Showing BioInteractions for Pexidartinib (DB12978)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

	Interacting Group	Interacting Drugs
	Pexidartinib is a Macrophage colony-stimulating factor 1 receptor inhibitor
1	Macrophage colony-stimulating factor 1 receptor inhibitors	Fostamatinib, Sunitinib
2	Macrophage colony-stimulating factor 1 receptor antagonists	Imatinib
3	Macrophage colony-stimulating factor 1 receptor substrates	Erdafitinib

	Interacting Group	Interacting Drugs
	Pexidartinib is a Mast/stem cell growth factor receptor Kit inhibitor
1	Mast/stem cell growth factor receptor Kit antagonists	Dasatinib, Imatinib, Midostaurin, Nilotinib, Sorafenib
2	Mast/stem cell growth factor receptor Kit inhibitors	Avapritinib, Fostamatinib, Lenvatinib, Midostaurin, Pazopanib, Ponatinib, Regorafenib, Ripretinib, Sunitinib
3	Mast/stem cell growth factor receptor Kit agonists	Ancestim
4	Mast/stem cell growth factor receptor Kit substrates	Erdafitinib

	Interacting Group	Interacting Drugs
	Pexidartinib is a Receptor-type tyrosine-protein kinase FLT3 inhibitor
1	Receptor-type tyrosine-protein kinase FLT3 antagonists	Midostaurin, Sorafenib
2	Receptor-type tyrosine-protein kinase FLT3 inhibitors	Brigatinib, Fedratinib, Fostamatinib, Gilteritinib, Midostaurin, Nintedanib, Ponatinib, Pralsetinib, Sunitinib

	Interacting Group	Interacting Drugs
	Pexidartinib is a Platelet-derived growth factor receptor beta inhibitor
1	Platelet-derived growth factor receptor beta antagonists	Dasatinib, Imatinib, Midostaurin, Sorafenib, Trapidil
2	Platelet-derived growth factor receptor beta inhibitors	Fostamatinib, Midostaurin, Nintedanib, Pazopanib, Pralsetinib, Regorafenib, Ripretinib, Sunitinib
3	Platelet-derived growth factor receptor beta agonists	Foreskin fibroblast (neonatal), Polaprezinc
4	Platelet-derived growth factor receptor beta substrates	Erdafitinib

