| 1 | Cytochrome P450 3A4 substrates | (R)-warfarin, (S)-Warfarin, 16-Bromoepiandrosterone, 3,5-diiodothyropropionic acid, 4-hydroxycoumarin, 5-androstenedione, 6-O-benzylguanine, Abemaciclib, Abiraterone, Acenocoumarol, Acetaminophen, Adinazolam, Agmatine, Albendazole, Alclometasone, Aldosterone, Alfentanil, Alfuzosin, Aliskiren, Allylestrenol, Almotriptan, Alogliptin, Alosetron, alpha-Tocopherol acetate, Alprazolam, Ambrisentan, Ambroxol, Amcinonide, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Androstenedione, Antipyrine, Apalutamide, Apixaban, Apremilast, Aprepitant, Aranidipine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Asenapine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Avanafil, Axitinib, Azelastine, Azelnidipine, Azithromycin, Balaglitazone, Banoxantrone, Baricitinib, Barnidipine, Beclomethasone dipropionate, Bedaquiline, Bencyclane, Benidipine, Benzphetamine, Bepridil, Betamethasone, Bexarotene, Bezafibrate, Bicalutamide, Bictegravir, Bioallethrin, Bisoprolol, Blonanserin, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromazepam, Bromocriptine, Brompheniramine, Budesonide, Bupivacaine, Buprenorphine, Bupropion, Buspirone, Busulfan, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calcitriol, Canagliflozin, Cannabidiol, Carbamazepine, Carbinoxamine, Carboxyamidotriazole, Cariprazine, Caroverine, Carvedilol, Caspofungin, Celecoxib, Cephalexin, Ceritinib, Cerivastatin, Cevimeline, Chenodeoxycholic acid, Chlordiazepoxide, Chlormadinone, Chloroquine, Chlorpheniramine, Chlorpromazine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Ciglitazone, Cilnidipine, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clobetasol, Clobetasol propionate, Clobetasone, Clofazimine, Clofibrate, Clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepic acid, Clorindione, Clotiazepam, Clozapine, Cobicistat, Cobimetinib, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Corticosterone, Corticotropin, Cortisone acetate, Crizotinib, Cyclandelate, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Cytarabine, Dabrafenib, Daclatasvir, Dantrolene, Dapagliflozin, Dapoxetine, Dapsone, Darifenacin, Darodipine, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delamanid, Delavirdine, Demegestone, Desogestrel, Desonide, Desoxycorticosterone acetate, Desoxycorticosterone pivalate, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexamethasone isonicotinate, Dexchlorpheniramine maleate, Dexlansoprazole, Dexniguldipine, Dextromethorphan, Dextropropoxyphene, Dexverapamil, Diazepam, Diclofenac, Dienogest, Diethylstilbestrol, Difluocortolone, Difluprednate, Digitoxin, Digoxin, Dihydro-alpha-ergocryptine, Dihydrocodeine, Dihydroergocornine, Dihydroergocristine, Dihydroergocryptine, Dihydroergotamine, Diltiazem, Diphenadione, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Doravirine, Dorzolamide, Dotarizine, Doxepin, Doxorubicin, Dronabinol, Dronedarone, Drospirenone, Duloxetine, Dutasteride, Duvelisib, Dydrogesterone, Ebastine, Efavirenz, Efonidipine, Elbasvir, Eletriptan, Eliglustat, Elvitegravir, Emopamil, Enalapril, Enasidenib, Encorafenib, Enzalutamide, Eperisone, Epinastine, Eplerenone, Equilenin, Equilin, Eravacycline, Ergocalciferol, Ergoloid mesylate, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esomeprazole, Estazolam, Esterified estrogens, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinylestradiol, Ethosuximide, Ethyl biscoumacetate, Ethylmorphine, Ethynodiol diacetate, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Etynodiol, Everolimus, Exemestane, Famciclovir, Felbamate, Felodipine, Fendiline, Fenofibrate, Fentanyl, Fesoterodine, Finasteride, Fish