Phloxine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Phloxine B
Commonly known or available as Phloxine
Accession Number
DB13911
Type
Small Molecule
Groups
Approved
Description

Phloxine B (commonly known simply as phloxine, also known as D&C RED NO. 28) is a color additive which is used both as an inactive ingredient to provide color to products, or as a colorant in dental disclosing tablets. These tablets allow patients to visualise areas where more brushing and flossing are needed.

Structure
Thumb
Synonyms
  • CI Acid Red 92
  • Cyanosin
  • D&C Red No. 28
  • Disodium 2',4',5',7'-tetrabromo-4,5,6,7-tetrachlorofluorescein
  • Phloxine
External IDs
C.I. 45410
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Disclose Dry Handle SwabSwab1.5 %DentalBeutlich L.P.2000-11-302005-06-28Canada
Red-coteTablet5 mgDentalSunstar Americas1995-12-31Not applicableCanada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Categories
UNII
767IP0Y5NH
CAS number
18472-87-2
Weight
Average: 829.63
Monoisotopic: 823.518525
Chemical Formula
C20H2Br4Cl4Na2O5
InChI Key
GVKCHTBDSMQENH-UHFFFAOYSA-L
InChI
InChI=1S/C20H4Br4Cl4O5.2Na/c21-5-1-3-7(8-9(20(31)32)13(26)15(28)14(27)12(8)25)4-2-6(22)17(30)11(24)19(4)33-18(3)10(23)16(5)29;;/h1-2,29H,(H,31,32);;/q;2*+1/p-2
IUPAC Name
disodium 2,3,4,5-tetrachloro-6-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate
SMILES
[Na+].[Na+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C1C=C(Br)C([O-])=C2Br

Pharmacology

Indication

For use in dental disclosing products, allowing for highlighting of bacterial placques.

Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
2006228
ChEBI
87192
ChEMBL
CHEMBL61441
Wikipedia
Phloxine
AHFS Codes
  • 34:00.00 — Dental Agents

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
SwabDental1.5 %
TabletDental5 mg
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility7.49e-05 mg/mLALOGPS
logP7.71ALOGPS
logP8.16ChemAxon
logS-7ALOGPS
pKa (Strongest Acidic)2.52ChemAxon
pKa (Strongest Basic)1.84ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area89.49 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity174.48 m3·mol-1ChemAxon
Polarizability54.71 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzopyrans
Sub Class
1-benzopyrans
Direct Parent
Xanthenes
Alternative Parents
2-halobenzoic acids / 3-halobenzoic acids / 4-halobenzoic acids / Halobenzoic acids / Benzoic acids / 1-carboxy-2-haloaromatic compounds / Benzoyl derivatives / Phenoxides / Chlorobenzenes / Aryl bromides
show 14 more
Substituents
Xanthene / 2-halobenzoic acid or derivatives / 3-halobenzoic acid or derivatives / 4-halobenzoic acid or derivatives / Halobenzoic acid or derivatives / 2-halobenzoic acid / Halobenzoic acid / 4-halobenzoic acid / 3-halobenzoic acid / Benzoic acid or derivatives
show 32 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
organic sodium salt (CHEBI:87192)

Drug created on September 22, 2017 08:32 / Updated on July 16, 2019 06:23