	Interacting Group	Interacting Drugs
	Pexidartinib is a Cytochrome P450 3A4 substrate
1	Cytochrome P450 3A4 substrates	(R)-warfarin, (S)-Warfarin, 1,2-Benzodiazepine, 3,5-diiodothyropropionic acid, 5-androstenedione, 6-O-benzylguanine, 9-aminocamptothecin, Abemaciclib, Abiraterone, Acalabrutinib, Acenocoumarol, Acetaminophen, Adinazolam, Agmatine, Albendazole, Alclometasone, Aldosterone, Alfentanil, Alfuzosin, Aliskiren, Almotriptan, Alogliptin, Alosetron, Alpelisib, alpha-Tocopherol acetate, Alprazolam, Ambrisentan, Ambroxol, Amcinonide, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Androstenedione, Antipyrine, Apalutamide, Apixaban, Apremilast, Aprepitant, Aranidipine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Asenapine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Avanafil, Avapritinib, Axitinib, Azelastine, Azelnidipine, Azimilide, Azithromycin, Balaglitazone, Baloxavir marboxil, Banoxantrone, Baricitinib, Barnidipine, Beclomethasone dipropionate, Bedaquiline, Belinostat, Bencyclane, Benidipine, Benzphetamine, Bepridil, Betamethasone, Betamethasone phosphate, Bexarotene, Bezafibrate, Bicalutamide, Bictegravir, Bimatoprost, Bioallethrin, Bisoprolol, Blonanserin, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromocriptine, Brotizolam, Budesonide, Bupivacaine, Buprenorphine, Buspirone, Busulfan, Butyrfentanyl, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calanolide A, Calcitriol, Canagliflozin, Cannabidiol, Capmatinib, Capravirine, Carbamazepine, Carboxyamidotriazole, Cariprazine, Caroverine, Carvedilol, Celecoxib, Cenobamate, Ceritinib, Cerivastatin, Cethromycin, Cevimeline, Chenodeoxycholic acid, Chlormadinone, Chloroquine, Chlorpheniramine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Ciglitazone, Cilnidipine, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clobetasol, Clobetasol propionate, Clobetasone, Clofibrate, Clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepic acid, Clotiazepam, Clotrimazole, Clozapine, Cobicistat, Cobimetinib, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Corticosterone, Corticotropin, Cortisone acetate, Crizotinib, Cyclandelate, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Cytarabine, Dabrafenib, Daclatasvir, Dacomitinib, Dapagliflozin, Dapoxetine, Dapsone, Darifenacin, Darodipine, Darolutamide, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delamanid, Delavirdine, Demegestone, Desogestrel, Desonide, Desoxycorticosterone acetate, Desoxycorticosterone pivalate, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Dexchlorpheniramine maleate, Dexlansoprazole, Dexloxiglumide, Dexniguldipine, Dextromethorphan, Dextropropoxyphene, Dexverapamil, Diazepam, Diclofenac, Dienogest, Diethylstilbestrol, Difluocortolone, Difluprednate, Digitoxin, Dihydro-alpha-ergocryptine, Dihydrocodeine, Dihydroergocornine, Dihydroergocristine, Dihydroergocryptine, Dihydroergotamine, Diltiazem, Diphenadione, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Doravirine, Dotarizine, Doxazosin, Doxepin, Doxorubicin, Doxycycline, Dronabinol, Dronedarone, Drospirenone, Duvelisib, Dydrogesterone, Ebastine, Efavirenz, Efonidipine, Elbasvir, Eletriptan, Elexacaftor, Eliglustat, Elvitegravir, Emopamil, Enasidenib, Encorafenib, Enfortumab vedotin, Entrectinib, Enzalutamide, Eperisone, Epinastine, Eplerenone, Equilenin, Equilin, Eravacycline, Erdafitinib, Ergoloid mesylate, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esketamine, Esomeprazole, Estazolam, Esterified estrogens, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinylestradiol, Ethosuximide, Ethyl biscoumacetate, Ethylmorphine, Ethynodiol diacetate, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Etynodiol, Everolimus, Exemestane, Fedratinib, Felbamate, Felodipine, Fendiline, Fenfluramine, Fentanyl, Fesoterodine, Finasteride, Fish oil, Flibanserin, Flucloxacillin, Fludrocortisone, Flumethasone, Flunarizine, Flunisolide, Flunitrazepam, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluoxetine, Fluprednidene, Fluprednisolone, Fluprednisolone acetate, Flurandrenolide, Flurazepam, Fluspirilene, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fosphenytoin, Fostamatinib, Fostemsavir, Fulvestrant, Fusidic acid, Galantamine, Gallopamil, Gefitinib, Gemfibrozil, Gestodene, Gestrinone, Gilteritinib, Glasdegib, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halcinonide, Halofantrine, Haloperidol, Halothane, HE3286, Hydrocodone, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydroxychloroquine, Hydroxyprogesterone, Hydroxyprogesterone caproate, Hydroxyzine, Ibrutinib, Ibuprofen, Icotinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indalpine, Indapamide, Indinavir, Ipecac, Irinotecan, Isavuconazole, Isavuconazonium, Isotretinoin, Isradipine, Istradefylline, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Ketoconazole, Lacidipine, Lacosamide, Lansoprazole, Lapatinib, Laquinimod, Larotrectinib, Lefamulin, Lemborexant, Lenvatinib, Lercanidipine, Letrozole, Levacetylmethadol, Levamlodipine, Levobupivacaine, Levocetirizine, Levomenthol, Levomilnacipran, Levonorgestrel, Lidocaine, Lidoflazine, Linagliptin, Liotrix, Lisuride, Lobeglitazone, Lomerizine, Lomitapide, Lonafarnib, Loperamide, Lopinavir, Loratadine, Lorazepam, Lorcaserin, Lorpiprazole, Losartan, Loteprednol etabonate, Lovastatin, Lumefantrine, Lurasidone, Lurbinectedin, Lynestrenol, Lysergic acid diethylamide, Macimorelin, Macitentan, Manidipine, Maraviroc, Medrogestone, Medroxyprogesterone acetate, Medrysone, Mefloquine, Megestrol acetate, Melengestrol, Meloxicam, Meperidine, Meprednisone, Mestranol, Methadone, Methaqualone, Methotrexate, Methoxyflurane, Methylergometrine, Methylprednisolone, Methylprednisone, Methyltestosterone, Methysergide, Metoclopramide, Metoprolol, Mexazolam, Mexiletine, Mianserin, Mibefradil, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Mirabegron, Mirtazapine, Modafinil, Mometasone, Mometasone furoate, Montelukast, Morphine, Mycophenolate mofetil, Nabiximols, Naftopidil, Naloxegol, Nateglinide, Nebivolol, Nefazodone, Nelfinavir, Neratinib, Netoglitazone, Netupitant, Nevirapine, Nicardipine, Nicotine, Nifedipine, Niguldipine, Nilotinib, Niludipine, Nilvadipine, Nimesulide, Nimodipine, Nintedanib, Nisoldipine, Nitrazepam, Nitrendipine, Nomegestrol, Nomegestrol acetate, Norelgestromin, Norethindrone enanthate, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Nortriptyline, Nylidrin, Odanacatib, Olaparib, Oliceridine, Olopatadine, Omeprazole, Ondansetron, Opium, Orphenadrine, Osilodrostat, Osimertinib, Ospemifene, Otilonium, Oxybutynin, Oxycodone, Oxymorphone, Ozanimod, Paclitaxel, Palbociclib, Paliperidone, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Paroxetine, Pazopanib, Pemigatinib, Penfluridol, Perampanel, Perhexiline, Perospirone, Perphenazine, Phenacetin, Phenprocoumon, Phentermine, Phenytoin, Pimecrolimus, Pimozide, Pinacidil, Pinaverium, Pioglitazone, Piperaquine, Pipotiazine, Pitolisant, Plitidepsin, Polatuzumab vedotin, Pomalidomide, Ponatinib, Posaconazole, Pralsetinib, Pranlukast, Prasugrel, Prazepam, Praziquantel, Prednicarbate, Prednisolone, Prednisolone acetate, Prednisolone phosphate, Prednisone, Prednylidene, Pregnenolone, Prenylamine, Pretomanid, Primaquine, Progesterone, Promazine, Promegestone, Propacetamol, Propafenone, Propiverine, Propranolol, Prucalopride, Quazepam, Quetiapine, Quinacrine, Quingestanol, Quinidine, Quinine, Rabeprazole, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Remdesivir, Repaglinide, Retapamulin, Ribociclib, Rifabutin, Rifalazil, Rifapentine, Rifaximin, Rilpivirine, Rimegepant, Rimexolone, Rimonabant, Riociguat, Ripretinib, Risdiplam, Risperidone, Ritonavir, Rivaroxaban, Rivoglitazone, Rofecoxib, Roflumilast, Rolapitant, Romidepsin, Ropivacaine, Rosiglitazone, Rotigotine, Roxithromycin, Rucaparib, Rufinamide, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Segesterone acetate, Selegiline, Seletracetam, Selexipag, Selinexor, Selpercatinib, Selumetinib, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simeprevir, Simvastatin, Siponimod, Sirolimus, Sitagliptin, SN-38, Solifenacin, Sonidegib, Sorafenib, St. John's Wort, Sufentanil, Sulfadiazine, Sulfamethoxazole, Sulfinpyrazone, Sunitinib, Suvorexant, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasimelteon, Tasosartan, Taurochenodeoxycholic acid, Tazemetostat, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Tenapanor, Teniposide, Tenofovir, Tenofovir alafenamide, Terbinafine, Terfenadine, Terguride, Terodiline, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone propionate, Testosterone undecanoate, Tetracycline, Tetrahydropalmatine, Tetrandrine, Tezacaftor, Theophylline, Thiamylal, Thiotepa, Tiagabine, Tianeptine, Ticagrelor, Tinidazole, Tiotropium, Tipranavir, Tirbanibulin, Tocofersolan, Tocopherol, Tofacitinib, Tolfenamic acid, Tolterodine, Tolvaptan, Toremifene, Trabectedin, Tramadol, Tranilast, Trastuzumab deruxtecan, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Triclabendazole, Trifarotene, Trimebutine, Trimethadione, Trimethoprim, Troleandomycin, Ubrogepant, Udenafil, Ulipristal, Umifenovir, Upadacitinib, Valbenazine, Valdecoxib, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vibegron, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinflunine, Vinorelbine, Vinpocetine, Vismodegib, Vitamin D, Vitamin E, Vorapaxar, Voriconazole, Vortioxetine, Voxelotor, Voxilaprevir, Warfarin, WIN 55212-2, Yohimbine, Zafirlukast, Zaleplon, Zanubrutinib, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone, Zotepine, Zuclopenthixol
2	Cytochrome P450 3A4 inducers	Acetaminophen, Amcinonide, Aminoglutethimide, Amprenavir, Apalutamide, Aprepitant, Aprobarbital, Armodafinil, Artemether, Asunaprevir, Avasimibe, Azatadine, Barbital, Beclomethasone dipropionate, Betamethasone, Betamethasone phosphate, Bexarotene, Bosentan, Budesonide, Calcitriol, Carbamazepine, Cefradine, Cenobamate, Cerivastatin, Chlorphenesin, Chlorpromazine, Clevidipine, Clobazam, Clobetasol, Clobetasol propionate, Clocortolone acetate, Clofibrate, Cloprednol, Clotrimazole, Clozapine, Corticotropin, Cortisone, Cortisone acetate, Cortivazol, Cyclophosphamide, Dabrafenib, Deferasirox, Deflazacort, Delafloxacin, Desonide, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Dicloxacillin, Difluocortolone, Echinacea, Efavirenz, Enasidenib, Enzalutamide, Esketamine, Eslicarbazepine, Eslicarbazepine acetate, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethanol, Etoposide, Etravirine, Felbamate, Flucloxacillin, Flunisolide, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluprednidene, Fluprednidene acetate, Fluticasone, Fluticasone furoate, Formestane, Fosaprepitant, Fosphenytoin, Genistein, Glycerol phenylbutyrate, Griseofulvin, Halometasone, Hydrocortamate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Idelalisib, Ifosfamide, Isavuconazole, Isavuconazonium, Ivermectin, Ivosidenib, Ketamine, Lansoprazole, Lenvatinib, Lesinurad, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Medrysone, Melengestrol acetate, Meperidine, Meprednisone, Metamizole, Methadone, Methylprednisolone, Methylprednisolone hemisuccinate, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Mometasone, Mometasone furoate, Nafcillin, Nevirapine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Paramethasone, Pegvisomant, Pentobarbital, Perampanel, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Pitolisant, Pralsetinib, Prednicarbate, Prednisolone, Prednisolone acetate, Prednisolone hemisuccinate, Prednisolone phosphate, Prednisone, Prednisone acetate, Prednylidene, Primidone, Probenecid, Progesterone, Propacetamol, Quinine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rimexolone, Rofecoxib, Rufinamide, Sarilumab, Seratrodast, Siltuximab, St. John's Wort, Sulfinpyrazone, Tamoxifen, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thiamylal, Tocilizumab, Topiramate, Topotecan, Trametinib, Triamcinolone, Troglitazone, Vemurafenib, Vinblastine, Vitamin E, Warfarin
3	Cytochrome P450 3A4 inhibitors	6-Deoxyerythronolide B, Abametapir, Abemaciclib, Abiraterone, Acalabrutinib, Acetazolamide, Aldesleukin, Amiodarone, Amphotericin B, Amprenavir, Anastrozole, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, AVE9633, Azelastine, Azithromycin, Barnidipine, Benidipine, Berotralstat, Bicalutamide, Bifonazole, Black cohosh, Boceprevir, Bosutinib, Brefeldin A, Brentuximab vedotin, Bromocriptine, Bryostatin 1, Buprenorphine, Cabergoline, Candicidin, Capsaicin, Carbomycin, Caspofungin, Cenobamate, Ceritinib, Cerivastatin, Cethromycin, Chloramphenicol, Chlorzoxazone, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clascoterone, Clevidipine, Clindamycin, Clofazimine, Clotrimazole, Clozapine, Cobicistat, Colchicine, Coltuximab ravtansine, Conivaptan, Crizotinib, Curcumin, Curcumin sulfate, Cyclosporine, Cyproterone acetate, Dalfopristin, Danazol, Danoprevir, Dapoxetine, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Desvenlafaxine, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Dextropropoxyphene, Diazepam, Diclofenac, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Dirithromycin, Ditiocarb, Docetaxel, Doramectin, Dovitinib, Doxorubicin, Doxycycline, Dronedarone, Econazole, Edetate calcium disodium anhydrous, Edetate disodium anhydrous, Efavirenz, Efonidipine, Elbasvir, Elexacaftor, Elvitegravir, Enasidenib, Epinephrine, Epofolate, Epothilone D, Eprinomectin, Ergotamine, Erlotinib, Erythromycin, Ethanol, Etoposide, Etoricoxib, Ezetimibe, Felodipine, Fidaxomicin, Fluconazole, Fluoxetine, Flurithromycin, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fostamatinib, Fusidic acid, Gefitinib, Ginkgo biloba, Glecaprevir, Glyburide, GPI-1485, Haloperidol, Hydralazine, Idelalisib, Ifosfamide, Imatinib, Indalpine, Indinavir, Indisulam, Irbesartan, Isavuconazole, Isavuconazonium, Isradipine, Itraconazole, Ivacaftor, Ixabepilone, Ketazolam, Ketoconazole, Kitasamycin, KOS-1584, Lanreotide, Lansoprazole, Lapatinib, Lenvatinib, Lercanidipine, Lestaurtinib, Letermovir, Levosalbutamol, Linagliptin, Lomustine, Lonafarnib, Loperamide, Lopinavir, Loratadine, Lorvotuzumab mertansine, Losartan, Lovastatin, Luliconazole, Manidipine, Medical Cannabis, Mefloquine, Mepartricin, Mequitazine, Methadone, Methimazole, Methylene blue, Methylergometrine, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Miocamycin, Mirtazapine, Mirvetuximab soravtansine, Mitemcinal, Mitoxantrone, Naloxone, Natamycin, Nefazodone, Nelfinavir, Netupitant, Niacin, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nitric Oxide, Norfloxacin, Noscapine, Octreotide, Olanzapine, Olaparib, Oleandomycin, Omeprazole, Oritavancin, Orphenadrine, Osilodrostat, Osimertinib, Oxcarbazepine, Oxetacaine, Oxybutynin, Oxymetholone, Palbociclib, Paramethasone, Paroxetine, Pasireotide, Patupilone, Pazopanib, Peppermint oil, Pergolide, Phenelzine, Pilocarpine, Pimecrolimus, Pimozide, Piperaquine, Piperine, Posaconazole, Pralsetinib, Primaquine, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Remacemide, Remdesivir, Resveratrol, Ribociclib, Ridaforolimus, Rifamycin, Rilpivirine, Rimegepant, Ritonavir, Rokitamycin, Roxithromycin, Rucaparib, Rutin, Sagopilone, Salbutamol, Saquinavir, Saracatinib, Sarilumab, Selamectin, Seproxetine, Simeprevir, Sitaxentan, SN-38, Solithromycin, Somatostatin, Sorafenib, Stiripentol, Sulfanilamide, Sunitinib, Tamoxifen, Telaprevir, Telithromycin, Teniposide, Terfenadine, Tesmilifene, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetracycline, Ticagrelor, Tildipirosin, Tilmicosin, Tioconazole, Tipranavir, Tirbanibulin, Tofisopam, Topiroxostat, Topotecan, Toremifene, Trastuzumab emtansine, Triclabendazole, Troleandomycin, Tylosin, Tylvalosin, Valproic acid, Vapreotide, Venetoclax, Verapamil, Vinblastine, Voriconazole, WIN 55212-2, Zafirlukast, Zimelidine

