Tecarfarin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Tecarfarin
Accession Number
DB12823
Type
Small Molecule
Groups
Investigational
Description

Tecarfarin has been used in trials studying the prevention of Thrombosis and Thromboembolism.

Structure
Thumb
Synonyms
Not Available
External IDs
Ati 5923 / ATI-5923
Categories
UNII
WN1479YT50
CAS number
867257-26-9
Weight
Average: 460.328
Monoisotopic: 460.074542529
Chemical Formula
C21H14F6O5
InChI Key
QFLNTQDOVCLQKW-UHFFFAOYSA-N
InChI
InChI=1S/C21H14F6O5/c1-19(20(22,23)24,21(25,26)27)32-17(29)12-8-6-11(7-9-12)10-14-16(28)13-4-2-3-5-15(13)31-18(14)30/h2-9,28H,10H2,1H3
IUPAC Name
1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yl 4-[(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]benzoate
SMILES
CC(OC(=O)C1=CC=C(CC2=C(O)C3=CC=CC=C3OC2=O)C=C1)(C(F)(F)F)C(F)(F)F

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
DexmethylphenidateThe serum concentration of the active metabolites of Tecarfarin can be increased when Tecarfarin is used in combination with Dexmethylphenidate.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

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Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
54718618
PubChem Substance
347828992
ChemSpider
26467760
ChEMBL
CHEMBL2105664
Wikipedia
Tecarfarin

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1RecruitingBasic SciencePharmacokinetic and Pharmacodynamic Profile of Tecarfarin1
2CompletedTreatmentNonvalvular Atrial Fibrillation1
2, 3Unknown StatusTreatmentAtrial Flutter / Myocardial Infarction / Nonvalvular Atrial Fibrillation / Prophylaxis of cardiomyopathy / Venous Thromboembolic Diseases1
3Not Yet RecruitingTreatmentThromboembolism / Thrombotic events1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0026 mg/mLALOGPS
logP4.71ALOGPS
logP5.26ChemAxon
logS-5.2ALOGPS
pKa (Strongest Acidic)5.13ChemAxon
pKa (Strongest Basic)-6.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area72.83 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity99.73 m3·mol-1ChemAxon
Polarizability37.11 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as 4-hydroxycoumarins. These are coumarins that contain one or more hydroxyl groups attached to C4-position the coumarin skeleton.
Kingdom
Organic compounds
Super Class
Phenylpropanoids and polyketides
Class
Coumarins and derivatives
Sub Class
Hydroxycoumarins
Direct Parent
4-hydroxycoumarins
Alternative Parents
Benzoic acid esters / 1-benzopyrans / Benzoyl derivatives / Pyranones and derivatives / Vinylogous acids / Heteroaromatic compounds / Lactones / Carboxylic acid esters / Oxacyclic compounds / Organooxygen compounds
show 4 more
Substituents
4-hydroxycoumarin / Benzoate ester / Benzopyran / 1-benzopyran / Benzoic acid or derivatives / Benzoyl / Pyranone / Monocyclic benzene moiety / Benzenoid / Pyran
show 16 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 18:31 / Updated on June 04, 2019 07:43