Chlorsulfaquinoxaline

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Chlorsulfaquinoxaline
Accession Number
DB12921
Type
Small Molecule
Groups
Investigational
Description

Chlorsulfaquinoxaline has been used in trials studying the treatment of Lung Cancer and Colorectal Cancer.

Structure
Thumb
Synonyms
  • Chloroquinoxaline sulfonamide
Categories
UNII
O0408QB48D
CAS number
97919-22-7
Weight
Average: 334.78
Monoisotopic: 334.0291245
Chemical Formula
C14H11ClN4O2S
InChI Key
CTSNHMQGVWXIEG-UHFFFAOYSA-N
InChI
InChI=1S/C14H11ClN4O2S/c15-11-2-1-3-12-14(11)17-8-13(18-12)19-22(20,21)10-6-4-9(16)5-7-10/h1-8H,16H2,(H,18,19)
IUPAC Name
4-amino-N-(5-chloroquinoxalin-2-yl)benzene-1-sulfonamide
SMILES
NC1=CC=C(C=C1)S(=O)(=O)NC1=NC2=CC=CC(Cl)=C2N=C1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
2,4-thiazolidinedioneThe therapeutic efficacy of 2,4-thiazolidinedione can be increased when used in combination with Chlorsulfaquinoxaline.
AcarboseThe therapeutic efficacy of Acarbose can be increased when used in combination with Chlorsulfaquinoxaline.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be increased when used in combination with Chlorsulfaquinoxaline.
AICA ribonucleotideThe therapeutic efficacy of AICA ribonucleotide can be increased when used in combination with Chlorsulfaquinoxaline.
AlbiglutideThe therapeutic efficacy of Albiglutide can be increased when used in combination with Chlorsulfaquinoxaline.
AllicinThe therapeutic efficacy of Allicin can be increased when used in combination with Chlorsulfaquinoxaline.
AlogliptinThe therapeutic efficacy of Alogliptin can be increased when used in combination with Chlorsulfaquinoxaline.
AMG-222The therapeutic efficacy of AMG-222 can be increased when used in combination with Chlorsulfaquinoxaline.
Aminobenzoic acidThe therapeutic efficacy of Chlorsulfaquinoxaline can be decreased when used in combination with Aminobenzoic acid.
AnagliptinThe therapeutic efficacy of Anagliptin can be increased when used in combination with Chlorsulfaquinoxaline.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
72462
PubChem Substance
347829067
ChemSpider
65384
BindingDB
97028
ChEMBL
CHEMBL1905073

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentColorectal Cancers1
2CompletedTreatmentLung Cancers1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0166 mg/mLALOGPS
logP2.11ALOGPS
logP2.16ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)6.64ChemAxon
pKa (Strongest Basic)2.12ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area97.97 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity84.1 m3·mol-1ChemAxon
Polarizability31.75 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzenesulfonamides
Direct Parent
Aminobenzenesulfonamides
Alternative Parents
Quinoxalines / Benzenesulfonyl compounds / Aniline and substituted anilines / Pyrazines / Organosulfonamides / Imidolactams / Aryl chlorides / Heteroaromatic compounds / Aminosulfonyl compounds / Azacyclic compounds
show 5 more
Substituents
Aminobenzenesulfonamide / Diazanaphthalene / Quinoxaline / Benzenesulfonyl group / Aniline or substituted anilines / Aryl chloride / Aryl halide / Pyrazine / Organosulfonic acid amide / Imidolactam
show 19 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 19:17 / Updated on September 02, 2019 19:49