Liarozole

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Liarozole
Accession Number
DB13066
Type
Small Molecule
Groups
Investigational
Description

Liarozole has been used in trials studying the treatment of Ichthyosis, Lamellar.

Structure
Thumb
Synonyms
Not Available
Categories
UNII
K0Q29TGV9Y
CAS number
115575-11-6
Weight
Average: 308.77
Monoisotopic: 308.0828741
Chemical Formula
C17H13ClN4
InChI Key
UGFHIPBXIWJXNA-UHFFFAOYSA-N
InChI
InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21)
IUPAC Name
6-[(3-chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-1,3-benzodiazole
SMILES
ClC1=CC=CC(=C1)C(N1C=CN=C1)C1=CC=C2N=CNC2=C1

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Liarozole.Approved
AcetyldigoxinAcetyldigoxin may decrease the cardiotoxic activities of Liarozole.Experimental
BevacizumabBevacizumab may increase the cardiotoxic activities of Liarozole.Approved, Investigational
CabazitaxelThe risk or severity of adverse effects can be increased when Cabazitaxel is combined with Liarozole.Approved
Capromab pendetideLiarozole may decrease effectiveness of Capromab pendetide as a diagnostic agent.Approved
Choline C 11The therapeutic efficacy of Choline C 11 can be decreased when used in combination with Liarozole.Approved, Investigational
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Liarozole.Approved, Investigational
CymarinCymarin may decrease the cardiotoxic activities of Liarozole.Experimental
DeslanosideDeslanoside may decrease the cardiotoxic activities of Liarozole.Approved
DigitoxinDigitoxin may decrease the cardiotoxic activities of Liarozole.Approved, Investigational
DigoxinDigoxin may decrease the cardiotoxic activities of Liarozole.Approved
Digoxin Immune Fab (Ovine)Digoxin Immune Fab (Ovine) may decrease the cardiotoxic activities of Liarozole.Approved
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Liarozole.Approved, Investigational
GitoformateGitoformate may decrease the cardiotoxic activities of Liarozole.Experimental
Lanatoside CLanatoside C may decrease the cardiotoxic activities of Liarozole.Experimental
MetildigoxinMetildigoxin may decrease the cardiotoxic activities of Liarozole.Experimental
OleandrinOleandrin may decrease the cardiotoxic activities of Liarozole.Experimental, Investigational
OuabainOuabain may decrease the cardiotoxic activities of Liarozole.Approved
PaclitaxelThe risk or severity of adverse effects can be increased when Paclitaxel is combined with Liarozole.Approved, Vet Approved
PeruvosidePeruvoside may decrease the cardiotoxic activities of Liarozole.Experimental
ProscillaridinProscillaridin may decrease the cardiotoxic activities of Liarozole.Experimental
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Liarozole.Approved, Investigational
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
60652
PubChem Substance
347829194
ChemSpider
54664
BindingDB
50176808
ChEBI
135316
ChEMBL
CHEMBL389433

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2, 3CompletedTreatmentLamellar Ichthyosis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0179 mg/mLALOGPS
logP3.65ALOGPS
logP3.48ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)12.2ChemAxon
pKa (Strongest Basic)6.74ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area46.5 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity86.52 m3·mol-1ChemAxon
Polarizability31.54 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds).
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzimidazoles
Sub Class
Not Available
Direct Parent
Benzimidazoles
Alternative Parents
Chlorobenzenes / N-substituted imidazoles / Aryl chlorides / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds / Organochlorides / Hydrocarbon derivatives
Substituents
Benzimidazole / Chlorobenzene / Halobenzene / Aryl chloride / Aryl halide / Monocyclic benzene moiety / N-substituted imidazole / Benzenoid / Azole / Imidazole
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 20:36 / Updated on November 09, 2017 05:17