ODM-201

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
ODM-201
Accession Number
DB12941
Type
Small Molecule
Groups
Investigational
Description

ODM-201 has been used in trials studying the treatment of Prostate Cancer, Pharmacokinetics, Drug Interaction, Castration-Resistant, and Breast cancer female, among others.

Structure
Thumb
Synonyms
Not Available
Categories
Not Available
UNII
X05U0N2RCO
CAS number
1297538-32-9
Weight
Average: 398.85
Monoisotopic: 398.1258016
Chemical Formula
C19H19ClN6O2
InChI Key
BLIJXOOIHRSQRB-PXYINDEMSA-N
InChI
InChI=1S/C19H19ClN6O2/c1-11(22-19(28)18-8-17(12(2)27)23-24-18)10-26-6-5-16(25-26)13-3-4-14(9-21)15(20)7-13/h3-8,11-12,27H,10H2,1-2H3,(H,22,28)(H,23,24)/t11-,12?/m0/s1
IUPAC Name
N-[(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide
SMILES
C[C@@H](CN1C=CC(=N1)C1=CC=C(C#N)C(Cl)=C1)NC(=O)C1=NNC(=C1)C(C)O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
67171867
PubChem Substance
347829085
ChemSpider
38772320
Wikipedia
Darolutamide

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentMalignant Neoplasm of Female Breast1
1CompletedNot AvailableDrug Drug Interaction (DDI) / Healthy Volunteers / Pharmacokinetics1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedOtherBiological Availability1
1CompletedTreatmentProstatic Neoplasms1
1, 2CompletedTreatmentProstate Cancer1
2CompletedTreatmentProstate Cancer1
2RecruitingOtherMetastatic Castrate-resistant Prostate (CRPC) Cancer1
2RecruitingTreatmentMetastatic Hormone Refractory Prostate Cancer / Prostate Cancer1
2RecruitingTreatmentProstate Cancer1
3Active Not RecruitingTreatmentProstatic Neoplasms1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0727 mg/mLALOGPS
logP3ALOGPS
logP2.45ChemAxon
logS-3.7ALOGPS
pKa (Strongest Acidic)9.81ChemAxon
pKa (Strongest Basic)2.37ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area119.62 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity117.16 m3·mol-1ChemAxon
Polarizability41.8 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as phenylpyrazoles. These are compounds containing a phenylpyrazole skeleton, which consists of a pyrazole bound to a phenyl group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Azoles
Sub Class
Pyrazoles
Direct Parent
Phenylpyrazoles
Alternative Parents
Pyrazole-5-carboxamides / Benzonitriles / 2-heteroaryl carboxamides / Chlorobenzenes / Aryl chlorides / Heteroaromatic compounds / Secondary carboxylic acid amides / Secondary alcohols / Nitriles / Azacyclic compounds
show 4 more
Substituents
Phenylpyrazole / 2-heteroaryl carboxamide / Benzonitrile / Pyrazole-5-carboxamide / Chlorobenzene / Halobenzene / Aryl chloride / Aryl halide / Monocyclic benzene moiety / Benzenoid
show 20 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 19:30 / Updated on June 04, 2019 07:45