Belladonna

Identification

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Name
Belladonna
Accession Number
DB13913
Type
Biotech
Groups
Approved, Experimental
Description

Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family Solanaceae. Its roots, leaves and fruits contain Hyoscyamine, Scopolamine, and mostly, Atropine. These alkaloids are naturally-occurring muscarinic antagonists. Atropine is a non-selective muscarinic antagonist that is mainly used as an adjunct for anaesthesia. The name "belladonna" originates from the Italian words "beautiful woman" and the historical use of herb eye-drops by women to dilate the pupils of the eyes for aesthetic purposes. Belladonna is a poisonous plant and belladonna intoxication from accidental ingestion may result in a severe anticholinergic syndrome, which is associated with both central and peripheral manifestations 1.

Synonyms
  • Atropa belladona
  • Atropa belladonna
  • Deadly nightshade
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Belladone TctTinctureOralLaboratoire Atlas Inc1951-12-312006-06-14Canada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Bellergal SpacetabsBelladonna (0.2 mg) + Ergotamine tartrate (0.6 mg) + Phenobarbital (40.0 mg)Tablet, extended releaseOralPaladin Labs Inc1959-01-012018-06-05Canada
Bellergal TabBelladonna (.1 mg) + Ergotamine (.3 mg) + Phenobarbital (20 mg)TabletOralSandoz1951-12-311997-08-12Canada
Cafergot Pb SupBelladonna (0.25 mg) + Caffeine (100 mg) + Ergotamine (2 mg) + Pentobarbital (60 mg)SuppositoryRectalNovartis1958-12-312003-01-15Canada
Cafergot Pb TabBelladonna (0.125 mg) + Caffeine (100 mg) + Ergotamine (1 mg) + Pentobarbital Sodium (30 mg)TabletOralNovartis1951-12-311999-08-04Canada
Hemorro-dol SupBelladonna (11.25 mg) + Balsam of Peru (22.6 mg) + Benzocaine (50 mg) + Bismuth subcarbonate (86.4 mg) + Bismuth subnitrate (37.8 mg) + Boric acid (226.7 mg) + Ephedrine sulfate (2.5 mg) + Zinc oxide (226.7 mg)SuppositoryRectalProduits Francais Labs Inc.1981-12-311997-05-30Canada
Opium and Belladonna SupBelladonna (15 mg) + Opium (65 mg)SuppositoryRectalSmithkline Beecham Pharma Division Of Smithkline Beecham Inc1993-12-311998-07-28Canada
PMS-opium and Belladona SupBelladonna (15 mg) + Opium (65 mg)SuppositoryRectalPharmascience Inc1991-12-312016-10-28Canada
Robol TabBelladonna (5.4 mg) + Alloin (16.2 mg) + Ipecac (4.32 mg) + Phenolphthalein (64.8 mg)TabletOralLabs Anglo French1979-12-311997-08-05Canada
Sandoz Opium & BelladonnaBelladonna (15 mg) + Opium (65 mg)SuppositoryRectalSandoz Canada Incorporated1991-12-31Not applicableCanada
Wigraine SuppositoriesBelladonna (.1 mg) + Caffeine (100 mg) + Ergotamine tartrate (1 mg)SuppositoryRectalOrganon Canada Ltd Ltee1981-12-311997-08-18Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Belladonna and OpiumBelladonna (16.2 mg/1) + Opium (30 mg/1)SuppositoryRectalPaddock Laboratories, LLC1994-05-01Not applicableUs
Belladonna and OpiumBelladonna (16.2 mg/1) + Opium (60 mg/1)SuppositoryRectalPaddock Laboratories, LLC1997-04-22Not applicableUs
Categories
UNII
WQZ3G9PF0H
CAS number
Not Available

Pharmacology

Indication

No therapeutic indications.

Associated Conditions
Pharmacodynamics

The active components of belladonna mediate anticholinergic actions. The main effects include inhibition of secretions such as dry mouth, tachycardia, pupillary dilation and paralysis of accommodation, relaxation of smooth muscles in the gut, bronchi, biliary tract and bladder (urinary retention), and inhibition of gastric acid secretion 3. Atropine is a stimulant of the central nervous system 3.

