NAV

Terizidone

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Terizidone
DrugBank Accession Number
DB12954
Background

Terizidone has been used in trials studying the treatment of Tuberculosis, HIV Infections, Multidrug Resistant Tuberculosis, and Extensively-drug Resistant Tuberculosis.

Type
Small Molecule
Groups
Approved, Investigational
Structure
Similar Structures
Weight
Average: 302.29
Monoisotopic: 302.101504947
Chemical Formula
C14H14N4O4
Synonyms
  • Terizidone
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

ATC Codes
J04AK03 — Terizidone
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Alpha amino acids and derivatives
Alternative Parents
Oxazolidinones / Benzene and substituted derivatives / Isoxazolidines / Shiff bases / Propargyl-type 1,3-dipolar organic compounds / Oxacyclic compounds / Azacyclic compounds / Organopnictogen compounds / Organic oxides / Hydrocarbon derivatives
show 1 more
Substituents
Aldimine / Alpha-amino acid or derivatives / Aromatic heteromonocyclic compound / Azacycle / Benzenoid / Carbonyl group / Hydrocarbon derivative / Imine / Isoxazolidine / Monocyclic benzene moiety
show 12 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
1199LEX5N8
CAS number
25683-71-0
InChI Key
ODKYYBOHSVLGNU-IAGONARPSA-N
InChI
InChI=1S/C14H14N4O4/c19-13-11(7-21-17-13)15-5-9-1-2-10(4-3-9)6-16-12-8-22-18-14(12)20/h1-6,11-12H,7-8H2,(H,17,19)(H,18,20)/b15-5+,16-6+
IUPAC Name
4-[(E)-({4-[(1E)-[(3-oxo-1,2-oxazolidin-4-yl)imino]methyl]phenyl}methylidene)amino]-1,2-oxazolidin-3-one
SMILES
O=C1NOCC1\N=C\C1=CC=C(\C=N\C2CONC2=O)C=C1

References

General References
Not Available
PubChem Compound
65720
PubChem Substance
347829095
ChemSpider
59144
RxNav
57047
ChEBI
135278
ChEMBL
CHEMBL2107553
Wikipedia
Terizidone

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2, 3CompletedTreatmentExtensively Drug Resistant Tuberculosis / Multidrug Resistant Tuberculosis / Tuberculosis (TB)1
Not AvailableCompletedNot AvailableCoronavirus Disease 2019 (COVID‑19) / Human Immunodeficiency Virus (HIV) Infections1
Not AvailableRecruitingNot AvailableTuberculosis (TB)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.252 mg/mLALOGPS
logP0.17ALOGPS
logP-0.34Chemaxon
logS-3.1ALOGPS
pKa (Strongest Acidic)3.54Chemaxon
pKa (Strongest Basic)2.75Chemaxon
Physiological Charge-2Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area101.38 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity76.99 m3·mol-1Chemaxon
Polarizability29.9 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-0ukc-1190000000-d0517baa6d98f4100488
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udi-0019000000-b9ac0657fb942909f043
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-1093000000-1ae03fbdc15646f6b350
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-00l6-0591000000-afff3a4e3737da412d8e
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9570000000-6dac88aac4db128535a1
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-003r-0950000000-dedc5148bb7f29c33abf
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-0900000000-93c257025ac56a909f8e
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-173.2683
predicted
DeepCCS 1.0 (2019)
[M+H]+175.62631
predicted
DeepCCS 1.0 (2019)
[M+Na]+181.71944
predicted
DeepCCS 1.0 (2019)

Drug created at October 21, 2016 01:33 / Updated at February 21, 2021 18:54