Fenpiverinium

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Fenpiverinium is an anticholinergic agent indicated in the treatment of smooth muscle spasms.

Generic Name
Fenpiverinium
DrugBank Accession Number
DB13759
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 337.486
Monoisotopic: 337.227439982
Chemical Formula
C22H29N2O
Synonyms
Not Available

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to treatSmooth muscle spasmCombination Product in combination with: Pitofenone (DB15947)••••••••••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AclidiniumThe risk or severity of adverse effects can be increased when Fenpiverinium is combined with Aclidinium.
AdenosineThe risk or severity of Tachycardia can be increased when Adenosine is combined with Fenpiverinium.
AlfentanilThe risk or severity of adverse effects can be increased when Fenpiverinium is combined with Alfentanil.
AlloinThe therapeutic efficacy of Alloin can be decreased when used in combination with Fenpiverinium.
AmantadineThe risk or severity of adverse effects can be increased when Amantadine is combined with Fenpiverinium.
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Fenpiverinium bromide36479UA8GL125-60-0PMAHPMMCPXYARU-UHFFFAOYSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
จีนาลแกนFenpiverinium (0.1 MG) + Pitofenone (5 MG)Tabletบริษัท พอนด์ เคมีคอล จำกัด2015-11-192020-09-01Thailand flag
ฟาแกนFenpiverinium (0.1 MG) + Pitofenone (5 MG)Tabletบริษัท เอเชี่ยนยูเนี่ยนแล็บบอราตอรี่ จำกัด จำกัด1989-01-23Not applicableThailand flag
ฟิลิแกนเม็ดFenpiverinium (0.1 MG) + Pitofenone (5 MG)Tabletบริษัท วี แอนด์ พี ลาบอราตอรี่ จำกัด จำกัด1990-04-11Not applicableThailand flag

Categories

ATC Codes
A03AB21 — Fenpiverinium
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Diphenylmethanes
Direct Parent
Diphenylmethanes
Alternative Parents
Aralkylamines / Piperidines / Tetraalkylammonium salts / Carboximidic acids / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organic salts / Hydrocarbon derivatives / Organic cations
Substituents
Amine / Aralkylamine / Aromatic heteromonocyclic compound / Azacycle / Carboximidic acid / Carboximidic acid derivative / Diphenylmethane / Hydrocarbon derivative / Organic cation / Organic nitrogen compound
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
KP2L8LC73B
CAS number
258329-46-3
InChI Key
QDIYJDPBMZUZEH-UHFFFAOYSA-O
InChI
InChI=1S/C22H28N2O/c1-24(16-9-4-10-17-24)18-15-22(21(23)25,19-11-5-2-6-12-19)20-13-7-3-8-14-20/h2-3,5-8,11-14H,4,9-10,15-18H2,1H3,(H-,23,25)/p+1
IUPAC Name
1-(3-carbamoyl-3,3-diphenylpropyl)-1-methylpiperidin-1-ium
SMILES
C[N+]1(CCC(C(N)=O)(C2=CC=CC=C2)C2=CC=CC=C2)CCCCC1

References

General References
  1. FDA Thailand: DONAGAN (fenpiverinium and pitofenone) tablets [Link]
ChemSpider
64566
ChEBI
94773
ChEMBL
CHEMBL1884833
ZINC
ZINC000000001439
Wikipedia
Fenpiverinium

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility2.66e-05 mg/mLALOGPS
logP0.31ALOGPS
logP-0.56Chemaxon
logS-7.2ALOGPS
pKa (Strongest Acidic)16.19Chemaxon
pKa (Strongest Basic)-3.3Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count1Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area43.09 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity114.55 m3·mol-1Chemaxon
Polarizability38.92 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-170.94963
predicted
DeepCCS 1.0 (2019)
[M+H]+173.30763
predicted
DeepCCS 1.0 (2019)
[M+Na]+179.69267
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:48 / Updated at May 22, 2021 06:01