Englitazone

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Englitazone
Accession Number
DB14035
Type
Small Molecule
Groups
Experimental
Description

Englitazone is a hypoglycemic agent.

Structure
Thumb
Synonyms
Not Available
External IDs
CP 68722
Product Ingredients
IngredientUNIICASInChI Key
Englitazone sodiumVA5755GIJ8109229-57-4JQWYNJRCVYGLMO-GPPXSFHXSA-M
Categories
UNII
ZQW5577C3O
CAS number
109229-58-5
Weight
Average: 353.44
Monoisotopic: 353.10856465
Chemical Formula
C20H19NO3S
InChI Key
MVDXXGIBARMXSA-PYUWXLGESA-N
InChI
InChI=1S/C20H19NO3S/c22-19-18(25-20(23)21-19)12-14-6-9-17-15(10-14)7-8-16(24-17)11-13-4-2-1-3-5-13/h1-6,9-10,16,18H,7-8,11-12H2,(H,21,22,23)/t16-,18?/m1/s1
IUPAC Name
5-{[(2R)-2-benzyl-3,4-dihydro-2H-1-benzopyran-6-yl]methyl}-1,3-thiazolidine-2,4-dione
SMILES
O=C1NC(=O)C(CC2=CC=C3O[C@@H](CC4=CC=CC=C4)CCC3=C2)S1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
2,4-thiazolidinedioneThe risk or severity of hypoglycemia can be increased when 2,4-thiazolidinedione is combined with Englitazone.
5-(2-methylpiperazine-1-sulfonyl)isoquinolineThe therapeutic efficacy of Englitazone can be increased when used in combination with 5-(2-methylpiperazine-1-sulfonyl)isoquinoline.
AcarboseThe risk or severity of hypoglycemia can be increased when Acarbose is combined with Englitazone.
AcetazolamideThe therapeutic efficacy of Englitazone can be increased when used in combination with Acetazolamide.
AcetohexamideThe risk or severity of hypoglycemia can be increased when Acetohexamide is combined with Englitazone.
Acetyl sulfisoxazoleThe therapeutic efficacy of Englitazone can be increased when used in combination with Acetyl sulfisoxazole.
Acetylsalicylic acidAcetylsalicylic acid may increase the hypoglycemic activities of Englitazone.
AgmatineThe risk or severity of hypoglycemia can be increased when Agmatine is combined with Englitazone.
AICA ribonucleotideThe risk or severity of hypoglycemia can be increased when AICA ribonucleotide is combined with Englitazone.
AlaproclateThe risk or severity of hypoglycemia can be increased when Alaproclate is combined with Englitazone.
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
5293364
ChEMBL
CHEMBL17669
Wikipedia
Englitazone

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00121 mg/mLALOGPS
logP3.72ALOGPS
logP4.35ChemAxon
logS-5.5ALOGPS
pKa (Strongest Acidic)6.61ChemAxon
pKa (Strongest Basic)-4.9ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area55.4 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity98.06 m3·mol-1ChemAxon
Polarizability37.55 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on May 17, 2018 12:10 / Updated on November 02, 2018 09:14