Identification
- Summary
Vitex agnus-castus fruit extract is a herbal product used to treat an irregular menstrual period, premenstrual symptoms, and mastodynia
- Generic Name
- Vitex agnus-castus fruit extract
- DrugBank Accession Number
- DB13193
- Background
Vitex agnus-castus fruit extract is obtained from dry fruits of Vitex agnus-castus. The fruits contain mixture of iridoids, flavonoids and compounds in leaves and flowers that structurally resemble sex hormones. Clinical studies demonstrates effectiveness of vitex agnus-castus fruit extract in the management of premenstrual stress syndrome (PMS) and cyclical breast pain (mastalgia). The main mechanism of action of vitex agnus-castus fruit extract has not been fully elucidated, however it is suggested to modulate the stress-induced prolactin secretion via dopaminergic actions, and μ (mu) - and δ (delta) -opioid receptors.
- Type
- Biotech
- Groups
- Experimental
- Biologic Classification
- Allergenics
Allergen Extract - Synonyms
- Agni casti fructus
- Chaste tree
Pharmacology
- Indication
Not Available
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Treatment of Breast pain ••• ••• Treatment of Menstrual cycle abnormal ••• ••• Treatment of Premenstrual syndrome ••• ••• - Contraindications & Blackbox Warnings
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Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
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Categories
- ATC Codes
- G02CX03 — Agni casti fructus
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 433OSF3U8A
- CAS number
- Not Available
References
- General References
- Schellenberg R: Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study The British Medical Journal. 2001 Jan 20;322:134-137. [Article]
- Meier B, Berger D, Hoberg E, Sticher O, Schaffner W: Pharmacological activities of Vitex agnus-castus extracts in vitro. Phytomedicine. 2000 Oct;7(5):373-81. [Article]
- Webster DE, He Y, Chen SN, Pauli GF, Farnsworth NR, Wang ZJ: Opioidergic mechanisms underlying the actions of Vitex agnus-castus L. Biochem Pharmacol. 2011 Jan 1;81(1):170-7. doi: 10.1016/j.bcp.2010.09.013. Epub 2010 Sep 18. [Article]
- TITCK Product Information: Agnucaston (fructus agni casti) film-coated tablet [Link]
- External Links
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Premenstrual Syndrome (PMS) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, film coated 20 MG Tablet Oral 4 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created at June 23, 2017 20:37 / Updated at June 05, 2021 09:12