	Interacting Group	Interacting Drugs
	Pexidartinib is a Cytochrome P450 3A4 inhibitor
1	Cytochrome P450 3A4 substrates	(R)-warfarin, (S)-Warfarin, 1,2-Benzodiazepine, 3,5-diiodothyropropionic acid, 5-androstenedione, 6-O-benzylguanine, 9-aminocamptothecin, Abemaciclib, Abiraterone, Acalabrutinib, Acenocoumarol, Acetaminophen, Adinazolam, Agmatine, Albendazole, Alclometasone, Aldosterone, Alfentanil, Alfuzosin, Aliskiren, Almotriptan, Alogliptin, Alosetron, Alpelisib, alpha-Tocopherol acetate, Alprazolam, Ambrisentan, Ambroxol, Amcinonide, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Androstenedione, Antipyrine, Apalutamide, Apixaban, Apremilast, Aprepitant, Aranidipine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Asenapine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Avanafil, Avapritinib, Axitinib, Azelastine, Azelnidipine, Azimilide, Azithromycin, Balaglitazone, Baloxavir marboxil, Banoxantrone, Baricitinib, Barnidipine, Beclomethasone dipropionate, Bedaquiline, Belinostat, Bencyclane, Benidipine, Benzphetamine, Bepridil, Betamethasone, Betamethasone phosphate, Bexarotene, Bezafibrate, Bicalutamide, Bictegravir, Bimatoprost, Bioallethrin, Bisoprolol, Blonanserin, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromocriptine, Brotizolam, Budesonide, Bupivacaine, Buprenorphine, Buspirone, Busulfan, Butyrfentanyl, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calanolide A, Calcitriol, Canagliflozin, Cannabidiol, Capmatinib, Capravirine, Carbamazepine, Carboxyamidotriazole, Cariprazine, Caroverine, Carvedilol, Celecoxib, Cenobamate, Ceritinib, Cerivastatin, Cethromycin, Cevimeline, Chenodeoxycholic acid, Chlormadinone, Chloroquine, Chlorpheniramine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Ciglitazone, Cilnidipine, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clobetasol, Clobetasol propionate, Clobetasone, Clofibrate, Clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepic acid, Clotiazepam, Clotrimazole, Clozapine, Cobicistat, Cobimetinib, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Corticosterone, Corticotropin, Cortisone acetate, Crizotinib, Cyclandelate, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Cytarabine, Dabrafenib, Daclatasvir, Dacomitinib, Dapagliflozin, Dapoxetine, Dapsone, Darifenacin, Darodipine, Darolutamide, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delamanid, Delavirdine, Demegestone, Desogestrel, Desonide, Desoxycorticosterone acetate, Desoxycorticosterone pivalate, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Dexchlorpheniramine maleate, Dexlansoprazole, Dexloxiglumide, Dexniguldipine, Dextromethorphan, Dextropropoxyphene, Dexverapamil, Diazepam, Diclofenac, Dienogest, Diethylstilbestrol, Difluocortolone, Difluprednate, Digitoxin, Dihydro-alpha-ergocryptine, Dihydrocodeine, Dihydroergocornine, Dihydroergocristine, Dihydroergocryptine, Dihydroergotamine, Diltiazem, Diphenadione, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Doravirine, Dotarizine, Doxazosin, Doxepin, Doxorubicin, Doxycycline, Dronabinol, Dronedarone, Drospirenone, Duvelisib, Dydrogesterone, Ebastine, Efavirenz, Efonidipine, Elbasvir, Eletriptan, Elexacaftor, Eliglustat, Elvitegravir, Emopamil, Enasidenib, Encorafenib, Enfortumab vedotin, Entrectinib, Enzalutamide, Eperisone, Epinastine, Eplerenone, Equilenin, Equilin, Eravacycline, Erdafitinib, Ergoloid mesylate, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esketamine, Esomeprazole, Estazolam, Esterified estrogens, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinylestradiol, Ethosuximide, Ethyl biscoumacetate, Ethylmorphine, Ethynodiol diacetate, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Etynodiol, Everolimus, Exemestane, Fedratinib, Felbamate, Felodipine, Fendiline, Fenfluramine, Fentanyl, Fesoterodine, Finasteride, Fish oil, Flibanserin, Flucloxacillin, Fludrocortisone, Flumethasone, Flunarizine, Flunisolide, Flunitrazepam, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluoxetine, Fluprednidene, Fluprednisolone, Fluprednisolone acetate, Flurandrenolide, Flurazepam, Fluspirilene, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fosphenytoin, Fostamatinib, Fostemsavir, Fulvestrant, Fusidic acid, Galantamine, Gallopamil, Gefitinib, Gemfibrozil, Gestodene, Gestrinone, Gilteritinib, Glasdegib, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halcinonide, Halofantrine, Haloperidol, Halothane, HE3286, Hydrocodone, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydroxychloroquine, Hydroxyprogesterone, Hydroxyprogesterone caproate, Hydroxyzine, Ibrutinib, Ibuprofen, Icotinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indalpine, Indapamide, Indinavir, Ipecac, Irinotecan, Isavuconazole, Isavuconazonium, Isotretinoin, Isradipine, Istradefylline, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Ketoconazole, Lacidipine, Lacosamide, Lansoprazole, Lapatinib, Laquinimod, Larotrectinib, Lefamulin, Lemborexant, Lenvatinib, Lercanidipine, Letrozole, Levacetylmethadol, Levamlodipine, Levobupivacaine, Levocetirizine, Levomenthol, Levomilnacipran, Levonorgestrel, Lidocaine, Lidoflazine, Linagliptin, Liotrix, Lisuride, Lobeglitazone, Lomerizine, Lomitapide, Lonafarnib, Loperamide, Lopinavir, Loratadine, Lorazepam, Lorcaserin, Lorpiprazole, Losartan, Loteprednol etabonate, Lovastatin, Lumefantrine, Lurasidone, Lurbinectedin, Lynestrenol, Lysergic acid diethylamide, Macimorelin, Macitentan, Manidipine, Maraviroc, Medrogestone, Medroxyprogesterone acetate, Medrysone, Mefloquine, Megestrol acetate, Melengestrol, Meloxicam, Meperidine, Meprednisone, Mestranol, Methadone, Methaqualone, Methotrexate, Methoxyflurane, Methylergometrine, Methylprednisolone, Methylprednisone, Methyltestosterone, Methysergide, Metoclopramide, Metoprolol, Mexazolam, Mexiletine, Mianserin, Mibefradil, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Mirabegron, Mirtazapine, Modafinil, Mometasone, Mometasone furoate, Montelukast, Morphine, Mycophenolate mofetil, Nabiximols, Naftopidil, Naloxegol, Nateglinide, Nebivolol, Nefazodone, Nelfinavir, Neratinib, Netoglitazone, Netupitant, Nevirapine, Nicardipine, Nicotine, Nifedipine, Niguldipine, Nilotinib, Niludipine, Nilvadipine, Nimesulide, Nimodipine, Nintedanib, Nisoldipine, Nitrazepam, Nitrendipine, Nomegestrol, Nomegestrol acetate, Norelgestromin, Norethindrone enanthate, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Nortriptyline, Nylidrin, Odanacatib, Olaparib, Oliceridine, Olopatadine, Omeprazole, Ondansetron, Opium, Orphenadrine, Osilodrostat, Osimertinib, Ospemifene, Otilonium, Oxybutynin, Oxycodone, Oxymorphone, Ozanimod, Paclitaxel, Palbociclib, Paliperidone, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Paroxetine, Pazopanib, Pemigatinib, Penfluridol, Perampanel, Perhexiline, Perospirone, Perphenazine, Phenacetin, Phenprocoumon, Phentermine, Phenytoin, Pimecrolimus, Pimozide, Pinacidil, Pinaverium, Pioglitazone, Piperaquine, Pipotiazine, Pitolisant, Plitidepsin, Polatuzumab vedotin, Pomalidomide, Ponatinib, Posaconazole, Pralsetinib, Pranlukast, Prasugrel, Prazepam, Praziquantel, Prednicarbate, Prednisolone, Prednisolone acetate, Prednisolone phosphate, Prednisone, Prednylidene, Pregnenolone, Prenylamine, Pretomanid, Primaquine, Progesterone, Promazine, Promegestone, Propacetamol, Propafenone, Propiverine, Propranolol, Prucalopride, Quazepam, Quetiapine, Quinacrine, Quingestanol, Quinidine, Quinine, Rabeprazole, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Remdesivir, Repaglinide, Retapamulin, Ribociclib, Rifabutin, Rifalazil, Rifapentine, Rifaximin, Rilpivirine, Rimegepant, Rimexolone, Rimonabant, Riociguat, Ripretinib, Risdiplam, Risperidone, Ritonavir, Rivaroxaban, Rivoglitazone, Rofecoxib, Roflumilast, Rolapitant, Romidepsin, Ropivacaine, Rosiglitazone, Rotigotine, Roxithromycin, Rucaparib, Rufinamide, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Segesterone