oil, Flibanserin, Fludrocortisone, Fluindione, Flumethasone, Flunarizine, Flunisolide, Flunitrazepam, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluoxetine, Fluprednidene, Fluprednisolone, Flurandrenolide, Flurazepam, Fluspirilene, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fosphenytoin, Fostamatinib, Fulvestrant, Fusidic acid, Gabapentin, Galantamine, Gallopamil, Gefitinib, Gemfibrozil, Gestodene, Gestrinone, Glipizide, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halcinonide, Halofantrine, Haloperidol, Halothane, HE3286, Hexobarbital, Histamine, Hydrocodone, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydromorphone, Hydroxyprogesterone, Hydroxyprogesterone caproate, Ibrutinib, Icotinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indalpine, Indapamide, Indinavir, Ipecac, Ipratropium, Irinotecan, Isavuconazole, Isavuconazonium, Isosorbide dinitrate, Isosorbide mononitrate, Isradipine, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Ketoconazole, Lacidipine, Lacosamide, Lamotrigine, Lansoprazole, Lapatinib, Laquinimod, Lenvatinib, Lercanidipine, Letrozole, Leuprolide, Levacetylmethadol, Levetiracetam, Levobupivacaine, Levomenthol, Levomilnacipran, Levonorgestrel, Lidocaine, Lidoflazine, Linagliptin, Liothyronine, Liotrix, Lisuride, Lobeglitazone, Lomerizine, Lomitapide, Loperamide, Lopinavir, Loratadine, Lorcaserin, Lorpiprazole, Losartan, Loteprednol etabonate, Lovastatin, Lumefantrine, Lurasidone, Lynestrenol, Lysergic acid diethylamide, Macimorelin, Macitentan, Manidipine, Maraviroc, Mebendazole, Medical Cannabis, Medrogestone, Medroxyprogesterone acetate, Medrysone, Mefloquine, Megestrol acetate, Melengestrol, Meloxicam, Meperidine, Meprednisone, Mestranol, Methadone, Methaqualone, Methotrexate, Methoxyflurane, Methylergometrine, Methylprednisolone, Methyltestosterone, Methysergide, Mexiletine, Mianserin, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Mirabegron, Mirtazapine, Modafinil, Mometasone, Mometasone furoate, Montelukast, Morphine, Mycophenolate mofetil, Nabiximols, Naftopidil, Naloxegol, Nateglinide, Nefazodone, Nelfinavir, Neratinib, Netoglitazone, Netupitant, Nevirapine, Nicardipine, Nicotine, Nifedipine, Niguldipine, Nilotinib, Niludipine, Nilvadipine, Nimesulide, Nimodipine, Nintedanib, Nisoldipine, Nitrazepam, Nitrendipine, Nomegestrol, Nomegestrol acetate, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Nortriptyline, Nylidrin, Odanacatib, Olaparib, Olopatadine, Omeprazole, Ondansetron, Opium, Orphenadrine, Osimertinib, Ospemifene, Otilonium, Oxazepam, Oxybutynin, Oxycodone, Oxymorphone, Paclitaxel, Palbociclib, Paliperidone, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Pazopanib, Penfluridol, Perampanel, Pergolide, Perhexiline, Permethrin, Perospirone, Perphenazine, Phenacetin, Phenprocoumon, Phenytoin, Pimecrolimus, Pimozide, Pinacidil, Pinaverium, Pioglitazone, Piperaquine, Pipotiazine, Pitolisant, Pomalidomide, Ponatinib, Posaconazole, Pranlukast, Prasterone, Prasugrel, Prazepam, Praziquantel, Prednicarbate, Prednisolone, Prednisone, Prednylidene, Pregabalin, Pregnenolone, Prenylamine, Primaquine, Prochlorperazine, Progesterone, Proguanil, Promazine, Promegestone, Propacetamol, Propafenone, Propiverine, Propranolol, Pyrazinamide, Quazepam, Quetiapine, Quinacrine, Quingestanol, Quinidine, Quinine, Rabeprazole, Ramelteon, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Repaglinide, Retapamulin, Ribociclib, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rilpivirine, Rimexolone, Rimonabant, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Rivastigmine, Rivoglitazone, Rofecoxib, Roflumilast, Rolapitant, Romidepsin, Ropinirole, Ropivacaine, Rosiglitazone, Rosuvastatin, Rotigotine, Roxithromycin, Rucaparib, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Segesterone