Tacalcitol

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Tacalcitol is a vitamin D analog indicated in the treatment of mild to moderate plaque psoriasis.

Generic Name
Tacalcitol
DrugBank Accession Number
DB13689
Background

Not Available

Type
Small Molecule
Groups
Experimental, Investigational
Structure
Weight
Average: 416.646
Monoisotopic: 416.329045277
Chemical Formula
C27H44O3
Synonyms
  • Tacalcitol

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Treatment ofPsoriasis vulgaris (plaque psoriasis) of the scalp••••••••••••••••••••
Treatment ofMild, moderate psoriasis vulgaris (plaque psoriasis)••••••••••••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
Calcium acetateThe risk or severity of adverse effects can be increased when Tacalcitol is combined with Calcium acetate.
Calcium carbonateThe risk or severity of adverse effects can be increased when Tacalcitol is combined with Calcium carbonate.
Calcium chlorideThe risk or severity of adverse effects can be increased when Tacalcitol is combined with Calcium chloride.
Calcium citrateThe risk or severity of adverse effects can be increased when Tacalcitol is combined with Calcium citrate.
Calcium glubionate anhydrousThe risk or severity of adverse effects can be increased when Tacalcitol is combined with Calcium glubionate anhydrous.
Food Interactions
Not Available

Products

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Categories

ATC Codes
D05AX04 — Tacalcitol
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as vitamin d and derivatives. These are compounds containing a secosteroid backbone, usually secoergostane or secocholestane.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Vitamin D and derivatives
Direct Parent
Vitamin D and derivatives
Alternative Parents
Triterpenoids / Secondary alcohols / Cyclic alcohols and derivatives / Hydrocarbon derivatives
Substituents
Alcohol / Aliphatic homopolycyclic compound / Cyclic alcohol / Hydrocarbon derivative / Organic oxygen compound / Organooxygen compound / Secondary alcohol / Triterpenoid
Molecular Framework
Aliphatic homopolycyclic compounds
External Descriptors
Vitamin D3 and derivatives (LMST03020256)
Affected organisms
Not Available

Chemical Identifiers

UNII
C2W72OJ5ZU
CAS number
57333-96-7
InChI Key
BJYLYJCXYAMOFT-RSFVBTMBSA-N
InChI
InChI=1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1
IUPAC Name
(1R,3S,5Z)-5-{2-[(1R,3aS,4E,7aR)-1-[(2R,5R)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
SMILES
CC(C)[C@H](O)CC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C

References

General References
  1. BASG Product Information: Curatoderm (tacalcitol) topical [Link]
ChemSpider
4446823
BindingDB
50441892
RxNav
291204
ChEMBL
CHEMBL2105611
ZINC
ZINC000004474668
Wikipedia
Tacalcitol

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentPsoriasis Vulgaris (Plaque Psoriasis)2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
OintmentTopical4 μg/g
EmulsionTopical
OintmentTopical
EmulsionTopical4 MICROGRAMMI/G
EmulsionTopical4 mcg/g
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0105 mg/mLALOGPS
logP5.36ALOGPS
logP4.51Chemaxon
logS-4.6ALOGPS
pKa (Strongest Acidic)14.39Chemaxon
pKa (Strongest Basic)-1.1Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area60.69 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity126.29 m3·mol-1Chemaxon
Polarizability51.11 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-001j-0219000000-86687961dfb0c9dc5972
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-01q9-3429000000-0e20428b6dacaf0b3aad
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-014i-0000900000-7bddfbd471c9f867bf5c
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-00mp-3109200000-ef583b9fe050594c1fdb
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-01b9-1795000000-70b204aec5287369eac9
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-00bc-0309000000-262d3ecc58a289d4b64c
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-207.20891
predicted
DeepCCS 1.0 (2019)
[M+H]+209.10062
predicted
DeepCCS 1.0 (2019)
[M+Na]+214.70644
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:46 / Updated at May 29, 2021 18:12