acetate, Selegiline, Seletracetam, Selexipag, Selinexor, Selpercatinib, Selumetinib, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simeprevir, Simvastatin, Siponimod, Sirolimus, Sitagliptin, SN-38, Solifenacin, Sonidegib, Sorafenib, St. John's Wort, Sufentanil, Sulfadiazine, Sulfamethoxazole, Sulfinpyrazone, Sunitinib, Suvorexant, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasimelteon, Tasosartan, Taurochenodeoxycholic acid, Tazemetostat, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Tenapanor, Teniposide, Tenofovir, Tenofovir alafenamide, Terbinafine, Terfenadine, Terguride, Terodiline, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone propionate, Testosterone undecanoate, Tetracycline, Tetrahydropalmatine, Tetrandrine, Tezacaftor, Theophylline, Thiamylal, Thiotepa, Tiagabine, Tianeptine, Ticagrelor, Tinidazole, Tiotropium, Tipranavir, Tirbanibulin, Tocofersolan, Tocopherol, Tofacitinib, Tolfenamic acid, Tolterodine, Tolvaptan, Toremifene, Trabectedin, Tramadol, Tranilast, Trastuzumab deruxtecan, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Triclabendazole, Trifarotene, Trimebutine, Trimethadione, Trimethoprim, Troleandomycin, Ubrogepant, Udenafil, Ulipristal, Umifenovir, Upadacitinib, Valbenazine, Valdecoxib, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vibegron, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinflunine, Vinorelbine, Vinpocetine, Vismodegib, Vitamin D, Vitamin E, Vorapaxar, Voriconazole, Vortioxetine, Voxelotor, Voxilaprevir, Warfarin, WIN 55212-2, Yohimbine, Zafirlukast, Zaleplon, Zanubrutinib, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone, Zotepine, Zuclopenthixol
2	Cytochrome P450 3A4 inducers	Acetaminophen, Amcinonide, Aminoglutethimide, Amprenavir, Apalutamide, Aprepitant, Aprobarbital, Armodafinil, Artemether, Asunaprevir, Avasimibe, Azatadine, Barbital, Beclomethasone dipropionate, Betamethasone, Betamethasone phosphate, Bexarotene, Bosentan, Budesonide, Calcitriol, Carbamazepine, Cefradine, Cenobamate, Cerivastatin, Chlorphenesin, Chlorpromazine, Clevidipine, Clobazam, Clobetasol, Clobetasol propionate, Clocortolone acetate, Clofibrate, Cloprednol, Clotrimazole, Clozapine, Corticotropin, Cortisone, Cortisone acetate, Cortivazol, Cyclophosphamide, Dabrafenib, Deferasirox, Deflazacort, Delafloxacin, Desonide, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Dicloxacillin, Difluocortolone, Echinacea, Efavirenz, Enasidenib, Enzalutamide, Esketamine, Eslicarbazepine, Eslicarbazepine acetate, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethanol, Etoposide, Etravirine, Felbamate, Flucloxacillin, Flunisolide, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluprednidene, Fluprednidene acetate, Fluticasone, Fluticasone furoate, Formestane, Fosaprepitant, Fosphenytoin, Genistein, Glycerol phenylbutyrate, Griseofulvin, Halometasone, Hydrocortamate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Idelalisib, Ifosfamide, Isavuconazole, Isavuconazonium, Ivermectin, Ivosidenib, Ketamine, Lansoprazole, Lenvatinib, Lesinurad, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Medrysone, Melengestrol acetate, Meperidine, Meprednisone, Metamizole, Methadone, Methylprednisolone, Methylprednisolone hemisuccinate, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Mometasone, Mometasone furoate, Nafcillin, Nevirapine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Paramethasone, Pegvisomant, Pentobarbital, Perampanel, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Pitolisant, Pralsetinib, Prednicarbate, Prednisolone, Prednisolone acetate, Prednisolone hemisuccinate, Prednisolone phosphate, Prednisone, Prednisone acetate, Prednylidene, Primidone, Probenecid, Progesterone, Propacetamol, Quinine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rimexolone, Rofecoxib, Rufinamide, Sarilumab, Seratrodast, Siltuximab, St. John's Wort, Sulfinpyrazone, Tamoxifen, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thiamylal, Tocilizumab, Topiramate, Topotecan, Trametinib, Triamcinolone, Troglitazone, Vemurafenib, Vinblastine, Vitamin E, Warfarin
3	Cytochrome P450 3A4 inhibitors	6-Deoxyerythronolide B, Abametapir, Abemaciclib, Abiraterone, Acalabrutinib, Acetazolamide, Aldesleukin, Amiodarone, Amphotericin B, Amprenavir, Anastrozole, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, AVE9633, Azelastine, Azithromycin, Barnidipine, Benidipine, Berotralstat, Bicalutamide, Bifonazole, Black cohosh, Boceprevir, Bosutinib, Brefeldin A, Brentuximab vedotin, Bromocriptine, Bryostatin 1, Buprenorphine, Cabergoline, Candicidin, Capsaicin, Carbomycin, Caspofungin, Cenobamate, Ceritinib, Cerivastatin, Cethromycin, Chloramphenicol, Chlorzoxazone, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clascoterone, Clevidipine, Clindamycin, Clofazimine, Clotrimazole, Clozapine, Cobicistat, Colchicine, Coltuximab ravtansine, Conivaptan, Crizotinib, Curcumin, Curcumin sulfate, Cyclosporine, Cyproterone acetate, Dalfopristin, Danazol, Danoprevir, Dapoxetine, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Desvenlafaxine, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Dextropropoxyphene, Diazepam, Diclofenac, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Dirithromycin, Ditiocarb, Docetaxel, Doramectin, Dovitinib, Doxorubicin, Doxycycline, Dronedarone, Econazole, Edetate calcium disodium anhydrous, Edetate disodium anhydrous, Efavirenz, Efonidipine, Elbasvir, Elexacaftor, Elvitegravir, Enasidenib, Epinephrine, Epofolate, Epothilone D, Eprinomectin, Ergotamine, Erlotinib, Erythromycin, Ethanol, Etoposide, Etoricoxib, Ezetimibe, Felodipine, Fidaxomicin, Fluconazole, Fluoxetine, Flurithromycin, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fostamatinib, Fusidic acid, Gefitinib, Ginkgo biloba, Glecaprevir, Glyburide, GPI-1485, Haloperidol, Hydralazine, Idelalisib, Ifosfamide, Imatinib, Indalpine, Indinavir, Indisulam, Irbesartan, Isavuconazole, Isavuconazonium, Isradipine, Itraconazole, Ivacaftor, Ixabepilone, Ketazolam, Ketoconazole, Kitasamycin, KOS-1584, Lanreotide, Lansoprazole, Lapatinib, Lenvatinib, Lercanidipine, Lestaurtinib, Letermovir, Levosalbutamol, Linagliptin, Lomustine, Lonafarnib, Loperamide, Lopinavir, Loratadine, Lorvotuzumab mertansine, Losartan, Lovastatin, Luliconazole, Manidipine, Medical Cannabis, Mefloquine, Mepartricin, Mequitazine, Methadone, Methimazole, Methylene blue, Methylergometrine, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Miocamycin, Mirtazapine, Mirvetuximab soravtansine, Mitemcinal, Mitoxantrone, Naloxone, Natamycin, Nefazodone, Nelfinavir, Netupitant, Niacin, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nitric Oxide, Norfloxacin, Noscapine, Octreotide, Olanzapine, Olaparib, Oleandomycin, Omeprazole, Oritavancin, Orphenadrine, Osilodrostat, Osimertinib, Oxcarbazepine, Oxetacaine, Oxybutynin, Oxymetholone, Palbociclib, Paramethasone, Paroxetine, Pasireotide, Patupilone, Pazopanib, Peppermint oil, Pergolide, Phenelzine, Pilocarpine, Pimecrolimus, Pimozide, Piperaquine, Piperine, Posaconazole, Pralsetinib, Primaquine, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Remacemide, Remdesivir, Resveratrol, Ribociclib, Ridaforolimus, Rifamycin, Rilpivirine, Rimegepant, Ritonavir, Rokitamycin, Roxithromycin, Rucaparib, Rutin, Sagopilone, Salbutamol, Saquinavir, Saracatinib, Sarilumab, Selamectin, Seproxetine, Simeprevir, Sitaxentan, SN-38, Solithromycin, Somatostatin, Sorafenib, Stiripentol, Sulfanilamide, Sunitinib, Tamoxifen, Telaprevir, Telithromycin, Teniposide, Terfenadine, Tesmilifene, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetracycline, Ticagrelor, Tildipirosin, Tilmicosin, Tioconazole, Tipranavir, Tirbanibulin, Tofisopam, Topiroxostat, Topotecan, Toremifene, Trastuzumab emtansine, Triclabendazole, Troleandomycin, Tylosin, Tylvalosin, Valproic acid, Vapreotide, Venetoclax, Verapamil, Vinblastine, Voriconazole, WIN 55212-2, Zafirlukast, Zimelidine

