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
Niflumic AcidNiflumic Acid may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
NimesulideNimesulide may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Withdrawn
NitroaspirinNitroaspirin may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
OleandrinThe serum concentration of Oleandrin can be decreased when it is combined with Sisomicin.Experimental
OlopatadineOlopatadine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
OlsalazineOlsalazine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
OrgoteinOrgotein may decrease the excretion rate of Sisomicin which could result in a higher serum level.Vet Approved
OuabainThe serum concentration of Ouabain can be decreased when it is combined with Sisomicin.Approved
OxacillinThe serum concentration of Sisomicin can be decreased when it is combined with Oxacillin.Approved
OxaprozinOxaprozin may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
OxyphenbutazoneOxyphenbutazone may decrease the excretion rate of Sisomicin which could result in a higher serum level.Withdrawn
PamidronateSisomicin may increase the hypocalcemic activities of Pamidronate.Approved
PancuroniumSisomicin may increase the respiratory depressant activities of Pancuronium.Approved
ParecoxibParecoxib may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
ParthenolideParthenolide may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
PenamecillinThe serum concentration of Sisomicin can be decreased when it is combined with Penamecillin.Experimental
PenimepicyclineThe serum concentration of Sisomicin can be decreased when it is combined with Penimepicycline.Experimental
PeruvosideThe serum concentration of Peruvoside can be decreased when it is combined with Sisomicin.Experimental
PhenoxymethylpenicillinThe serum concentration of Sisomicin can be decreased when it is combined with Phenoxymethylpenicillin.Approved, Vet Approved
PhenylbutazonePhenylbutazone may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Vet Approved
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sisomicin.Approved
PimecrolimusPimecrolimus may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational
PipecuroniumSisomicin may increase the respiratory depressant activities of Pipecuronium.Approved
PiperacillinThe serum concentration of Sisomicin can be decreased when it is combined with Piperacillin.Approved
PiretanideThe risk or severity of adverse effects can be increased when Piretanide is combined with Sisomicin.Experimental
PirfenidonePirfenidone may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
PiroxicamPiroxicam may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational
PirprofenPirprofen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
PivampicillinThe serum concentration of Sisomicin can be decreased when it is combined with Pivampicillin.Approved
PivmecillinamThe serum concentration of Sisomicin can be decreased when it is combined with Pivmecillinam.Approved
PranoprofenPranoprofen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
Procaine benzylpenicillinThe serum concentration of Sisomicin can be decreased when it is combined with Procaine benzylpenicillin.Approved, Vet Approved
ProglumetacinProglumetacin may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
PropacetamolPropacetamol may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
PropicillinThe serum concentration of Sisomicin can be decreased when it is combined with Propicillin.Experimental
PropyphenazonePropyphenazone may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
ProquazoneProquazone may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
ProscillaridinThe serum concentration of Proscillaridin can be decreased when it is combined with Sisomicin.Experimental
PTC299PTC299 may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
PyrantelSisomicin may increase the respiratory depressant activities of Pyrantel.Approved, Vet Approved
RapacuroniumSisomicin may increase the respiratory depressant activities of Rapacuronium.Withdrawn
ResveratrolResveratrol may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental, Investigational
RisedronateSisomicin may increase the hypocalcemic activities of Risedronate.Approved, Investigational
RocuroniumSisomicin may increase the respiratory depressant activities of Rocuronium.Approved
RofecoxibRofecoxib may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational, Withdrawn
SalicylamideSalicylamide may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
Salicylic acidSalicylic acid may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Vet Approved
SalsalateSalsalate may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
SemapimodSemapimod may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
SeratrodastSeratrodast may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
SerrapeptaseSerrapeptase may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
SRT501SRT501 may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
SuccinylcholineSisomicin may increase the respiratory depressant activities of Succinylcholine.Approved
SulbactamThe serum concentration of Sisomicin can be decreased when it is combined with Sulbactam.Approved
SulbenicillinThe serum concentration of Sisomicin can be decreased when it is combined with Sulbenicillin.Experimental
SulfasalazineSulfasalazine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
SulindacSulindac may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
SultamicillinThe serum concentration of Sisomicin can be decreased when it is combined with Sultamicillin.Investigational
SuprofenSuprofen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Withdrawn
SuxibuzoneSuxibuzone may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
TalampicillinThe serum concentration of Sisomicin can be decreased when it is combined with Talampicillin.Experimental
TarenflurbilTarenflurbil may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
TazobactamThe serum concentration of Sisomicin can be decreased when it is combined with Tazobactam.Approved
Technetium Tc-99m etidronateSisomicin may increase the hypocalcemic activities of Technetium Tc-99m etidronate.Approved
Technetium Tc-99m medronateSisomicin may increase the hypocalcemic activities of Technetium Tc-99m medronate.Approved
TenidapTenidap may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
Tenofovir disoproxilThe serum concentration of Sisomicin can be increased when it is combined with Tenofovir disoproxil.Approved, Investigational
TenoxicamTenoxicam may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
TepoxalinTepoxalin may decrease the excretion rate of Sisomicin which could result in a higher serum level.Vet Approved
TeriflunomideTeriflunomide may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
Tiaprofenic acidTiaprofenic acid may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
TicarcillinThe serum concentration of Sisomicin can be decreased when it is combined with Ticarcillin.Approved, Vet Approved
Tiludronic acidSisomicin may increase the hypocalcemic activities of Tiludronic acid.Approved, Vet Approved
TinoridineTinoridine may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
Tolfenamic AcidTolfenamic Acid may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
TolmetinTolmetin may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
TorasemideThe risk or severity of adverse effects can be increased when Torasemide is combined with Sisomicin.Approved
TranilastTranilast may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational
TribenosideTribenoside may decrease the excretion rate of Sisomicin which could result in a higher serum level.Experimental
TriptolideTriptolide may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational
TubocurarineSisomicin may increase the respiratory depressant activities of Tubocurarine.Approved
ValdecoxibValdecoxib may decrease the excretion rate of Sisomicin which could result in a higher serum level.Investigational, Withdrawn
VancomycinVancomycin may increase the nephrotoxic activities of Sisomicin.Approved
VecuroniumSisomicin may increase the respiratory depressant activities of Vecuronium.Approved
ZaltoprofenZaltoprofen may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved
ZileutonZileuton may decrease the excretion rate of Sisomicin which could result in a higher serum level.Approved, Investigational, Withdrawn
Zoledronic acidSisomicin may increase the hypocalcemic activities of Zoledronic acid.Approved
ZomepiracZomepirac may decrease the excretion rate of Sisomicin which could result in a higher serum level.Withdrawn
Food Interactions
Not Available