acetate, Selegiline, Seletracetam, Selexipag, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simeprevir, Simvastatin, Sirolimus, Sitagliptin, Solifenacin, Sonidegib, Sorafenib, Spiramycin, Sufentanil, Sulfadiazine, Sulfinpyrazone, Sunitinib, Suvorexant, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasimelteon, Tasosartan, Taurochenodeoxycholic acid, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Teniposide, Terbinafine, Terfenadine, Terguride, Terodiline, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone propionate, Testosterone undecanoate, Tetracycline, Tetrahydropalmatine, Tetrandrine, Tezacaftor, Theophylline, Thiamylal, Thiotepa, Tiagabine, Tianeptine, Ticagrelor, Ticlopidine, Tinidazole, Tiotropium, Tipranavir, Tocofersolan, Tocopherol, Tofacitinib, Tolfenamic acid, Tolterodine, Tolvaptan, Toremifene, Trabectedin, Tramadol, Tranilast, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Trilostane, Trimebutine, Trimethadione, Trimethoprim, Trimipramine, Troleandomycin, Udenafil, Ulipristal, Valbenazine, Valdecoxib, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinflunine, Vinorelbine, Vinpocetine, Vismodegib, Vorapaxar, Voriconazole, Vortioxetine, Voxilaprevir, Warfarin, WIN 55212-2, Yohimbine, Zaleplon, Ziconotide, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone, Zotepine, Zuclopenthixol |
| 2 | Cytochrome P450 3A4 inducers | Acetaminophen, Alimemazine, Aminoglutethimide, Apalutamide, Armodafinil, Artemether, Asunaprevir, Atorvastatin, Avasimibe, Azatadine, Barbital, Beclomethasone dipropionate, Betamethasone, Bexarotene, Bosentan, Budesonide, Calcitriol, Carbamazepine, Cefradine, Cerivastatin, Chlorphenesin, Clarithromycin, Clevidipine, Clobazam, Clobetasol, Clobetasol propionate, Clofibrate, Clotrimazole, Clozapine, Colchicine, Corticotropin, Cortisone acetate, Cyclophosphamide, Cyclosporine, Dabrafenib, Deferasirox, Delafloxacin, Desonide, Dexamethasone, Dexamethasone isonicotinate, Dicloxacillin, Drospirenone, Efavirenz, Eletriptan, Enasidenib, Enzalutamide, Eslicarbazepine acetate, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethanol, Etoposide, Etravirine, Felbamate, Flucloxacillin, Fludrocortisone, Flunisolide, Fluocinolone acetonide, Fluvastatin, Formestane, Fosaprepitant, Fosphenytoin, Genistein, Glycerol phenylbutyrate, Griseofulvin, Guanethidine, Hydrocortamate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Idelalisib, Ifosfamide, Isavuconazole, Isavuconazonium, Ivosidenib, Lansoprazole, Lenvatinib, Loratadine, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Meperidine, Metamizole, Methadone, Methylprednisolone, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Nafcillin, Nevirapine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Pantoprazole, Pegvisomant, Pentobarbital, Perampanel, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Pitolisant, Prednicarbate, Prednisolone, Prednisone, Primidone, Probenecid, Progesterone, Propacetamol, Pyridostigmine, Quinidine, Quinine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rimexolone, Ritonavir, Rofecoxib, Rufinamide, Sarilumab, Seratrodast, Siltuximab, St. John's Wort, Sulfinpyrazone, Tamoxifen, Temozolomide, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tocilizumab, Topiramate, Topotecan, Trametinib, Triamcinolone, Troglitazone, Vemurafenib, Vinblastine |