	Interacting Group	Interacting Drugs
	Pexidartinib is a Cytochrome P450 3A4 inducer
1	Cytochrome P450 3A4 substrates	(R)-warfarin, (S)-Warfarin, 1,2-Benzodiazepine, 3,5-diiodothyropropionic acid, 5-androstenedione, 6-O-benzylguanine, 9-aminocamptothecin, Abemaciclib, Abiraterone, Acalabrutinib, Acenocoumarol, Acetaminophen, Adinazolam, Agmatine, Albendazole, Alclometasone, Aldosterone, Alfentanil, Alfuzosin, Aliskiren, Almotriptan, Alogliptin, Alosetron, Alpelisib, alpha-Tocopherol acetate, Alprazolam, Ambrisentan, Ambroxol, Amcinonide, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Androstenedione, Antipyrine, Apalutamide, Apixaban, Apremilast, Aprepitant, Aranidipine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Asenapine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Avanafil, Avapritinib, Axitinib, Azelastine, Azelnidipine, Azimilide, Azithromycin, Balaglitazone, Baloxavir marboxil, Banoxantrone, Baricitinib, Barnidipine, Beclomethasone dipropionate, Bedaquiline, Belinostat, Bencyclane, Benidipine, Benzphetamine, Bepridil, Betamethasone, Betamethasone phosphate, Bexarotene, Bezafibrate, Bicalutamide, Bictegravir, Bimatoprost, Bioallethrin, Bisoprolol, Blonanserin, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromocriptine, Brotizolam, Budesonide, Bupivacaine, Buprenorphine, Buspirone, Busulfan, Butyrfentanyl, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calanolide A, Calcitriol, Canagliflozin, Cannabidiol, Capmatinib, Capravirine, Carbamazepine, Carboxyamidotriazole, Cariprazine, Caroverine, Carvedilol, Celecoxib, Cenobamate, Ceritinib, Cerivastatin, Cethromycin, Cevimeline, Chenodeoxycholic acid, Chlormadinone, Chloroquine, Chlorpheniramine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Ciglitazone, Cilnidipine, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clobetasol, Clobetasol propionate, Clobetasone, Clofibrate, Clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepic acid, Clotiazepam, Clotrimazole, Clozapine, Cobicistat, Cobimetinib, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Corticosterone, Corticotropin, Cortisone acetate, Crizotinib, Cyclandelate, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Cytarabine, Dabrafenib, Daclatasvir, Dacomitinib, Dapagliflozin, Dapoxetine, Dapsone, Darifenacin, Darodipine, Darolutamide, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delamanid, Delavirdine, Demegestone, Desogestrel, Desonide, Desoxycorticosterone acetate, Desoxycorticosterone pivalate, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Dexchlorpheniramine maleate, Dexlansoprazole, Dexloxiglumide, Dexniguldipine, Dextromethorphan, Dextropropoxyphene, Dexverapamil, Diazepam, Diclofenac, Dienogest, Diethylstilbestrol, Difluocortolone, Difluprednate, Digitoxin, Dihydro-alpha-ergocryptine, Dihydrocodeine, Dihydroergocornine, Dihydroergocristine, Dihydroergocryptine, Dihydroergotamine, Diltiazem, Diphenadione, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Doravirine, Dotarizine, Doxazosin, Doxepin, Doxorubicin, Doxycycline, Dronabinol, Dronedarone, Drospirenone, Duvelisib, Dydrogesterone, Ebastine, Efavirenz, Efonidipine, Elbasvir, Eletriptan, Elexacaftor, Eliglustat, Elvitegravir, Emopamil, Enasidenib, Encorafenib, Enfortumab vedotin, Entrectinib, Enzalutamide, Eperisone, Epinastine, Eplerenone, Equilenin, Equilin, Eravacycline, Erdafitinib, Ergoloid mesylate, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esketamine, Esomeprazole, Estazolam, Esterified estrogens, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinylestradiol, Ethosuximide, Ethyl biscoumacetate, Ethylmorphine, Ethynodiol diacetate, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Etynodiol, Everolimus, Exemestane, Fedratinib, Felbamate, Felodipine, Fendiline, Fenfluramine, Fentanyl, Fesoterodine, Finasteride, Fish oil, Flibanserin, Flucloxacillin, Fludrocortisone, Flumethasone, Flunarizine, Flunisolide, Flunitrazepam, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluoxetine, Fluprednidene, Fluprednisolone, Fluprednisolone acetate, Flurandrenolide, Flurazepam, Fluspirilene, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fosphenytoin, Fostamatinib, Fostemsavir, Fulvestrant, Fusidic acid, Galantamine, Gallopamil, Gefitinib, Gemfibrozil, Gestodene, Gestrinone, Gilteritinib, Glasdegib, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halcinonide, Halofantrine, Haloperidol, Halothane, HE3286, Hydrocodone, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydroxychloroquine, Hydroxyprogesterone, Hydroxyprogesterone caproate, Hydroxyzine, Ibrutinib, Ibuprofen, Icotinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indalpine, Indapamide, Indinavir, Ipecac, Irinotecan, Isavuconazole, Isavuconazonium, Isotretinoin, Isradipine, Istradefylline, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Ketoconazole, Lacidipine, Lacosamide, Lansoprazole, Lapatinib, Laquinimod, Larotrectinib, Lefamulin, Lemborexant, Lenvatinib, Lercanidipine, Letrozole, Levacetylmethadol, Levamlodipine, Levobupivacaine, Levocetirizine, Levomenthol, Levomilnacipran, Levonorgestrel, Lidocaine, Lidoflazine, Linagliptin, Liotrix, Lisuride, Lobeglitazone, Lomerizine, Lomitapide, Lonafarnib, Loperamide, Lopinavir, Loratadine, Lorazepam, Lorcaserin, Lorpiprazole, Losartan, Loteprednol etabonate, Lovastatin, Lumefantrine, Lurasidone, Lurbinectedin, Lynestrenol, Lysergic acid diethylamide, Macimorelin, Macitentan, Manidipine, Maraviroc, Medrogestone, Medroxyprogesterone acetate, Medrysone, Mefloquine, Megestrol acetate, Melengestrol, Meloxicam, Meperidine, Meprednisone, Mestranol, Methadone, Methaqualone, Methotrexate, Methoxyflurane, Methylergometrine, Methylprednisolone, Methylprednisone, Methyltestosterone, Methysergide, Metoclopramide, Metoprolol, Mexazolam, Mexiletine, Mianserin, Mibefradil, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Mirabegron, Mirtazapine, Modafinil, Mometasone, Mometasone furoate, Montelukast, Morphine, Mycophenolate mofetil, Nabiximols, Naftopidil, Naloxegol, Nateglinide, Nebivolol, Nefazodone, Nelfinavir, Neratinib, Netoglitazone, Netupitant, Nevirapine, Nicardipine, Nicotine, Nifedipine, Niguldipine, Nilotinib, Niludipine, Nilvadipine, Nimesulide, Nimodipine, Nintedanib, Nisoldipine, Nitrazepam, Nitrendipine, Nomegestrol, Nomegestrol acetate, Norelgestromin, Norethindrone enanthate, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Nortriptyline, Nylidrin, Odanacatib, Olaparib, Oliceridine, Olopatadine, Omeprazole, Ondansetron, Opium, Orphenadrine, Osilodrostat, Osimertinib, Ospemifene, Otilonium, Oxybutynin, Oxycodone, Oxymorphone, Ozanimod, Paclitaxel, Palbociclib, Paliperidone, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Paroxetine, Pazopanib, Pemigatinib, Penfluridol, Perampanel, Perhexiline, Perospirone, Perphenazine, Phenacetin, Phenprocoumon, Phentermine, Phenytoin, Pimecrolimus, Pimozide, Pinacidil, Pinaverium, Pioglitazone, Piperaquine, Pipotiazine, Pitolisant, Plitidepsin, Polatuzumab vedotin, Pomalidomide, Ponatinib, Posaconazole, Pralsetinib, Pranlukast, Prasugrel, Prazepam, Praziquantel, Prednicarbate, Prednisolone, Prednisolone acetate, Prednisolone phosphate, Prednisone, Prednylidene, Pregnenolone, Prenylamine, Pretomanid, Primaquine, Progesterone, Promazine, Promegestone, Propacetamol, Propafenone, Propiverine, Propranolol, Prucalopride, Quazepam, Quetiapine, Quinacrine, Quingestanol, Quinidine, Quinine, Rabeprazole, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Remdesivir, Repaglinide, Retapamulin, Ribociclib, Rifabutin, Rifalazil, Rifapentine, Rifaximin, Rilpivirine, Rimegepant, Rimexolone, Rimonabant, Riociguat, Ripretinib, Risdiplam, Risperidone, Ritonavir, Rivaroxaban, Rivoglitazone, Rofecoxib, Roflumilast, Rolapitant, Romidepsin, Ropivacaine, Rosiglitazone, Rotigotine, Roxithromycin, Rucaparib, Rufinamide, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Segesterone acetate, Selegiline, Seletracetam, Selexipag, Selinexor, Selpercatinib, Selumetinib, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simeprevir, Simvastatin, Siponimod, Sirolimus, Sitagliptin, SN-38, Solifenacin, Sonidegib, Sorafenib, St. John's Wort, Sufentanil, Sulfadiazine, Sulfamethoxazole, Sulfinpyrazone, Sunitinib, Suvorexant, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasimelteon, Tasosartan, Taurochenodeoxycholic acid, Tazemetostat, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Tenapanor, Teniposide, Tenofovir, Tenofovir alafenamide, Terbinafine, Terfenadine, Terguride, Terodiline, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone propionate, Testosterone undecanoate, Tetracycline, Tetrahydropalmatine, Tetrandrine, Tezacaftor, Theophylline, Thiamylal, Thiotepa, Tiagabine, Tianeptine, Ticagrelor, Tinidazole, Tiotropium, Tipranavir, Tirbanibulin, Tocofersolan, Tocopherol, Tofacitinib, Tolfenamic acid, Tolterodine, Tolvaptan, Toremifene, Trabectedin, Tramadol, Tranilast, Trastuzumab deruxtecan, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Triclabendazole, Trifarotene, Trimebutine, Trimethadione, Trimethoprim, Troleandomycin, Ubrogepant, Udenafil, Ulipristal, Umifenovir, Upadacitinib, Valbenazine, Valdecoxib, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vibegron, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinflunine, Vinorelbine, Vinpocetine, Vismodegib, Vitamin D, Vitamin E, Vorapaxar, Voriconazole, Vortioxetine, Voxelotor, Voxilaprevir, Warfarin, WIN 55212-2, Yohimbine, Zafirlukast, Zaleplon, Zanubrutinib, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone, Zotepine, Zuclopenthixol
2	Cytochrome P450 3A4 inducers	Acetaminophen, Amcinonide, Aminoglutethimide, Amprenavir, Apalutamide, Aprepitant, Aprobarbital, Armodafinil, Artemether, Asunaprevir, Avasimibe, Azatadine, Barbital, Beclomethasone dipropionate, Betamethasone, Betamethasone phosphate, Bexarotene, Bosentan, Budesonide, Calcitriol, Carbamazepine, Cefradine, Cenobamate, Cerivastatin, Chlorphenesin, Chlorpromazine, Clevidipine, Clobazam, Clobetasol, Clobetasol propionate, Clocortolone acetate, Clofibrate, Cloprednol, Clotrimazole, Clozapine, Corticotropin, Cortisone, Cortisone acetate, Cortivazol, Cyclophosphamide, Dabrafenib, Deferasirox, Deflazacort, Delafloxacin, Desonide, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Dicloxacillin, Difluocortolone, Echinacea, Efavirenz, Enasidenib, Enzalutamide, Esketamine, Eslicarbazepine, Eslicarbazepine acetate, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethanol, Etoposide, Etravirine, Felbamate, Flucloxacillin, Flunisolide, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluprednidene, Fluprednidene acetate, Fluticasone, Fluticasone furoate, Formestane, Fosaprepitant, Fosphenytoin, Genistein, Glycerol phenylbutyrate, Griseofulvin, Halometasone, Hydrocortamate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Idelalisib, Ifosfamide, Isavuconazole, Isavuconazonium, Ivermectin, Ivosidenib, Ketamine, Lansoprazole, Lenvatinib, Lesinurad, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Medrysone, Melengestrol acetate, Meperidine, Meprednisone, Metamizole, Methadone, Methylprednisolone, Methylprednisolone hemisuccinate, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Mometasone, Mometasone furoate, Nafcillin, Nevirapine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Paramethasone, Pegvisomant, Pentobarbital, Perampanel, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Pitolisant, Pralsetinib, Prednicarbate, Prednisolone, Prednisolone acetate, Prednisolone hemisuccinate, Prednisolone phosphate, Prednisone, Prednisone acetate, Prednylidene, Primidone, Probenecid, Progesterone, Propacetamol, Quinine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rimexolone, Rofecoxib, Rufinamide, Sarilumab, Seratrodast, Siltuximab, St. John's Wort, Sulfinpyrazone, Tamoxifen, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thiamylal, Tocilizumab, Topiramate, Topotecan, Trametinib, Triamcinolone, Troglitazone, Vemurafenib, Vinblastine, Vitamin E, Warfarin
3	Cytochrome P450 3A4 inhibitors	6-Deoxyerythronolide B, Abametapir, Abemaciclib, Abiraterone, Acalabrutinib, Acetazolamide, Aldesleukin, Amiodarone, Amphotericin B, Amprenavir, Anastrozole, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, AVE9633, Azelastine, Azithromycin, Barnidipine, Benidipine, Berotralstat, Bicalutamide, Bifonazole, Black cohosh, Boceprevir, Bosutinib, Brefeldin A, Brentuximab vedotin, Bromocriptine, Bryostatin 1, Buprenorphine, Cabergoline, Candicidin, Capsaicin, Carbomycin, Caspofungin, Cenobamate, Ceritinib, Cerivastatin, Cethromycin, Chloramphenicol, Chlorzoxazone, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clascoterone, Clevidipine, Clindamycin, Clofazimine, Clotrimazole, Clozapine, Cobicistat, Colchicine, Coltuximab ravtansine, Conivaptan, Crizotinib, Curcumin, Curcumin sulfate, Cyclosporine, Cyproterone acetate, Dalfopristin, Danazol, Danoprevir, Dapoxetine, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Desvenlafaxine, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Dextropropoxyphene, Diazepam, Diclofenac, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Dirithromycin, Ditiocarb, Docetaxel, Doramectin, Dovitinib, Doxorubicin, Doxycycline, Dronedarone, Econazole, Edetate calcium disodium anhydrous, Edetate disodium anhydrous, Efavirenz, Efonidipine, Elbasvir, Elexacaftor, Elvitegravir, Enasidenib, Epinephrine, Epofolate, Epothilone D, Eprinomectin, Ergotamine, Erlotinib, Erythromycin, Ethanol, Etoposide, Etoricoxib, Ezetimibe, Felodipine, Fidaxomicin, Fluconazole, Fluoxetine, Flurithromycin, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fostamatinib, Fusidic acid, Gefitinib, Ginkgo biloba, Glecaprevir, Glyburide, GPI-1485, Haloperidol, Hydralazine, Idelalisib, Ifosfamide, Imatinib, Indalpine, Indinavir, Indisulam, Irbesartan, Isavuconazole, Isavuconazonium, Isradipine, Itraconazole, Ivacaftor, Ixabepilone, Ketazolam, Ketoconazole, Kitasamycin, KOS-1584, Lanreotide, Lansoprazole, Lapatinib, Lenvatinib, Lercanidipine, Lestaurtinib, Letermovir, Levosalbutamol, Linagliptin, Lomustine, Lonafarnib, Loperamide, Lopinavir, Loratadine, Lorvotuzumab mertansine, Losartan, Lovastatin, Luliconazole, Manidipine, Medical Cannabis, Mefloquine, Mepartricin, Mequitazine, Methadone, Methimazole, Methylene blue, Methylergometrine, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Miocamycin, Mirtazapine, Mirvetuximab soravtansine, Mitemcinal, Mitoxantrone, Naloxone, Natamycin, Nefazodone, Nelfinavir, Netupitant, Niacin, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nitric Oxide, Norfloxacin, Noscapine, Octreotide, Olanzapine, Olaparib, Oleandomycin, Omeprazole, Oritavancin, Orphenadrine, Osilodrostat, Osimertinib, Oxcarbazepine, Oxetacaine, Oxybutynin, Oxymetholone, Palbociclib, Paramethasone, Paroxetine, Pasireotide, Patupilone, Pazopanib, Peppermint oil, Pergolide, Phenelzine, Pilocarpine, Pimecrolimus, Pimozide, Piperaquine, Piperine, Posaconazole, Pralsetinib, Primaquine, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Remacemide, Remdesivir, Resveratrol, Ribociclib, Ridaforolimus, Rifamycin, Rilpivirine, Rimegepant, Ritonavir, Rokitamycin, Roxithromycin, Rucaparib, Rutin, Sagopilone, Salbutamol, Saquinavir, Saracatinib, Sarilumab, Selamectin, Seproxetine, Simeprevir, Sitaxentan, SN-38, Solithromycin, Somatostatin, Sorafenib, Stiripentol, Sulfanilamide, Sunitinib, Tamoxifen, Telaprevir, Telithromycin, Teniposide, Terfenadine, Tesmilifene, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetracycline, Ticagrelor, Tildipirosin, Tilmicosin, Tioconazole, Tipranavir, Tirbanibulin, Tofisopam, Topiroxostat, Topotecan, Toremifene, Trastuzumab emtansine, Triclabendazole, Troleandomycin, Tylosin, Tylvalosin, Valproic acid, Vapreotide, Venetoclax, Verapamil, Vinblastine, Voriconazole, WIN 55212-2, Zafirlukast, Zimelidine

