Cobalamin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Cobalamin
Accession Number
DB14098
Type
Small Molecule
Groups
Experimental
Description
Not Available
Structure
Thumb
Synonyms
Not Available
Product Images
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
DialyviteCobalamin (6 ug/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1)Tablet, coatedOralCarilion Materials Management1988-08-01Not applicableUs
DialyviteCobalamin (6 ug/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1)Tablet, coatedOralAtlantic Biologicals Corps.1988-08-01Not applicableUs
DialyviteCobalamin (6 ug/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1)Tablet, coatedOralHillestad Pharmaceuticals Usa1988-08-01Not applicableUs
Dialyvite 3000Cobalamin (1 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc citrate (15 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2004-02-01Not applicableUs
Dialyvite 5000Cobalamin (2 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (5 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc citrate (25 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2008-05-01Not applicableUs
Dialyvite Supreme DCobalamin (1 mg/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Cholecalciferol (2000 [iU]/1) + Folic acid (3 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (1.7 mg/1) + Selenocysteine (70 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc citrate (15 mg/1) + alpha-Tocopherol succinate (30 [iU]/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2010-09-08Not applicableUs
Dialyvite with ZincCobalamin (6 ug/1) + Ascorbic acid (100 mg/1) + Biotin (300 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc citrate (50 mg/1)Tablet, coatedOralHillestad Pharmaceuticals Usa2002-10-01Not applicableUs10542 01220180618 22549 l4id3e
Multivitamin with fluorideCobalamin (4.5 ug/1) + Ascorbic acid (60 mg/1) + Folic acid (0.3 mg/1) + Niacin (13.5 mg/1) + Pyridoxine (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.25 mg/1) + Thiamine chloride (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1) + Vitamin D (400 [iU]/1) + Vitamin E (15 [iU]/1)Tablet, chewableOralSancilio & Company, Inc.2011-12-202011-12-07Us
Multivitamin with fluorideCobalamin (4.5 ug/1) + Ascorbic acid (60 mg/1) + Folic acid (0.3 mg/1) + Niacin (13.5 mg/1) + Pyridoxine (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.5 mg/1) + Thiamine chloride (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1) + Vitamin D (400 [iU]/1) + Vitamin E (15 [iU]/1)Tablet, chewableOralSancilio & Company, Inc.2011-12-202011-12-07Us
Multivitamin with fluorideCobalamin (4.5 ug/1) + Ascorbic acid (60 mg/1) + Fluoride ion (1 mg/1) + Folic acid (0.3 mg/1) + Niacin (13.5 mg/1) + Pyridoxine (1.05 mg/1) + Riboflavin (1.2 mg/1) + Thiamine chloride (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1) + Vitamin D (400 [iU]/1) + Vitamin E (15 [iU]/1)Tablet, chewableOralSancilio & Company, Inc.2011-12-202011-12-07Us
Categories
UNII
8406EY2OQA
CAS number
13408-78-1
Weight
Average: 1329.37
Monoisotopic: 1328.564326
Chemical Formula
C62H88CoN13O14P
InChI Key
ASARMUCNOOHMLO-WLORSUFZSA-L
InChI
InChI=1S/C62H90N13O14P.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);/q;+2/p-2/t31-,34+,35+,36+,37-,41+,52+,53+,56+,57-,59+,60-,61-,62-;/m0./s1
IUPAC Name
lambda2-cobalt(2+) (1R,2R,3S,4S,6Z,8S,9S,11Z,14S,16Z,18R,19R)-4,9,14-tris(2-carbamoylethyl)-3,8,19-tris(carbamoylmethyl)-18-(2-{[(2S)-2-{[(2R,3S,4R,5S)-5-(5,6-dimethyl-1H-1,3-benzodiazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl phosphono]oxy}propyl]carbamoyl}ethyl)-2,3,6,8,13,13,16,18-octamethyl-20,21,22,23-tetraazapentacyclo[15.2.1.1^{2,5}.1^{7,10}.1^{12,15}]tricosa-5(23),6,10(22),11,15(21),16-hexaen-20-ide
SMILES
[Co++].[H]N([H])C(=O)CC[C@@H]1C2=N\C(=C(C)/C3=N[C@@](C)([C@]4([H])[N-]\C(=C(C)/C5=N/C(=C\2)/C(C)(C)[C@@H]5CCC(=O)N([H])[H])[C@](C)(CCC(=O)N([H])C[C@H](C)OP([O-])(=O)O[C@@H]2[C@@H](CO)O[C@@H]([C@@H]2O)N2C=NC5=C2C=C(C)C(C)=C5)[C@H]4CC(=O)N([H])[H])[C@@](C)(CC(=O)N([H])[H])[C@@H]3CCC(=O)N([H])[H])\[C@@]1(C)CC(=O)N([H])[H]

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
34987587
Wikipedia
Cobalamin

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentDiabetic Neuropathies / Polyneuropathies1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Tablet, chewableOral
Kit
Tablet, coatedOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0127 mg/mLALOGPS
logP2.63ALOGPS
logP-2.7ChemAxon
logS-5ALOGPS
pKa (Strongest Acidic)1.82ChemAxon
pKa (Strongest Basic)8.97ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count17ChemAxon
Hydrogen Donor Count9ChemAxon
Polar Surface Area460.05 Å2ChemAxon
Rotatable Bond Count26ChemAxon
Refractivity330.72 m3·mol-1ChemAxon
Polarizability132.57 Å3ChemAxon
Number of Rings8ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on June 18, 2018 12:53 / Updated on May 01, 2019 11:57