| 3 | Cytochrome P450 3A4 inhibitors | 6-Deoxyerythronolide B, Acalabrutinib, Acetaminophen, Acetazolamide, Albuterol, Aldesleukin, Amiodarone, Amphotericin B, Amprenavir, Anastrozole, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, Atomoxetine, AVE9633, Barnidipine, Benidipine, Bicalutamide, Bifonazole, Black cohosh, Boceprevir, Bortezomib, Bosutinib, Brefeldin A, Brentuximab vedotin, Bromocriptine, Bryostatin 1, Buprenorphine, Cabergoline, Candicidin, Capsaicin, Carbomycin, Ceritinib, Cerivastatin, Cethromycin, Chloramphenicol, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clotrimazole, Clozapine, Cobicistat, Colchicine, Coltuximab ravtansine, Conivaptan, Crizotinib, Curcumin, Cyclosporine, Cyproterone acetate, Dalfopristin, Danazol, Danoprevir, Dapoxetine, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Desogestrel, Desvenlafaxine, Dexamethasone, Dexamethasone isonicotinate, Dextropropoxyphene, Diazepam, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Dirithromycin, Docetaxel, Doramectin, Dovitinib, Doxorubicin, Doxycycline, Dronedarone, Duloxetine, Econazole, Efavirenz, Efonidipine, Elbasvir, Elvitegravir, Enasidenib, Epinephrine, Epofolate, Epothilone D, Eprinomectin, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Ethanol, Etoricoxib, Ezetimibe, Felodipine, Fidaxomicin, Fluconazole, Fluoxetine, Flurithromycin, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fostamatinib, Fusidic acid, Gefitinib, Glyburide, GPI-1485, Haloperidol, Histamine, Hydralazine, Idelalisib, Ifosfamide, Imatinib, Indalpine, Indinavir, Indisulam, Irbesartan, Isavuconazole, Isavuconazonium, Isoniazid, Isradipine, Itraconazole, Ivacaftor, Ivermectin, Ixabepilone, Josamycin, Ketazolam, Ketoconazole, Kitasamycin, KOS-1584, Lanreotide, Lansoprazole, Lapatinib, Lenvatinib, Lercanidipine, Lestaurtinib, Letermovir, Levofloxacin, Levosalbutamol, Linagliptin, Lomustine, Loperamide, Lopinavir, Loratadine, Lorvotuzumab mertansine, Losartan, Lovastatin, Luliconazole, Manidipine, Mefloquine, Mepartricin, Mequitazine, Methadone, Methazolamide, Methimazole, Methylergometrine, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Miocamycin, Mirtazapine, Mirvetuximab soravtansine, Mitemcinal, Mitoxantrone, Naloxone, Natamycin, Nefazodone, Nelfinavir, Netupitant, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nitrendipine, Nitric Oxide, Norfloxacin, Noscapine, Nystatin, Octreotide, Olanzapine, Olaparib, Oleandomycin, Omeprazole, Orphenadrine, Osimertinib, Oxetacaine, Oxybutynin, Oxymetholone, Palbociclib, Paramethasone, Paroxetine, Pasireotide, Patupilone, Pazopanib, Peppermint oil, Pergolide, Phenelzine, Pilocarpine, Pimecrolimus, Pimozide, Piperaquine, Posaconazole, Primaquine, Propacetamol, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Regorafenib, Remacemide, Resveratrol, Ribociclib, Ridaforolimus, Rilpivirine, Risperidone, Ritonavir, Rokitamycin, Rosuvastatin, Roxithromycin, Rucaparib, Rutin, Sagopilone, Saquinavir, Saracatinib, Sarilumab, Selamectin, Sertraline, Simeprevir, Simvastatin, Sitaxentan, Solithromycin, Somatostatin, Sorafenib, Spiramycin, Stiripentol, Sulfamethoxazole, Sulfanilamide, Sunitinib, Tamoxifen, Telaprevir, Telithromycin, Teniposide, Terfenadine, Tesmilifene, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetracycline, Thiopental, Tildipirosin, Tilmicosin, Tioconazole, Tipranavir, Tofisopam, Topiroxostat, Topotecan, Tranylcypromine, Trastuzumab emtansine, Troleandomycin, Tylosin, Tylvalosin, Valproic acid, Vapreotide, Venlafaxine, Verapamil, Vinblastine, Vincristine, Voriconazole, WIN 55212-2, Zafirlukast, Zimelidine, Ziprasidone |