Ethacizine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Ethacizine
Accession Number
DB13645
Type
Small Molecule
Groups
Experimental
Description
Not Available
Structure
Thumb
Synonyms
Not Available
External IDs
EZ-55 / NIK-244
Categories
UNII
FE5SPV1Z6G
CAS number
33414-33-4
Weight
Average: 413.54
Monoisotopic: 413.177312915
Chemical Formula
C22H27N3O3S
InChI Key
PQXGNJKJMFUPPM-UHFFFAOYSA-N
InChI
InChI=1S/C22H27N3O3S/c1-4-24(5-2)14-13-21(26)25-17-9-7-8-10-19(17)29-20-12-11-16(15-18(20)25)23-22(27)28-6-3/h7-12,15H,4-6,13-14H2,1-3H3,(H,23,27)
IUPAC Name
ethyl N-{10-[3-(diethylamino)propanoyl]-10H-phenothiazin-2-yl}carbamate
SMILES
CCOC(=O)NC1=CC2=C(SC3=CC=CC=C3N2C(=O)CCN(CC)CC)C=C1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcebutololAcebutolol may increase the arrhythmogenic activities of Ethacizine.
AcetyldigitoxinAcetyldigitoxin may increase the arrhythmogenic activities of Ethacizine.
AcetyldigoxinEthacizine may increase the arrhythmogenic activities of Acetyldigoxin.
AdenosineAdenosine may increase the arrhythmogenic activities of Ethacizine.
AgmatineAgmatine may increase the arrhythmogenic activities of Ethacizine.
AjmalineAjmaline may increase the arrhythmogenic activities of Ethacizine.
AlprenololAlprenolol may increase the arrhythmogenic activities of Ethacizine.
AmiodaroneAmiodarone may increase the arrhythmogenic activities of Ethacizine.
AmlodipineAmlodipine may increase the arrhythmogenic activities of Ethacizine.
AnisodamineAnisodamine may increase the arrhythmogenic activities of Ethacizine.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
96982
ChEBI
134732
ChEMBL
CHEMBL1997663
Wikipedia
Ethacizine
ATC Codes
C01BC09 — Ethacizine

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00945 mg/mLALOGPS
logP4.21ALOGPS
logP4ChemAxon
logS-4.6ALOGPS
pKa (Strongest Acidic)12.9ChemAxon
pKa (Strongest Basic)9.7ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area61.88 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity119.3 m3·mol-1ChemAxon
Polarizability44.86 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzothiazines
Sub Class
Phenothiazines
Direct Parent
Phenothiazines
Alternative Parents
Diarylthioethers / Beta amino acids and derivatives / Benzenoids / 1,4-thiazines / Tertiary carboxylic acid amides / Carbamate esters / Trialkylamines / Organic carbonic acids and derivatives / Azacyclic compounds / Organopnictogen compounds
show 3 more
Substituents
Phenothiazine / Beta amino acid or derivatives / Diarylthioether / Aryl thioether / Para-thiazine / Benzenoid / Tertiary carboxylic acid amide / Carbamic acid ester / Amino acid or derivatives / Carboxamide group
show 16 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on June 23, 2017 14:45 / Updated on September 02, 2019 20:04