Identification
- Summary
Strontium chloride is a medication used to treat bone pain in skeletal metastases.
- Generic Name
- Strontium chloride
- DrugBank Accession Number
- DB13987
- Background
Strontium chloride (SrCl2) is a salt of strontium and chloride. SrCl2 is useful in reducing tooth sensitivity by forming a barrier over microscopic tubules in the dentin containing nerve endings that have become exposed by gum recession 1,2. This kind of barrier protection for tooth hypersensitivity has, however, been superseded by other toothpaste formulations and ingredients designed to be nerve calming agents instead 1,2. Such strontium chloride toothpaste formulations may subsequently not be available for sale anymore in certain parts of the world 1,2.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Strontium chloride (DB13987)
- Weight
- Average: 158.52
Monoisotopic: 157.843318 - Chemical Formula
- Cl2Sr
- Synonyms
- strontium dichloride
Pharmacology
- Indication
When employed as an ingredient in toothpaste formulations, strontium chloride is predominantly indicated for treating teeth hypersensitivity 1,2,3,8.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Treatment of Bone pain •••••••••••• •••••••••• •••••••••• ••••••• ••• ••••••••• •••••••• - Contraindications & Blackbox Warnings
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As an active ingredient in a toothpaste formulation, strontium chloride and the rest of the toothpaste product that it is incorporated into is designed to come into contact with and topically coat the teeth 1,2,3 that are being brushed and is not supposed to be swallowed. The regular use of the toothpaste maintains protection that strontium chloride provides against tooth sensitivity despite the normal everyday wear, tear, and cleaning of teeth.
- Mechanism of action
For dental hypersensitivity, strontium ions in strontium chloride toothpaste formulations appear to relieve pain and sensitivity by blocking fluid flow in dentinal tubules, which are essentially microscopic canals in the dentin 1,2,3. Regular use of such toothpastes maintains the strontium chloride barricading of the tubules despite normal everyday wear, tear, and washing of teeth.
- Absorption
About 30 percent of ingested strontium is absorbed into the blood through the gut 5. The amount of strontium absorbed tends to decrease with age and is higher (about 60 percent) in children in their first year of life 5. Once it is absorbed into the blood, most of it ends up in bone; with the remainder going to soft tissues or being excreted in urine, feces, and sweat 5. About 8 percent of ingested strontium remains in the body after 30 days, and this decreases to about 4 percent after 1 year 5.
- Volume of distribution
The distribution of absorbed strontium in the human body is similar to that of calcium, with about 99% of total amount in the body being distributed in the skeleton 8.
- Protein binding
A protein binding of 30-40% has been documented for strontium chloride 6.
- Metabolism
Strontium can bind to proteins and, based on its similarity to calcium, probably forms complexes with various inorganic anions, such as carbonate and phosphate, and carboxylic acids, such as citrate and lactate 8. Strontium can also interact with ligands that normally bind calcium, like hypoxyapatite, the main component of mineralized bone, and a variety of calcium-binding and calcium transport proteins that are important in the physiological disposition of calcium in cells, including Ca2+ adenosine triphosphatases, Na+Ca+ antiport], and Ca2+ channels 8.
- Route of elimination
Once strontium is absorbed into the blood, most of it ends up in bone; with the remainder going to soft tissues or being excreted in urine, feces, and sweat 5.
- Half-life
Readily accessible information about the half-life of strontium calcium used in toothpastes is not available.
- Clearance
Despite being the major route of excretion of absorbed strontium, urinary excretion of absorbed strontium is observed to be slow 8.
- Adverse Effects
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Overdosage with strontium chloride toothpaste formulations has not been reported.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbacavir Abacavir may decrease the excretion rate of Strontium chloride which could result in a higher serum level. Aceclofenac Aceclofenac may decrease the excretion rate of Strontium chloride which could result in a higher serum level. Acemetacin Acemetacin may decrease the excretion rate of Strontium chloride which could result in a higher serum level. Acetaminophen Acetaminophen may decrease the excretion rate of Strontium chloride which could result in a higher serum level. Acetazolamide Acetazolamide may increase the excretion rate of Strontium chloride which could result in a lower serum level and potentially a reduction in efficacy. - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Strontium chloride hexahydrate O09USB7Z44 10025-70-4 AMGRXJSJSONEEG-UHFFFAOYSA-L - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Lorvic Desensitizer Strontium chloride (3.96 %) + Sodium fluoride (0.42 %) Gel Dental Lorvic Corp 1969-12-31 2001-08-06 Canada 
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as alkaline earth metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a lanthanide.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Alkaline earth metal salts
- Sub Class
- Alkaline earth metal chlorides
- Direct Parent
- Alkaline earth metal chlorides
- Alternative Parents
- Inorganic chloride salts
- Substituents
- Alkaline earth metal chloride / Inorganic chloride salt / Inorganic salt
- Molecular Framework
- Not Available
- External Descriptors
- inorganic chloride, strontium salt (CHEBI:36383)
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- EKE8PS9J6Z
- CAS number
- 10476-85-4
- InChI Key
- AHBGXTDRMVNFER-UHFFFAOYSA-L
- InChI
- InChI=1S/2ClH.Sr/h2*1H;/q;;+2/p-2
- IUPAC Name
- strontium(2+) dichloride
- SMILES
- [Cl-].[Cl-].[Sr++]
References
- General References
- Karim BF, Gillam DG: The efficacy of strontium and potassium toothpastes in treating dentine hypersensitivity: a systematic review. Int J Dent. 2013;2013:573258. doi: 10.1155/2013/573258. Epub 2013 Apr 8. [Article]
- Bartold PM: Dentinal hypersensitivity: a review. Aust Dent J. 2006 Sep;51(3):212-8; quiz 276. [Article]
- Natural Medicines Comprehensive Database: Strontium Monograph [Link]
- Colgate: How Long Should You Brush Your Teeth For? [Link]
- Pennsylvania Department of Health: Strontium [Link]
- PubChem: Strontium Chloride [Link]
- INVIMA: Acta 13 (28 April 1999) [Link]
- INCHEM Strontium and strontium compounds Profile [File]
- External Links
- ChemSpider
- 55440
- 37175
- ChEMBL
- CHEMBL2219640
- Wikipedia
- Strontium_chloride
- MSDS
- Download (42.6 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Unknown Status Treatment Osteoarthritis (OA) / Pain 1 2 Completed Treatment Amputation Stumps / Pain 1 2, 3 Completed Treatment Dentin Sensitivity 1 Not Available Completed Basic Science Oocyte Fertilization 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Gel Dental Injection, powder, for solution Intravenous 37 MBq - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 51.8 mg/mL ALOGPS logP 0.84 ALOGPS logP -0.3 Chemaxon logS -0.49 ALOGPS pKa (Strongest Acidic) 3.09 Chemaxon Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 0 m3·mol-1 Chemaxon Polarizability 1.78 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at February 10, 2018 22:01 / Updated at April 20, 2024 01:07