This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Olaflur is a fluoride treatment for patients at risk of dental caries, sensitive teeth, or enamel decalcification.
- Generic Name
- Olaflur
- DrugBank Accession Number
- DB13290
- Background
Olaflur which is also referred to as elmex gel is an ingredient used in toothpaste which helps in the prevention of dental caries.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Olaflur (DB13290)
- Weight
- Average: 498.785
Monoisotopic: 498.457200126 - Chemical Formula
- C27H60F2N2O3
- Synonyms
- Olaflur
- External IDs
- SK&F 38095
- SK&F-38095
- SKF-38095
Pharmacology
- Indication
Not Available
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Symptomatic treatment of Decalcification; teeth ••• ••• ••• Prophylaxis of Dental decay ••• ••• ••• Symptomatic treatment of Tooth hypersensitivity ••• ••• ••• - Associated Therapies
- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image elmex Zahngel Olaflur (3.032 g/100g) + Dectaflur (0.287 g/100g) + Sodium fluoride (2.21 g/100g) Gel Dental Cp Gaba Gmb H 1986-06-03 Not applicable Austria 
Categories
- ATC Codes
- A01AA03 — Olaflur
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom.
- Kingdom
- Organic compounds
- Super Class
- Organic nitrogen compounds
- Class
- Organonitrogen compounds
- Sub Class
- Amines
- Direct Parent
- 1,2-aminoalcohols
- Alternative Parents
- Trialkylamines / Primary alcohols / Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- 1,2-aminoalcohol / Alcohol / Aliphatic acyclic compound / Hydrocarbon derivative / Organic oxygen compound / Organooxygen compound / Organopnictogen compound / Primary alcohol / Tertiary aliphatic amine / Tertiary amine
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 8NY9L8837D
- CAS number
- 6818-37-7
- InChI Key
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N
- InChI
- InChI=1S/C27H58N2O3.2FH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-28(22-25-30)20-18-21-29(23-26-31)24-27-32;;/h30-32H,2-27H2,1H3;2*1H
- IUPAC Name
- 2-({3-[bis(2-hydroxyethyl)amino]propyl}(octadecyl)amino)ethan-1-ol dihydrofluoride
- SMILES
- F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO
References
- General References
- AIFA Package Leaflet: ELMEX (Olaflur) dental gel [Link]
- External Links
- ChemSpider
- 21751
- ChEMBL
- CHEMBL2106575
- Wikipedia
- Olaflur
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Gel Dental Gel Dental - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0017 mg/mL ALOGPS logP 6.38 ALOGPS logP 5.75 Chemaxon logS -5.4 ALOGPS pKa (Strongest Acidic) 15.12 Chemaxon pKa (Strongest Basic) 9.72 Chemaxon Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 67.17 Å2 Chemaxon Rotatable Bond Count 27 Chemaxon Refractivity 140.04 m3·mol-1 Chemaxon Polarizability 61.94 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 211.98949 predictedDeepCCS 1.0 (2019) [M+H]+ 214.53983 predictedDeepCCS 1.0 (2019) [M+Na]+ 220.88274 predictedDeepCCS 1.0 (2019)
Drug created at June 23, 2017 20:39 / Updated at June 05, 2021 09:13