NAV

Bemegride

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Bemegride
DrugBank Accession Number
DB13740
Background

Bemegride is a CNS stimulant that is used to induce convulsions in experimental animals. It has also been used as a respiratory stimulant and in the treatment of barbiturate overdose.

Type
Small Molecule
Groups
Experimental
Structure
3D
Similar Structures
Weight
Average: 155.197
Monoisotopic: 155.094628663
Chemical Formula
C8H13NO2
Synonyms
  • Bemegrida
  • Bemegride
  • Bemegridum
External IDs
  • NP13
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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International/Other Brands
Eukraton / Malysol / Megibal / Megimid / Megimide

Categories

ATC Codes
R07AB05 — Bemegride
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as piperidinediones. These are compounds containing a piperidine ring which bears two ketones.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Piperidines
Sub Class
Piperidinones
Direct Parent
Piperidinediones
Alternative Parents
Delta lactams / N-unsubstituted carboxylic acid imides / Dicarboximides / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Aliphatic heteromonocyclic compound / Azacycle / Carbonyl group / Carboxylic acid derivative / Carboxylic acid imide / Carboxylic acid imide, n-unsubstituted / Delta-lactam / Dicarboximide / Hydrocarbon derivative / Lactam
Molecular Framework
Aliphatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
57DQA39DO2
CAS number
64-65-3
InChI Key
ORRZGUBHBVWWOP-UHFFFAOYSA-N
InChI
InChI=1S/C8H13NO2/c1-3-8(2)4-6(10)9-7(11)5-8/h3-5H2,1-2H3,(H,9,10,11)
IUPAC Name
4-ethyl-4-methylpiperidine-2,6-dione
SMILES
CCC1(C)CC(=O)NC(=O)C1

References

General References
Not Available
ChemSpider
2220
ChEBI
92269
ChEMBL
CHEMBL1214192
ZINC
ZINC000001688939
Wikipedia
Bemegride

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility24.9 mg/mLALOGPS
logP0.44ALOGPS
logP0.48Chemaxon
logS-0.79ALOGPS
pKa (Strongest Acidic)11.8Chemaxon
pKa (Strongest Basic)-5.9Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area46.17 Å2Chemaxon
Rotatable Bond Count1Chemaxon
Refractivity40.51 m3·mol-1Chemaxon
Polarizability16.22 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-1900000000-020b8a80ac89675159f8
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-0900000000-5834d3db410519d5dca5
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-004l-3900000000-a85112fb66b8680fdb71
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-066r-9500000000-e547ffad96c6e7c83046
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-00kf-6900000000-46267ef85e382c4abbb7
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0690-9400000000-6a1dd59dccf6a1951d78
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-135.7798408
predicted
DarkChem Lite v0.1.0
[M-H]-136.06392
predicted
DeepCCS 1.0 (2019)
[M+H]+136.5098408
predicted
DarkChem Lite v0.1.0
[M+H]+139.8187
predicted
DeepCCS 1.0 (2019)
[M+Na]+135.9427408
predicted
DarkChem Lite v0.1.0
[M+Na]+148.99448
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:47 / Updated at February 21, 2021 18:54