Testosterone enantate benzilic acid hydrazone

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Testosterone enantate benzilic acid hydrazone
Accession Number
DB13947  (DBSALT002571)
Type
Small Molecule
Groups
Approved, Experimental
Description
Not Available
Structure
Thumb
Synonyms
  • Testosterone 17-enanthate 3-benzilic acid hydrazone
  • Testosterone enanthate benzilic acid hydrazone
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Climacteron InjectionTestosterone enantate benzilic acid hydrazone (150 mg) + Estradiol benzoate (1 mg) + Estradiol dienanthate (7.5 mg)LiquidIntramuscularSandoz Canada Incorporated1994-12-312005-10-20Canada
Categories
UNII
X8Z8A2G2Y4
CAS number
18625-33-7
Weight
Average: 624.866
Monoisotopic: 624.392708162
Chemical Formula
C40H52N2O4
InChI Key
PTVXYACXDYZNID-JKXGKYMWSA-N
InChI
InChI=1S/C40H52N2O4/c1-4-5-6-13-18-36(43)46-35-22-21-33-32-20-19-30-27-31(23-25-38(30,2)34(32)24-26-39(33,35)3)41-42-37(44)40(45,28-14-9-7-10-15-28)29-16-11-8-12-17-29/h7-12,14-17,27,32-35,45H,4-6,13,18-26H2,1-3H3,(H,42,44)/t32-,33-,34-,35-,38-,39-/m0/s1
IUPAC Name
(1S,3aS,3bR,9aR,9bS,11aS)-7-[(2-hydroxy-2,2-diphenylacetamido)imino]-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl heptanoate
SMILES
[H]N(N=C1CC[C@@]2(C)C(CC[C@@]3([H])[C@]4([H])CC[C@H](OC(=O)CCCCCC)[C@@]4(C)CC[C@]23[H])=C1)C(=O)C(O)(C1=CC=CC=C1)C1=CC=CC=C1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
Acetylsalicylic acidThe therapeutic efficacy of Acetylsalicylic acid can be increased when used in combination with Testosterone enantate benzilic acid hydrazone.
AlclometasoneThe risk or severity of edema formation can be increased when Testosterone enantate benzilic acid hydrazone is combined with Alclometasone.
AmcinonideThe risk or severity of edema formation can be increased when Testosterone enantate benzilic acid hydrazone is combined with Amcinonide.
AnagrelideThe therapeutic efficacy of Anagrelide can be increased when used in combination with Testosterone enantate benzilic acid hydrazone.
ArgatrobanThe therapeutic efficacy of Argatroban can be increased when used in combination with Testosterone enantate benzilic acid hydrazone.
Beclomethasone dipropionateThe risk or severity of edema formation can be increased when Testosterone enantate benzilic acid hydrazone is combined with Beclomethasone dipropionate.
BetamethasoneThe risk or severity of edema formation can be increased when Testosterone enantate benzilic acid hydrazone is combined with Betamethasone.
BudesonideThe risk or severity of edema formation can be increased when Testosterone enantate benzilic acid hydrazone is combined with Budesonide.
Clobetasol propionateThe risk or severity of edema formation can be increased when Testosterone enantate benzilic acid hydrazone is combined with Clobetasol propionate.
DesoximetasoneThe risk or severity of edema formation can be increased when Testosterone enantate benzilic acid hydrazone is combined with Desoximetasone.
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
34995240
Wikipedia
Testosterone_enantate_benzilic_acid_hydrazone

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
LiquidIntramuscular
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000122 mg/mLALOGPS
logP6.54ALOGPS
logP8.49ChemAxon
logS-6.7ALOGPS
pKa (Strongest Acidic)11.09ChemAxon
pKa (Strongest Basic)2.14ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area87.99 Å2ChemAxon
Rotatable Bond Count11ChemAxon
Refractivity182.37 m3·mol-1ChemAxon
Polarizability74.51 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as steroid esters. These are compounds containing a steroid moiety which bears a carboxylic acid ester group.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Steroid esters
Direct Parent
Steroid esters
Alternative Parents
Androstane steroids / Delta-4-steroids / Diphenylmethanes / Phenylacetamides / Tertiary alcohols / Carboxylic acid esters / Monocarboxylic acids and derivatives / Organonitrogen compounds / Organic oxides / Hydrocarbon derivatives
show 2 more
Substituents
Steroid ester / Androstane-skeleton / Delta-4-steroid / Diphenylmethane / Phenylacetamide / Monocyclic benzene moiety / Benzenoid / Tertiary alcohol / Carboxylic acid ester / Carboxylic acid derivative
show 11 more
Molecular Framework
Aromatic homopolycyclic compounds
External Descriptors
Not Available

Drug created on January 11, 2018 16:14 / Updated on October 01, 2018 15:40