Identification
- Generic Name
- Perboric acid
- DrugBank Accession Number
- DB13235
- Background
Perboric acid is mainly found in its salt form of sodium perborate and it can be found as a monohydrate or tetrahydrate.1 It is one of the peroxy acid salts with very wide functionalities in industrial settings.8 Perboric acid in the form of sodium perborate is approved by Health Canada since 2004 to be used as a disinfectant of medical instruments.3 By the FDA, sodium perborate is approved as an ointment for the protection of poison ivy dermatitis.4
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Perboric acid (DB13235)
- Weight
- Average: 59.82
Monoisotopic: 60.001874 - Chemical Formula
- BHO3
- Synonyms
- Not Available
Pharmacology
- Indication
In the industry, sodium perborate is used as a disinfectant. It is also part of the ingredients for detergents, bleach powders, and personal care formulations. In cosmetic products, perboric acid and mainly its salt are used as an oxidizing agent for dyeing or permanent waving.8
In dentistry, sodium perborate monohydrate is used as an aid for the removal of phlegm, mucus or other secretions associated with an occasional sore in the mouth, for cleansing minor wounds, for temporary cleanse of canker sore or for the removal of foreign materials in minor wounds.6
In ophthalmic preparations, sodium perborate is used as a preservative for products used for dry eye. This use is approved as this compound rapidly degrades to harmless byproducts.2
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Symptomatic treatment of Canker sores oral ••• ••• ••••••• ••• •••••••• For therapy Minor wounds ••• ••• ••••••• ••• •••••••• Symptomatic treatment of Wound of the oral cavity ••• ••• ••••••• ••• •••••••• Symptomatic treatment of Minor gum inflammation ••• ••• ••••••• ••• •••••••• Symptomatic treatment of Ulceration of the mouth ••• ••• ••••••• ••• •••••••• - Associated Therapies
- Contraindications & Blackbox Warnings
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No systemic effects are expected as it is highly unlikely that the substance will be systemically available.9
- Mechanism of action
Perboric acid acts as a source of active oxygen.5 In contact with water, perboric acid hydrolyzes to hydrogen and borate.2 As an antiseptic, the formation of hydrogen peroxide oxidizes the cellular components of the surrounding bacteria and kills them.7
- Absorption
Dermal absorption is assumed to be very low due to the high hydrophilicity of perboric acid and its ionic nature.9
- Volume of distribution
As perboric acid and its sodium salt are rapidly degraded in the body, this pharmacokinetic property is studied in the terms of Sodium carbonate and Hydrogen peroxide.
- Protein binding
As perboric acid and its sodium salt are rapidly degraded in the body, this pharmacokinetic property is studied in the terms of Sodium carbonate and Hydrogen peroxide.
- Metabolism
If perboric acid or its sodium salt get in touch with body fluids, they will rapidly dissociate into hydrogen peroxide, carbonate and sodium ions which are naturally present in the body. The produced hydrogen peroxide is rapidly degraded in blood and tissues. As carbonate is part of the normal buffer system of the body it is unlikely to be absorbed in amounts that could disturb the normal balance of the body. The rest of the dissociation products are also not thought to produce any significant systemic modifications.9
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- Route of elimination
As perboric acid and its sodium salt are rapidly degraded in the body, this pharmacokinetic property is studied in the terms of Sodium carbonate and Hydrogen peroxide.
- Half-life
As perboric acid and its sodium salt are rapidly degraded in the body, this pharmacokinetic property is studied in the terms of Sodium carbonate and Hydrogen peroxide.
- Clearance
As perboric acid and its sodium salt are rapidly degraded in the body, this pharmacokinetic property is studied in the terms of Sodium carbonate and Hydrogen peroxide.[
- Adverse Effects
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Acute oral and dermal LD50 are 1500 mg/kg and >2000 mg/kg, respectively. The toxicity of perboric acid and its salt is thought to be local and reported to be slight irritation of the skin which can be explained by the release of hydrogen peroxide. Mutagenicity, fertility and carcinogenicity studies have not been performed but it is thought that the potential of perboric acid to produce mutagenic, fertility or carcinogenic effects is unlikely.9
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
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Ingredient UNII CAS InChI Key Sodium perborate Y52BK1W96C 7632-04-4 YKLJGMBLPUQQOI-UHFFFAOYSA-M Sodium perborate monohydrate Y9UKD0XE6F 10332-33-9 MDGXUEVTGARGDK-UHFFFAOYSA-M - Active Moieties
Name Kind UNII CAS InChI Key Borate ion ionic 44OAE30D22 12258-53-6 GDTSJMKGXGJFGQ-UHFFFAOYSA-N - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Amosan Oral Wound Cleanser Powder, for solution 1.2 g/1.7g Oral Vintage Brands Limited 2017-12-01 Not applicable US 
Amosan Wound Cleanser Cherry Flavour Powder, for solution 1.2 g/1.7g Oral Vintage Brands Limited 2019-06-01 Not applicable US
Categories
- ATC Codes
- A01AB19 — Sodium perborate
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as metalloid oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is a metalloid.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Metalloid organides
- Sub Class
- Metalloid oxides
- Direct Parent
- Metalloid oxides
- Alternative Parents
- Metalloid salts / Inorganic salts / Inorganic oxides
- Substituents
- Inorganic metalloid salt / Inorganic oxide / Inorganic salt / Metalloid oxide
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- HC4C3M1FO2
- CAS number
- 14034-78-7
- InChI Key
- PEYVWSJAZONVQK-UHFFFAOYSA-N
- InChI
- InChI=1S/BHO3/c2-1-4-3/h3H
- IUPAC Name
- boranoylperoxol
- SMILES
- OOB=O
References
- General References
- Valera MC, Camargo CH, Carvalho CA, de Oliveira LD, Camargo SE, Rodrigues CM: Effectiveness of carbamide peroxide and sodium perborate in non-vital discolored teeth. J Appl Oral Sci. 2009 May-Jun;17(3):254-61. [Article]
- Troy B. and Beringer P. (2006). Remington: The Science and Practice of Pharmacy (21st ed.). Lippincott Williams & Wilkins.
- Health Canada [Link]
- FDA Poisonous Plant Database [Link]
- Manufacturer [Link]
- DailyMed Label: AMOSAN (Sodium perborate monohydrate) oral wound cleanser [Link]
- EPA [Link]
- Technical data sheet [File]
- OECD SIDS [File]
- External Links
- ChemSpider
- 102872
- ChEBI
- 30175
- ChEMBL
- CHEMBL3707334
- ZINC
- ZINC000256057132
- Wikipedia
- Sodium_perborate
- MSDS
- Download (47.1 KB)
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Powder, for solution Oral 1.2 g/1.7g - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 63 ºC but decomposes at 60 ºC 'MSDS' boiling point (°C) 130-150 ºC but decomposes at 60 ºC 'MSDS' water solubility 23 g/L 'MSDS' - Predicted Properties
Property Value Source logP 0.48 Chemaxon pKa (Strongest Acidic) 7.47 Chemaxon pKa (Strongest Basic) -6.1 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 46.53 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 5.36 m3·mol-1 Chemaxon Polarizability 4.27 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at June 23, 2017 20:38 / Updated at April 24, 2024 13:53