References

Synthesis Reference
Not Available
General References
Not Available
External Links
KEGG Compound
C00494
ChemSpider
33222
ChEBI
9169
ChEMBL
CHEMBL221886
HET
SIS
ATC Codes
J01GB08 — Sisomicin
AHFS Codes
Not Available
PDB Entries
Not Available
FDA label
Not Available
MSDS
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4WithdrawnTreatmentPyoderma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility15.6 mg/mLALOGPS
logP-2ALOGPS
logP-4.3ChemAxon
logS-1.5ALOGPS
pKa (Strongest Acidic)12.55ChemAxon
pKa (Strongest Basic)9.88ChemAxon
Physiological Charge5ChemAxon
Hydrogen Acceptor Count12ChemAxon
Hydrogen Donor Count8ChemAxon
Polar Surface Area213.72 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity110.32 m3·mol-1ChemAxon
Polarizability46.45 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0002-0000900000-c257d090490406f3043c
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0002-0010900000-e957e2ece6cb00541b9b
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0f79-2960000000-e4019234db0edb127967
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0zmi-9500000000-581186dcec1f1ab9320d
LC-MS/MS Spectrum - LC-ESI-QQ , negativeLC-MS/MSsplash10-0ab9-9100000000-ccd5691ace392b03e90b
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0002-0000900000-060193de09eeb53e3e1a
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0230-0274900000-3f1be89196073a2aef6c
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0ir0-0970000000-e8083a0ffe7791382e2b
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-03di-0920000000-eea6c730484f1d2fcc1d
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0nmi-3900000000-df6cc4b9d9d4d7f88835
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-00di-0591000000-0785a7498e5373b2d8a0
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-03fr-1910000000-e0b1b4029b0e6a0848b9
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-03e9-6900000000-fbac675bcbadc5d332ff
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-001i-9300000000-71a42721119dc4209a6f
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-001i-9100000000-f588e80a7fdccf35f2e1
LC-MS/MS Spectrum - LC-ESI-IT , positiveLC-MS/MSsplash10-00di-0109600000-acd2c9f9fca4c7cfba95

Taxonomy

Description
This compound belongs to the class of chemical entities known as aminocyclitol glycosides. These are organic compounds containing an amicocyclitol moiety glycosidically linked to a carbohydrate moiety. There are two major classes of aminoglycosides containing a 2-streptamine core. They are called 4,5- and 4,6-disubstituted 2-deoxystreptamines.
Kingdom
Chemical entities
Super Class
Organic compounds
Class
Organic oxygen compounds
Sub Class
Organooxygen compounds
Direct Parent
Aminocyclitol glycosides
Alternative Parents
O-glycosyl compounds / Aminocyclitols and derivatives / Cyclohexylamines / Cyclohexanols / Oxanes / Monosaccharides / Tertiary alcohols / 1,2-aminoalcohols / Oxacyclic compounds / Dialkylamines
show 4 more
Substituents
Amino cyclitol glycoside / Glycosyl compound / O-glycosyl compound / Aminocyclitol or derivatives / Cyclohexanol / Cyclohexylamine / Cyclitol or derivatives / Monosaccharide / Oxane / Cyclic alcohol
show 17 more
Molecular Framework
Aliphatic heteromonocyclic compounds
External Descriptors
monosaccharide derivative, aminoglycoside antibiotic, amino cyclitol glycoside, beta-L-arabinoside (CHEBI:9169 )

Drug created on October 20, 2016 17:10 / Updated on September 01, 2017 12:22