	Interacting Group	Interacting Drugs
	Pexidartinib is a UDP-glucuronosyltransferase 1-4 substrate
1	UDP-glucuronosyltransferase 1-4 substrates	Amitriptyline, Anastrozole, Asenapine, Clozapine, Cyclobenzaprine, Enasidenib, Ethinylestradiol, Ezogabine, Idelalisib, Imidafenacin, Midazolam, Olanzapine, Osilodrostat, Paricalcitol, Phenytoin, Tecovirimat, Trifluoperazine, Troglitazone, Valproic acid
2	UDP-glucuronosyltransferase 1-4 inhibitors	Ertugliflozin, Idelalisib, Methylene blue

	Interacting Group	Interacting Drugs
	Pexidartinib is a Cytochrome P450 2B6 inhibitor
1	Cytochrome P450 2B6 substrates	Amitriptyline, Amlodipine, Antipyrine, Apomorphine, Artemether, Artemisinin, Asunaprevir, Banoxantrone, Benzphetamine, Brivaracetam, Bupropion, Carbamazepine, Cenobamate, Cinnarizine, Cisapride, Clobazam, Clomethiazole, Clopidogrel, Clotiazepam, Cyclophosphamide, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Domperidone, Efavirenz, Enasidenib, Epinastine, Esketamine, Estrone, Ethylmorphine, Fenfluramine, Flunitrazepam, Fluoxetine, Halothane, Hydrocodone, Ifosfamide, Imipramine, Irinotecan, Isoflurane, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Lidocaine, Loperamide, Loratadine, Lorcaserin, Malathion, Meperidine, Mephenytoin, Methadone, Methoxyflurane, Methylphenobarbital, Methyltestosterone, Mexiletine, Mianserin, Nevirapine, Nicotine, Norgestimate, Osilodrostat, Ospemifene, Perampanel, Perhexiline, Permethrin, Phenytoin, Prasugrel, Promethazine, Propofol, Romidepsin, Ropivacaine, Selegiline, Seratrodast, Sertraline, Sevoflurane, Tamoxifen, Temazepam, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tramadol, Tretinoin, Trifarotene, Valproic acid, Velpatasvir, Verapamil, Vortioxetine, Voxelotor
2	Cytochrome P450 2B6 inducers	Armodafinil, Artemether, Artemisinin, Atorvastatin, Betamethasone, Budesonide, Carbamazepine, Cenobamate, Cerivastatin, Clotrimazole, Cyclophosphamide, Dabrafenib, Dexamethasone, Dexamethasone acetate, Efavirenz, Enasidenib, Esketamine, Fluvastatin, Fosphenytoin, Hydrocortisone, Idelalisib, Isavuconazole, Isoflurane, Ivosidenib, Lemborexant, Letermovir, Lorlatinib, Lumacaftor, Metamizole, Methadone, Methylprednisolone, Midostaurin, Modafinil, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Olaparib, Perampanel, Permethrin, Phenobarbital, Phenytoin, Pitolisant, Prednisolone phosphate, Prednisone, Relugolix, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Simvastatin, Sulfinpyrazone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Troglitazone, Vemurafenib, Zanubrutinib
3	Cytochrome P450 2B6 inhibitors	Abametapir, Abemaciclib, Amlodipine, Amprenavir, Azelastine, Cenobamate, Cisplatin, Clascoterone, Clopidogrel, Clotrimazole, Colchicine, Crisaborole, Crizotinib, Curcumin, Curcumin sulfate, Desipramine, Doxorubicin, Elexacaftor, Enasidenib, Enzalutamide, Ethanol, Fluvoxamine, Isoflurane, Itraconazole, Ketoconazole, Lenvatinib, Lopinavir, Manidipine, Memantine, Methimazole, Methylene blue, Miconazole, Modafinil, Nelfinavir, Nitric Oxide, Orphenadrine, Paroxetine, Phencyclidine, Piperaquine, Quazepam, Quinidine, Raloxifene, Regorafenib, Rifamycin, Rilpivirine, Ritonavir, Roxithromycin, Safinamide, Selegiline, Sertraline, Simvastatin, Sorafenib, Sulfaphenazole, Tamoxifen, Thiotepa, Ticlopidine, Tirbanibulin, Triclabendazole, Voriconazole
4	Cytochrome P450 2B6 activators	Verapamil

	Interacting Group	Interacting Drugs
	Pexidartinib is a Cytochrome P450 2B6 inducer
1	Cytochrome P450 2B6 substrates	Amitriptyline, Amlodipine, Antipyrine, Apomorphine, Artemether, Artemisinin, Asunaprevir, Banoxantrone, Benzphetamine, Brivaracetam, Bupropion, Carbamazepine, Cenobamate, Cinnarizine, Cisapride, Clobazam, Clomethiazole, Clopidogrel, Clotiazepam, Cyclophosphamide, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Domperidone, Efavirenz, Enasidenib, Epinastine, Esketamine, Estrone, Ethylmorphine, Fenfluramine, Flunitrazepam, Fluoxetine, Halothane, Hydrocodone, Ifosfamide, Imipramine, Irinotecan, Isoflurane, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Lidocaine, Loperamide, Loratadine, Lorcaserin, Malathion, Meperidine, Mephenytoin, Methadone, Methoxyflurane, Methylphenobarbital, Methyltestosterone, Mexiletine, Mianserin, Nevirapine, Nicotine, Norgestimate, Osilodrostat, Ospemifene, Perampanel, Perhexiline, Permethrin, Phenytoin, Prasugrel, Promethazine, Propofol, Romidepsin, Ropivacaine, Selegiline, Seratrodast, Sertraline, Sevoflurane, Tamoxifen, Temazepam, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tramadol, Tretinoin, Trifarotene, Valproic acid, Velpatasvir, Verapamil, Vortioxetine, Voxelotor
2	Cytochrome P450 2B6 inducers	Armodafinil, Artemether, Artemisinin, Atorvastatin, Betamethasone, Budesonide, Carbamazepine, Cenobamate, Cerivastatin, Clotrimazole, Cyclophosphamide, Dabrafenib, Dexamethasone, Dexamethasone acetate, Efavirenz, Enasidenib, Esketamine, Fluvastatin, Fosphenytoin, Hydrocortisone, Idelalisib, Isavuconazole, Isoflurane, Ivosidenib, Lemborexant, Letermovir, Lorlatinib, Lumacaftor, Metamizole, Methadone, Methylprednisolone, Midostaurin, Modafinil, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Olaparib, Perampanel, Permethrin, Phenobarbital, Phenytoin, Pitolisant, Prednisolone phosphate, Prednisone, Relugolix, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Simvastatin, Sulfinpyrazone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Troglitazone, Vemurafenib, Zanubrutinib
3	Cytochrome P450 2B6 inhibitors	Abametapir, Abemaciclib, Amlodipine, Amprenavir, Azelastine, Cenobamate, Cisplatin, Clascoterone, Clopidogrel, Clotrimazole, Colchicine, Crisaborole, Crizotinib, Curcumin, Curcumin sulfate, Desipramine, Doxorubicin, Elexacaftor, Enasidenib, Enzalutamide, Ethanol, Fluvoxamine, Isoflurane, Itraconazole, Ketoconazole, Lenvatinib, Lopinavir, Manidipine, Memantine, Methimazole, Methylene blue, Miconazole, Modafinil, Nelfinavir, Nitric Oxide, Orphenadrine, Paroxetine, Phencyclidine, Piperaquine, Quazepam, Quinidine, Raloxifene, Regorafenib, Rifamycin, Rilpivirine, Ritonavir, Roxithromycin, Safinamide, Selegiline, Sertraline, Simvastatin, Sorafenib, Sulfaphenazole, Tamoxifen, Thiotepa, Ticlopidine, Tirbanibulin, Triclabendazole, Voriconazole
4	Cytochrome P450 2B6 activators	Verapamil