Mechanism of action

The active components of belladonna act as competitive antagonists at muscarinic receptors and block the binding of acetylcholine to the central nervous system and parasympathetic postganglionic muscarinic receptors 1.

Additional Data Available
Adverse Effects

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

For pharmacokinetic information of the active ingredients, refer to Atropine, Hyoscyamine, or Scopolamine.

Volume of distribution

For pharmacokinetic information of the active ingredients, refer to Atropine, Hyoscyamine, or Scopolamine.

Protein binding

For pharmacokinetic information of the active ingredients, refer to Atropine, Hyoscyamine, or Scopolamine.

Metabolism

For pharmacokinetic information of the active ingredients, refer to Atropine, Hyoscyamine, or Scopolamine.

Route of elimination

For pharmacokinetic information of the active ingredients, refer to Atropine, Hyoscyamine, or Scopolamine.

Half life

For pharmacokinetic information of the active ingredients, refer to Atropine, Hyoscyamine, or Scopolamine.

Clearance

For pharmacokinetic information of the active ingredients, refer to Atropine, Hyoscyamine, or Scopolamine.

Toxicity

Oral LD50 of atropine is 75 mg/kg in mouse. Clinical manifestations of anticholinergic syndrome include both central and peripheral effects. Central symptoms, which are dose-dependent and anticholinergic agent-specific, include ataxia, disorientation, short-term memory loss, confusion, hallucinations, psychosis, agitated delirium, seizures, coma, respiratory failure or cardiovascular collapse 1. Peripheral effects include mydriasis with cycloplegia, dry mucous membranes, hyperreflexia, flushed skin, diminished bowel sounds or ileus, urinary retention, tachycardia, and hypertension or hypotension 1. Management of anticholinergic intoxication should be symptomatic including gastrointestinal decontamination with activated charcoal 1. The antidote for belladonna poisoning is Physostigmine, which is the same as for atropine 1. Physosigmine crosses the blood-brain barrier and reversibly inhibits anticholinesterase. Benzodiazepines are frequently used for sedation to control anticholinergic effects including delirium and agitation 2.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
  1. Berdai MA, Labib S, Chetouani K, Harandou M: Atropa belladonna intoxication: a case report. Pan Afr Med J. 2012;11:72. Epub 2012 Apr 17. [PubMed:22655106]
  2. Demirhan A, Tekelioglu UY, Yildiz I, Korkmaz T, Bilgi M, Akkaya A, Kocoglu H: Anticholinergic Toxic Syndrome Caused by Atropa Belladonna Fruit (Deadly Nightshade): A Case Report. Turk J Anaesthesiol Reanim. 2013 Dec;41(6):226-8. doi: 10.5152/TJAR.2013.43. Epub 2013 May 23. [PubMed:27366377]
  3. 13. (2012). In Rang and Dale's Pharmacology (7th ed., pp. 159-161). Edinburgh: Elsevier/Churchill Livingstone. [ISBN:978-0-7020-3471-8]
External Links
RxNav
89781
Wikipedia
Belladonna
AHFS Codes
  • 12:08.08 — Antimuscarinics Antispasmodics

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3RecruitingTreatmentBreast Cancer1
4CompletedPreventionPainful Bladder Syndrome (PBS) / Urinary Bladder, Neurogenic / Urinary Bladder, Overactive / Urinary Urge Incontinence1
4CompletedTreatmentCalcium Nephrolithiasis1
4CompletedTreatmentHysterectomy / Postoperative pain1
4CompletedTreatmentPain1
4CompletedTreatmentVaginal Surgery1
4RecruitingTreatmentUrinary Tract Infection1
4TerminatedTreatmentUrinary Bladder, Overactive1
Not AvailableCompletedSupportive CareElective Cystoscopy / General Surgery / Ureteroscopy1
Not AvailableCompletedTreatmentPain / Pain Management1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
TinctureOral
SuppositoryRectal
Tablet, extended releaseOral
TabletOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Taxonomy

Classification
Not classified

Drug created on September 22, 2017 14:50 / Updated on February 25, 2020 00:21