This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Flutrimazole is a topical antifungal used to treat pityriasis capitis and seborrheic dermatitis.
- Generic Name
- Flutrimazole
- DrugBank Accession Number
- DB13425
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Flutrimazole (DB13425)
- Weight
- Average: 346.381
Monoisotopic: 346.128154849 - Chemical Formula
- C22H16F2N2
- Synonyms
- flutrimazol
- Flutrimazole
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Treatment of Candidiasis of skin nos •••••••••••• •••••• ••••••• •••••• ••••• Treatment of Dandruff •••••••••••• •••••• ••••••• ••••••• Treatment of Pityriasis •••••••••••• ••• Treatment of Pityriasis versicolor •••••••••••• •••••• ••••••• •••••• ••••• Treatment of Seborrheic dermatitis •••••••••••• ••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
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Categories
- ATC Codes
- G01AF18 — Flutrimazole
- G01AF — Imidazole derivatives
- G01A — ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
- G01 — GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
- G — GENITO URINARY SYSTEM AND SEX HORMONES
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as triphenyl compounds. These are aromatic compounds containing a triphenyl moiety.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Triphenyl compounds
- Sub Class
- Not Available
- Direct Parent
- Triphenyl compounds
- Alternative Parents
- Fluorobenzenes / N-substituted imidazoles / Aryl fluorides / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds / Organofluorides / Hydrocarbon derivatives
- Substituents
- Aromatic heteromonocyclic compound / Aryl fluoride / Aryl halide / Azacycle / Azole / Fluorobenzene / Halobenzene / Heteroaromatic compound / Hydrocarbon derivative / Imidazole
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- imidazoles, imidazole antifungal drug, monofluorobenzenes (CHEBI:82864)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 776S0UP252
- CAS number
- 119006-77-8
- InChI Key
- QHMWCHQXCUNUAK-UHFFFAOYSA-N
- InChI
- InChI=1S/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H
- IUPAC Name
- 1-[(2-fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole
- SMILES
- FC1=CC=C(C=C1)C(N1C=CN=C1)(C1=CC=CC=C1)C1=CC=CC=C1F
References
- General References
- Not Available
- External Links
- ChemSpider
- 3284
- BindingDB
- 50436201
- 61773
- ChEBI
- 82864
- ChEMBL
- CHEMBL2107430
- Wikipedia
- Flutrimazole
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Gel Cutaneous Cream Topical 1.000 g Gel Topical Gel Topical 1.000 g Solution Cutaneous 1.000 g Solution Topical Cream Topical Shampoo Topical Spray Topical Gel Topical 1 g Solution Topical 1 g - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.000894 mg/mL ALOGPS logP 4.73 ALOGPS logP 5.52 Chemaxon logS -5.6 ALOGPS pKa (Strongest Basic) 6.62 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 17.82 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 99.39 m3·mol-1 Chemaxon Polarizability 34.59 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-0ufr-7090000000-61d4a8946db1f8511b44 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-004i-0090000000-9215f9b6713713089f4b Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0002-0009000000-18c54a8200d82b927856 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-004i-0090000000-7c46efc4ed42c8d0a8f6 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-004i-0091000000-88e0d0a10f29ac6acafc Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0002-0009000000-ac6194ad0de6514bdf5f Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-014j-2279000000-c05dbf26aaf3d929fc7f Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 175.24507 predictedDeepCCS 1.0 (2019) [M+H]+ 177.60307 predictedDeepCCS 1.0 (2019) [M+Na]+ 184.46019 predictedDeepCCS 1.0 (2019)
Drug created at June 23, 2017 20:41 / Updated at May 05, 2021 20:31