	Interacting Group	Interacting Drugs
	Pexidartinib is a Cytochrome P450 2C9 inhibitor
1	Cytochrome P450 2C9 inhibitors	Abemaciclib, Abiraterone, Acetyl sulfisoxazole, Agomelatine, Amiodarone, Amodiaquine, Anastrozole, Aprepitant, Armodafinil, Atazanavir, Atorvastatin, Atovaquone, Avasimibe, Azelastine, Belinostat, Benzbromarone, Bicalutamide, Black cohosh, Bortezomib, Candesartan, Capecitabine, Ceritinib, Cerivastatin, Cimetidine, Cisapride, Cisplatin, Clascoterone, Clevidipine, Clinafloxacin, Clopidogrel, Clotrimazole, Crisaborole, Curcumin, Curcumin sulfate, Cyclizine, Delavirdine, Dexloxiglumide, Diacerein, Diethylstilbestrol, Doconexent, Dosulepin, Efavirenz, Elexacaftor, Enasidenib, Epinephrine, Estrone sulfate, Ethanol, Etoricoxib, Etravirine, Felbamate, Felodipine, Fenofibrate, Flecainide, Floxuridine, Fluconazole, Fluorouracil, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Genistein, Ginkgo biloba, Glyburide, Imatinib, Iproniazid, Isavuconazole, Isoniazid, Ketoconazole, Ketoprofen, Lansoprazole, Leflunomide, Lenvatinib, Levofloxacin, Lifitegrast, Lobeglitazone, Lopinavir, Lumacaftor, Manidipine, Medical Cannabis, Medroxyprogesterone acetate, Methimazole, Methylene blue, Metronidazole, Miconazole, Midostaurin, Mifepristone, Modafinil, Nabilone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Noscapine, Olanzapine, Oritavancin, Oxandrolone, Paroxetine, Phenylbutazone, Phenytoin, Pralsetinib, Pranlukast, Probenecid, Progesterone, Promethazine, Quinidine, Rabeprazole, Regorafenib, Rhein, Rifamycin, Rucaparib, Safinamide, Seproxetine, Sertraline, Sildenafil, Simvastatin, Sitaxentan, Sorafenib, Stiripentol, Sulconazole, Sulfadiazine, Sulfadimethoxine, Sulfamethizole, Sulfamethoxazole, Sulfamoxole, Sulfaphenazole, Sulfapyridine, Sulfinpyrazone, Sulfisoxazole, Suprofen, Tamoxifen, Teniposide, Ticagrelor, Ticlopidine, Tienilic acid, Tirbanibulin, Tolcapone, Topiroxostat, Torasemide, Tranylcypromine, Troglitazone, Ubrogepant, Valdecoxib, Valproic acid, Vemurafenib, Verapamil, Vismodegib, Voriconazole, Zafirlukast, Zucapsaicin
2	Cytochrome P450 2C9 substrates	(R)-warfarin, (S)-Warfarin, Aceclofenac, Acenocoumarol, Acetohexamide, Acetylsalicylic acid, Alosetron, Alprazolam, Aminophenazone, Amitriptyline, Amprenavir, Antipyrine, Apixaban, Arachidonic Acid, Arformoterol, Artemether, Asunaprevir, Atazanavir, Avapritinib, Azelastine, Bioallethrin, Bortezomib, Bosentan, Brivaracetam, Buprenorphine, Bupropion, Cabozantinib, Caffeine, Candesartan, Candesartan cilexetil, Cannabidiol, Capecitabine, Capravirine, Carbutamide, Carvedilol, Celecoxib, Chlorpropamide, Cinnarizine, Clopidogrel, Clozapine, Coumarin, Cyclophosphamide, Dacomitinib, Dapagliflozin, Dapsone, Desogestrel, Dexibuprofen, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Dicoumarol, Diphenhydramine, Doconexent, Dolasetron, Donepezil, Dorzolamide, Doxazosin, Doxepin, Dronabinol, Duloxetine, Eletriptan, Enasidenib, Enzalutamide, Erdafitinib, Esketamine, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Estrone sulfate, Ethinylestradiol, Etodolac, Etoricoxib, Etravirine, Fenfluramine, Fluindione, Flunarizine, Flunitrazepam, Fluoxetine, Flurbiprofen, Fluvastatin, Formoterol, Fosphenytoin, Glibornuride, Gliclazide, Glimepiride, Glipizide, Gliquidone, Glisoxepide, Glyburide, Haloperidol, Halothane, Hexobarbital, Hydromorphone, Ibuprofen, Idarubicin, Ifosfamide, Imatinib, Indisulam, Indomethacin, Irbesartan, Istradefylline, Ixazomib, Ketamine, Ketobemidone, Ketoprofen, Ketorolac, Lacosamide, Leflunomide, Lesinurad, Licofelone, Lidocaine, Lonafarnib, Loratadine, Lornoxicam, Losartan, Lumiracoxib, Lynestrenol, Medical Cannabis, Mefenamic acid, Melatonin, Meloxicam, Mephenytoin, Mestranol, Metahexamide, Methadone, Methoxyflurane, Moclobemide, Montelukast, Nabiximols, Nabumetone, Naproxen, Nateglinide, Netupitant, Niclosamide, Nicotine, Norgestimate, Oliceridine, Olodaterol, Omeprazole, Ondansetron, Ospemifene, Paramethadione, Parecoxib, Perphenazine, Phenacetin, Phenobarbital, Phenprocoumon, Phenylbutazone, Phenytoin, Piperaquine, Pirfenidone, Piroxicam, Pitavastatin, Prasugrel, Primidone, Progesterone, Proguanil, Promazine, Propacetamol, Propofol, Quazepam, Quinidine, Quinine, Ramelteon, Rimegepant, Rofecoxib, Rosiglitazone, Rosuvastatin, Rupatadine, Salicylic acid, Selegiline, Selumetinib, Seratrodast, Sertraline, Sildenafil, Siponimod, Sitaxentan, Sulfamethoxazole, Suprofen, Tamoxifen, Tapentadol, Temazepam, Tenoxicam, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiamylal, Tolazamide, Tolbutamide, Tolterodine, Torasemide, Trabectedin, Tranilast, Treprostinil, Tretinoin, Triclabendazole, Trifarotene, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Umifenovir, Valdecoxib, Valproic acid, Valsartan, Verapamil, Vicriviroc, Vismodegib, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Ximelagatran, Zafirlukast, Zaltoprofen, Zidovudine, Zileuton, Zolpidem, Zopiclone
3	Cytochrome P450 2C9 inducers	Alpelisib, Apalutamide, Aprepitant, Avatrombopag, Betamethasone, Bosentan, Budesonide, Carbamazepine, Dabrafenib, Dapsone, Delafloxacin, Enzalutamide, Etravirine, Fosaprepitant, Fosphenytoin, Hydrocortisone, Isavuconazole, Ivosidenib, Lansoprazole, Letermovir, Lopinavir, Lumacaftor, Methylprednisolone, Midostaurin, Modafinil, Nevirapine, Nifedipine, Peginterferon alfa-2b, Phenobarbital, Phenytoin, Pralsetinib, Prednisolone phosphate, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Secobarbital, Vigabatrin, Warfarin
4	Cytochrome P450 2C9 inactivators	Suprofen

	Interacting Group	Interacting Drugs
	Pexidartinib is a UDP-glucuronosyltransferase 1-1 inhibitor
1	UDP-glucuronosyltransferase 1-1 substrates	Abacavir, Acetaminophen, Alvocidib, Atorvastatin, Axitinib, Bictegravir, Binimetinib, Carvedilol, Cerivastatin, Deferasirox, Delafloxacin, Dexibuprofen, Dolutegravir, Eltrombopag, Enasidenib, Eslicarbazepine, Eslicarbazepine acetate, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethinylestradiol, Etoposide, Ezetimibe, Ezogabine, Flurbiprofen, Fluvastatin, Fulvestrant, Furosemide, Fusidic acid, Gavestinel, Gemfibrozil, Glipizide, Indacaterol, Indomethacin, Irinotecan, Ketoprofen, Labetalol, Letermovir, Levothyroxine, Liothyronine, Losartan, Lovastatin, Metronidazole, Migalastat, Minoxidil, Morphine, Muraglitazar, Mycophenolate mofetil, Mycophenolic acid, Naloxone, Naltrexone, Nintedanib, Norgestimate, Phenytoin, Propacetamol, Propofol, Raloxifene, Raltegravir, Sacituzumab govitecan, Selumetinib, Simvastatin, Suprofen, Tecovirimat, Tiagabine, Tramadol, Troglitazone, Valproic acid, Zidovudine, Zonisamide
2	UDP-glucuronosyltransferase 1-1 inhibitors	Adenine, Atazanavir, Dacomitinib, Deferasirox, Eltrombopag, Enasidenib, Erlotinib, Ertugliflozin, Flunitrazepam, Flurbiprofen, Fostamatinib, Gemfibrozil, Glecaprevir, Indinavir, Indomethacin, Ketoconazole, Nilotinib, Paritaprevir, Pazopanib, Pibrentasvir, Probenecid, Propofol, Regorafenib, Rucaparib, Silibinin, Sodium aurothiomalate, Sorafenib, Ubrogepant, Valproic acid
3	UDP-glucuronosyltransferase 1-1 inducers	Carbamazepine, Desogestrel, Efavirenz, Ethinylestradiol, Nelfinavir, Phenobarbital, Phenytoin, Rifampicin, Testosterone propionate, Tipranavir, Zidovudine

