Clofibride

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Clofibride
Accession Number
DB13849
Type
Small Molecule
Groups
Experimental
Description
Not Available
Structure
Thumb
Synonyms
  • Clofibrida
  • Clofibridum
External IDs
MG 46
Categories
UNII
0S9SLS3L93
CAS number
26717-47-5
Weight
Average: 327.81
Monoisotopic: 327.1237359
Chemical Formula
C16H22ClNO4
InChI Key
CXQGFLBVUNUQIA-UHFFFAOYSA-N
InChI
InChI=1S/C16H22ClNO4/c1-16(2,22-13-9-7-12(17)8-10-13)15(20)21-11-5-6-14(19)18(3)4/h7-10H,5-6,11H2,1-4H3
IUPAC Name
3-(dimethylcarbamoyl)propyl 2-(4-chlorophenoxy)-2-methylpropanoate
SMILES
CN(C)C(=O)CCCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe risk or severity of bleeding can be increased when Clofibride is combined with (R)-warfarin.
(S)-WarfarinThe risk or severity of bleeding can be increased when Clofibride is combined with (S)-Warfarin.
4-hydroxycoumarinThe risk or severity of bleeding can be increased when Clofibride is combined with 4-hydroxycoumarin.
AcenocoumarolThe risk or severity of bleeding can be increased when Clofibride is combined with Acenocoumarol.
AcetohexamideThe risk or severity of hypoglycemia can be increased when Clofibride is combined with Acetohexamide.
AcipimoxThe risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Acipimox is combined with Clofibride.
Alendronic acidThe risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Alendronic acid is combined with Clofibride.
Aluminium clofibrateThe risk or severity of adverse effects can be increased when Aluminium clofibrate is combined with Clofibride.
AmiodaroneThe risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Amiodarone is combined with Clofibride.
Amphotericin BThe risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Amphotericin B is combined with Clofibride.
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
140758
ChEBI
135401
ChEMBL
CHEMBL1697831
Wikipedia
Clofibride
ATC Codes
C10AB10 — Clofibride

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0998 mg/mLALOGPS
logP3.21ALOGPS
logP2.69ChemAxon
logS-3.5ALOGPS
pKa (Strongest Basic)-1.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area55.84 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity84.54 m3·mol-1ChemAxon
Polarizability34.57 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as phenoxyacetic acid derivatives. These are compounds containing an anisole where the methane group is linked to an acetic acid or a derivative.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Phenoxyacetic acid derivatives
Direct Parent
Phenoxyacetic acid derivatives
Alternative Parents
Phenoxy compounds / Phenol ethers / Chlorobenzenes / Alkyl aryl ethers / N-acyl amines / Aryl chlorides / Tertiary carboxylic acid amides / Carboxylic acid esters / Monocarboxylic acids and derivatives / Organopnictogen compounds
show 5 more
Substituents
Phenoxyacetate / Phenoxy compound / Phenol ether / Alkyl aryl ether / Chlorobenzene / Halobenzene / Aryl chloride / Aryl halide / N-acyl-amine / Tertiary carboxylic acid amide
show 16 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available

Drug created on June 23, 2017 14:49 / Updated on November 02, 2018 07:47