This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Valinomycin
Accession Number
DB14057
Type
Small Molecule
Groups
Experimental
Description

A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies.

Synonyms
  • Potassium ionophore I
  • Valinomicin
External IDs
ANTIBIOTIC N-329 B / BRN 0078657
Categories
UNII
N561YS75MN
CAS number
2001-95-8
Weight
Not Available
Chemical Formula
C54H90N6O18
InChI Key
FCFNRCROJUBPLU-DNDCDFAISA-N
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe risk or severity of bleeding can be increased when Valinomycin is combined with (R)-warfarin.
(S)-WarfarinThe risk or severity of bleeding can be increased when Valinomycin is combined with (S)-Warfarin.
4-hydroxycoumarinThe risk or severity of bleeding can be increased when Valinomycin is combined with 4-hydroxycoumarin.
AbemaciclibThe serum concentration of Valinomycin can be increased when it is combined with Abemaciclib.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Valinomycin.
AcenocoumarolThe risk or severity of bleeding can be increased when Valinomycin is combined with Acenocoumarol.
AcetaminophenThe serum concentration of Valinomycin can be increased when it is combined with Acetaminophen.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Valinomycin.
Adenovirus type 7 vaccine liveThe therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Valinomycin.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Valinomycin.
Food Interactions
Not Available

References

General References
  1. Pinkerton M, Steinrauf LK, Dawkins P: The molecular structure and some transport properties of valinomycin. Biochem Biophys Res Commun. 1969 May 22;35(4):512-8. [PubMed:5788506]
External Links
ChemSpider
21493802
ChEBI
28545
ChEMBL
CHEMBL223643
Wikipedia
Valinomycin

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Transporters

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Inhibitor
General Function
Transporter activity
Specific Function
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name
ABCB11
Uniprot ID
O95342
Uniprot Name
Bile salt export pump
Molecular Weight
146405.83 Da
References
  1. Wilson A. (2016). New horizons in predictive drug metabolism and pharmacokinetics. The Royal Society of Chemistry. [ISBN:978-1-84973-828-6]

Drug created on June 12, 2018 14:59 / Updated on November 02, 2018 07:49