	Interacting Group	Interacting Drugs
	Pexidartinib is a Multidrug and toxin extrusion protein 1 inhibitor
1	Multidrug and toxin extrusion protein 1 substrates	Acyclovir, Cefradine, Cephalexin, Cimetidine, Ciprofloxacin, Emtricitabine, Estrone sulfate, Flecainide, Ganciclovir, Guanidine, Levofloxacin, Metformin, N-methylnicotinamide, Nadolol, Procainamide, Relebactam, Tetraethylammonium, Tipiracil, Topotecan, Trimethoprim
2	Multidrug and toxin extrusion protein 1 inhibitors	Abemaciclib, Apalutamide, Bictegravir, Brigatinib, Capmatinib, Cimetidine, Ciprofloxacin, Famotidine, Fedratinib, Flecainide, Gilteritinib, Glasdegib, Guanfacine, Istradefylline, Lasmiditan, Levofloxacin, Lofexidine, Methylene blue, Osilodrostat, Pemigatinib, Plazomicin, Pralsetinib, Pyrimethamine, Ranolazine, Remdesivir, Rifamycin, Rimegepant, Ripretinib, Risdiplam, Rucaparib, Selpercatinib, Tafenoquine, Tazemetostat, Tirbanibulin, Topotecan, Trimethoprim, Tucatinib, Verapamil

	Interacting Group	Interacting Drugs
	Pexidartinib is a Multidrug and toxin extrusion protein 2 inhibitor
1	Multidrug and toxin extrusion protein 2 substrates	Acyclovir, Baricitinib, Cimetidine, Estrone sulfate, Ganciclovir, Metformin, N-methylnicotinamide, Nadolol, Procainamide, Relebactam, Topotecan, Trastuzumab deruxtecan, Trimethoprim
2	Multidrug and toxin extrusion protein 2 inhibitors	Abemaciclib, Apalutamide, Baricitinib, Brigatinib, Capmatinib, Cimetidine, Ciprofloxacin, Copanlisib, Fedratinib, Glasdegib, Istradefylline, Lasmiditan, Levofloxacin, Methylene blue, Plazomicin, Pralsetinib, Pyrimethamine, Ranolazine, Risdiplam, Rucaparib, Tafenoquine, Tazemetostat, Tirbanibulin, Trimethoprim, Tucatinib, Verapamil

	Interacting Group	Interacting Drugs
	Pexidartinib is a Solute carrier organic anion transporter family member 1B1 inhibitor
1	Solute carrier organic anion transporter family member 1B1 substrates	Ambrisentan, Asunaprevir, Atorvastatin, Axitinib, Belantamab mafodotin, Benzylpenicillin, Cerivastatin, Cholecystokinin, Cholic Acid, Clotrimazole, Cobimetinib, Conjugated estrogens, Cyclosporine, Digoxin, Dinoprostone, Elagolix, Eluxadoline, Empagliflozin, Erythromycin, Ezetimibe, Fexofenadine, Fimasartan, Fluvastatin, Gadoxetic acid, Gimatecan, Glecaprevir, Grazoprevir, Letermovir, Levomenol, Levosalbutamol, Liothyronine, Liotrix, Lovastatin, Methotrexate, Mycophenolate mofetil, Olmesartan, Ouabain, Paritaprevir, Penicillamine, Pitavastatin, Prasterone, Pravastatin, Raloxifene, Remdesivir, Repaglinide, Revefenacin, Rosuvastatin, Selexipag, Simeprevir, Simvastatin, Sumatriptan, Taurocholic acid, Technetium Tc-99m mebrofenin, Tenofovir alafenamide, Torasemide, Ubrogepant, Valsartan, Voxilaprevir
2	Solute carrier organic anion transporter family member 1B1 inhibitors	Acetylcysteine, Aminohippuric acid, Amprenavir, Artesunate, Asunaprevir, Atazanavir, Atorvastatin, Axitinib, Beclomethasone dipropionate, Bempedoic acid, Benzbromarone, Bezafibrate, Cabazitaxel, Candesartan, Caspofungin, Cerivastatin, Cholecystokinin, Cholic Acid, Clarithromycin, Clotrimazole, Cobicistat, Conjugated estrogens, Cyclosporine, Dabrafenib, Daclatasvir, Darolutamide, Darunavir, Diclofenac, Diethylstilbestrol, Digoxin, Dipyridamole, Dovitinib, Dronedarone, Elexacaftor, Eltrombopag, Eluxadoline, Enasidenib, Erythromycin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Everolimus, Fedratinib, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fostemsavir, Gemfibrozil, Genistein, Glecaprevir, Hyperforin, Idelalisib, Indinavir, Indomethacin, Irinotecan, Istradefylline, Ivermectin, Ketoconazole, Lenvatinib, Levocarnitine, Levothyroxine, Lobeglitazone, Lonafarnib, Lopinavir, Lovastatin, Lurbinectedin, Mifepristone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Novobiocin, Nystatin, Osilodrostat, Ouabain, Paritaprevir, Pazopanib, Pibrentasvir, Pioglitazone, Pitavastatin, Posizolid, Pralsetinib, Progesterone, Quercetin, Quinidine, Quinine, Remdesivir, Reserpine, Rifampicin, Rifamycin, Rilpivirine, Rimegepant, Ritonavir, Rosiglitazone, Rosuvastatin, Rucaparib, Sacubitril, Saquinavir, Sildenafil, Silibinin, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Sulfasalazine, Tacrolimus, Taurocholic acid, Telaprevir, Telithromycin, Teriflunomide, Tipranavir, Tirbanibulin, Troglitazone, Ubrogepant, Upadacitinib, Valsartan, Valspodar, Velpatasvir, Venetoclax, Verapamil, Vinblastine, Vincristine, Voxilaprevir
3	Solute carrier organic anion transporter family member 1B1 inducers	Apalutamide, Cholic Acid, Taurocholic acid
4	Solute carrier organic anion transporter family member 1B1 weak inhibitors	Cobimetinib
5	Solute carrier organic anion transporter family member 1B1 transporters	Velpatasvir

	Interacting Group	Interacting Drugs
	Pexidartinib is a Solute carrier organic anion transporter family member 1B3 inhibitor
1	Solute carrier organic anion transporter family member 1B3 substrates	Ambrisentan, Atorvastatin, Belantamab mafodotin, Bempedoic acid, Caspofungin, Cholecystokinin, Cholic Acid, Cobimetinib, Conjugated estrogens, Docetaxel, Empagliflozin, Erythromycin, Fexofenadine, Fluvastatin, Gadoxetic acid, Glecaprevir, Grazoprevir, Letermovir, Levomenol, Levosalbutamol, Liothyronine, Liotrix, Methotrexate, Mycophenolate mofetil, Olmesartan, Ouabain, Paclitaxel, Parachlorophenol, Paritaprevir, Pitavastatin, Prasterone, Pravastatin, Raloxifene, Revefenacin, Rifampicin, Romidepsin, Selexipag, Simeprevir, Sincalide, Taurocholic acid, Technetium Tc-99m mebrofenin, Tenofovir alafenamide, Testosterone, Trastuzumab deruxtecan, Ubrogepant, Valsartan, Voxilaprevir
2	Solute carrier organic anion transporter family member 1B3 inhibitors	Asunaprevir, Ataluren, Atazanavir, Baricitinib, Beclomethasone dipropionate, Bempedoic acid, Bortezomib, Cabazitaxel, Clarithromycin, Cobicistat, Cobimetinib, Cyclosporine, Dabrafenib, Daclatasvir, Darolutamide, Dipyridamole, Dovitinib, Dronedarone, Elexacaftor, Enasidenib, Erythromycin, Everolimus, Fedratinib, Fostemsavir, Gemfibrozil, Ginsenoside Rb1, Glecaprevir, Idelalisib, Istradefylline, Ivermectin, Levothyroxine, Lonafarnib, Lopinavir, Lurbinectedin, Mifepristone, Nefazodone, Nelfinavir, Novobiocin, Nystatin, Paritaprevir, Pibrentasvir, Pioglitazone, Pralsetinib, Remdesivir, Rifampicin, Rifamycin, Rilpivirine, Rimegepant, Ritonavir, Rucaparib, Sacubitril, Selinexor, Silibinin, Simeprevir, Sulfasalazine, Telithromycin, Tipranavir, Tirbanibulin, Ubrogepant, Valspodar, Velpatasvir, Vincristine, Voxilaprevir
3	Solute carrier organic anion transporter family member 1B3 transporters	Velpatasvir
4	Solute carrier organic anion transporter family member 1B3 inducers	Clotrimazole, Progesterone

	Interacting Group	Interacting Drugs
	Pexidartinib is a Solute carrier organic anion transporter family member 2B1 inhibitor
1	Solute carrier organic anion transporter family member 2B1 inhibitors	Acetic acid, Alprostadil, Asunaprevir, Atazanavir, Benzbromarone, Benzoic acid, Bilastine, Cholecystokinin, Citric acid, Dipyridamole, Dovitinib, Erlotinib, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Gemfibrozil, Genistein, Indinavir, Itraconazole, Lactic acid, Levothyroxine, Naringenin, Nefazodone, Nelfinavir, Niacin, Novobiocin, Oxalic Acid, Phthalic Acid, Piroxicam, Quercetin, Reserpine, Rifampicin, Rifamycin, Ritonavir, Saquinavir, Silibinin, Sulfasalazine, Telaprevir, Tetracycline, Tipranavir, Valproic acid, Velpatasvir
2	Solute carrier organic anion transporter family member 2B1 substrates	Acetic acid, Asunaprevir, Atorvastatin, Benzylpenicillin, Conjugated estrogens, Diethylstilbestrol, Dinoprostone, Fexofenadine, Glyburide, Ibuprofen, Iloprost, Lactic acid, Latanoprostene bunod, Lifitegrast, Montelukast, Pitavastatin, Prasterone, Pravastatin, Salicylic acid, Simeprevir, Taurocholic acid, Tolbutamide
3	Solute carrier organic anion transporter family member 2B1 transporters	Velpatasvir