Artemotil

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Artemotil
Accession Number
DB13851
Type
Small Molecule
Groups
Approved
Description

Artemotil (INN; also known as β-arteether), is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases. It is a semi-synthetic derivative of artemisinin, a natural product of the Chinese plant Artemisia annua.

Structure
Thumb
Synonyms
  • Arteether
  • beta-Arteether
  • beta-Dihydroartemisinin ethyl ether
  • Dihydroartemisinin ethyl ether
External IDs
SM 227
Categories
UNII
XGL7GFB9YI
CAS number
75887-54-6
Weight
Average: 312.406
Monoisotopic: 312.193674002
Chemical Formula
C17H28O5
InChI Key
NLYNIRQVMRLPIQ-XQLAAWPRSA-N
InChI
InChI=1S/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17-/m1/s1
IUPAC Name
(1R,4S,5R,8S,9R,10S,12R,13R)-10-ethoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane
SMILES
[H][C@@]12CC[C@@H](C)[C@]3([H])CC[C@@]4(C)OO[C@@]13[C@]([H])(O[C@H](OCC)[C@@H]2C)O4

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AcepromazineThe risk or severity of QTc prolongation can be increased when Artemotil is combined with Acepromazine.
AceprometazineThe risk or severity of QTc prolongation can be increased when Artemotil is combined with Aceprometazine.
AcetophenazineThe risk or severity of QTc prolongation can be increased when Artemotil is combined with Acetophenazine.
AlimemazineThe risk or severity of QTc prolongation can be increased when Artemotil is combined with Alimemazine.
ArtemetherThe risk or severity of QTc prolongation can be increased when Artemotil is combined with Artemether.
BL-1020The risk or severity of QTc prolongation can be increased when Artemotil is combined with BL-1020.
ButaperazineThe risk or severity of QTc prolongation can be increased when Artemotil is combined with Butaperazine.
ChlorproethazineThe risk or severity of QTc prolongation can be increased when Artemotil is combined with Chlorproethazine.
ChlorpromazineThe risk or severity of QTc prolongation can be increased when Artemotil is combined with Chlorpromazine.
CyamemazineThe risk or severity of QTc prolongation can be increased when Artemotil is combined with Cyamemazine.
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
2272064
BindingDB
50426305
ChEBI
135335
ChEMBL
CHEMBL301267
Wikipedia
Artemotil
ATC Codes
P01BE04 — Artemotil

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.276 mg/mLALOGPS
logP3.52ALOGPS
logP3.84ChemAxon
logS-3ALOGPS
pKa (Strongest Basic)-3.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area46.15 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity79.41 m3·mol-1ChemAxon
Polarizability34.08 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on June 23, 2017 14:49 / Updated on November 02, 2018 07:47