Valinomycin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Valinomycin
Accession Number
DB14057
Type
Small Molecule
Groups
Experimental
Description

A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies.

Synonyms
  • Potassium ionophore I
  • Valinomicin
External IDs
ANTIBIOTIC N-329 B / BRN 0078657
Categories
UNII
N561YS75MN
CAS number
2001-95-8
Weight
Not Available
Chemical Formula
C54H90N6O18
InChI Key
FCFNRCROJUBPLU-DNDCDFAISA-N
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Valinomycin.
AcetaminophenThe serum concentration of Valinomycin can be increased when it is combined with Acetaminophen.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Valinomycin.
AmiodaroneThe serum concentration of Valinomycin can be increased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Valinomycin.
AmlodipineThe serum concentration of Valinomycin can be increased when it is combined with Amlodipine.
AmsacrineThe serum concentration of Valinomycin can be increased when it is combined with Amsacrine.
Ascorbic acidThe serum concentration of Ascorbic acid can be increased when it is combined with Valinomycin.
AtenololValinomycin may decrease the excretion rate of Atenolol which could result in a higher serum level.
AzithromycinThe serum concentration of Valinomycin can be increased when it is combined with Azithromycin.
Food Interactions
Not Available

References

General References
  1. Pinkerton M, Steinrauf LK, Dawkins P: The molecular structure and some transport properties of valinomycin. Biochem Biophys Res Commun. 1969 May 22;35(4):512-8. [PubMed:5788506]
External Links
ChemSpider
21493802
ChEBI
28545
ChEMBL
CHEMBL223643
Wikipedia
Valinomycin

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Transporters

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Inhibitor
General Function
Transporter activity
Specific Function
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name
ABCB11
Uniprot ID
O95342
Uniprot Name
Bile salt export pump
Molecular Weight
146405.83 Da
References
  1. Wilson A. (2016). New horizons in predictive drug metabolism and pharmacokinetics. The Royal Society of Chemistry. [ISBN:978-1-84973-828-6]

Drug created on June 12, 2018 14:59 / Updated on August 26, 2018 02:07