This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Basifungin
- DrugBank Accession Number
- DB14058
- Background
Basifungin, also known as aureuobacidin A, is a phosphorylceramide synthase inhibitor 3, 1.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Basifungin (DB14058)
- Weight
- Average: 1085.442
Monoisotopic: 1084.693641194 - Chemical Formula
- C60H92N8O10
- Synonyms
- Aureobasidin A
- Basifungin
- External IDs
- Antibiotic R106I
- LY 295337
- LY295337
- NK 204
- R106-1
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism AInositol phosphorylceramide synthase inhibitorYeast - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcenocoumarol The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Basifungin. Dicoumarol The therapeutic efficacy of Dicoumarol can be increased when used in combination with Basifungin. Fluindione The therapeutic efficacy of Fluindione can be increased when used in combination with Basifungin. Phenindione The therapeutic efficacy of Phenindione can be increased when used in combination with Basifungin. Phenprocoumon The therapeutic efficacy of Phenprocoumon can be increased when used in combination with Basifungin. - Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- VV0USO6I6U
- CAS number
- 127785-64-2
- InChI Key
- YHSKJPXGXIYLHB-OTNPUQRPSA-N
- InChI
- InChI=1S/C60H92N8O10/c1-17-39(12)51-55(72)63-47(36(6)7)53(70)61-44(32-41-25-20-18-21-26-41)56(73)65(14)46(33-42-27-22-19-23-28-42)58(75)68-30-24-29-45(68)52(69)64-48(40(13)35(4)5)59(76)66(15)49(37(8)9)54(71)62-43(31-34(2)3)57(74)67(16)50(38(10)11)60(77)78-51/h18-23,25-28,34-40,43-51H,17,24,29-33H2,1-16H3,(H,61,70)(H,62,71)(H,63,72)(H,64,69)/t39-,40-,43+,44+,45+,46+,47?,48-,49+,50+,51+/m1/s1
- IUPAC Name
- (3R,6S,9S,12S,15S,21S,24S,29aS)-21,24-dibenzyl-15-[(2R)-butan-2-yl]-5,11,23-trimethyl-3-[(2R)-3-methylbutan-2-yl]-9-(2-methylpropyl)-6,12,18-tris(propan-2-yl)-octacosahydropyrrolo[1,2-m]1-oxa-4,7,10,13,16,19,22,25-octaazacycloheptacosane-1,4,7,10,13,16,19,22,25-nonone
- SMILES
- CC[C@@H](C)[C@@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC2=CC=CC=C2)N(C)C(=O)[C@H](CC2=CC=CC=C2)NC(=O)C(NC1=O)C(C)C)[C@H](C)C(C)C
References
- General References
- External Links
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00395 mg/mL ALOGPS logP 5.14 ALOGPS logP 7.02 Chemaxon logS -5.4 ALOGPS pKa (Strongest Acidic) 11.76 Chemaxon pKa (Strongest Basic) -2.3 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 9 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 223.94 Å2 Chemaxon Rotatable Bond Count 13 Chemaxon Refractivity 297.75 m3·mol-1 Chemaxon Polarizability 118 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Targets
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- Kind
- Protein
- Organism
- Yeast
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis.
- Specific Function
- Inositol phosphoceramide synthase activity
- Gene Name
- AUR1
- Uniprot ID
- O13332
- Uniprot Name
- Inositol phosphorylceramide synthase
- Molecular Weight
- 53457.9 Da
References
- Aeed PA, Young CL, Nagiec MM, Elhammer AP: Inhibition of inositol phosphorylceramide synthase by the cyclic peptide aureobasidin A. Antimicrob Agents Chemother. 2009 Feb;53(2):496-504. doi: 10.1128/AAC.00633-08. Epub 2008 Dec 1. [Article]
- aureobasidin A ( Basifungin) [Link]
- Basifungin PubChem [Link]
Drug created at June 14, 2018 19:28 / Updated at February 21, 2021 18:54