1,2-Distearoyllecithin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
1,2-Distearoyllecithin
Accession Number
DB14099
Type
Small Molecule
Groups
Approved, Experimental
Description
Not Available
Structure
Thumb
Synonyms
  • 1,2-Distearoyl-sn-glycero-3-phosphocholine
  • 1,2-Distearoylphosphatidylcholine
  • Dioctadecanoyl phosphatidylcholine
  • Dioctadecanoyllecithin
  • Distearoyl-DL-phosphatidylcholine
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
LumaSon1,2-Distearoyllecithin (.19 mg/1mg) + Sodium 1,2-Dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (.19 mg/1mg) + Sulfur hexafluoride (60.7 mg/1mg)KitIntravenous; IntravesicalBracco Diagnostics Inc2015-01-15Not applicableUs
LumaSon1,2-Distearoyllecithin (.19 mg/1mg) + Sodium 1,2-Dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (.19 mg/1mg) + Sulfur hexafluoride (60.7 mg/1mg)KitIntravenous; IntravesicalBracco Suisse SA2015-01-15Not applicableUs
Categories
UNII
EAG959U971
CAS number
4539-70-2
Weight
Average: 790.161
Monoisotopic: 789.624755796
Chemical Formula
C44H88NO8P
InChI Key
NRJAVPSFFCBXDT-UHFFFAOYSA-N
InChI
InChI=1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3
IUPAC Name
(2-{[2,3-bis(octadecanoyloxy)propyl phosphonato]oxy}ethyl)trimethylazanium
SMILES
CCCCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
58655
ChEMBL
CHEMBL113644

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedDevice FeasibilityStroke, Acute1
0Enrolling by InvitationDiagnosticProliferative Breast Disease1
0RecruitingDiagnosticDevelopmental Dysplasia of the Hip (DDH)1
0RecruitingScreeningDiseases of Liver / Hepatocellular,Carcinoma / Liver Cirrhosis1
1Not Yet RecruitingDiagnosticAppendicitis Acute1
1Not Yet RecruitingDiagnosticVesico-Ureteral Reflux1
1RecruitingBasic ScienceAtherosclerosis of Artery / Fibromuscular Dysplasia of Arteries / Segmental Arterial Mediolysis / Spontaneous Coronary Artery Dissection1
1RecruitingDiagnosticTransplantation, Kidney1
1, 2RecruitingDiagnosticAbdominal Injuries1
2CompletedDiagnosticUrinary Tract Infection / Vesicoureteral Reflux1
2RecruitingBasic ScienceCarotid Artery Plaque1
2RecruitingDiagnosticAppendicitis Acute1
2RecruitingDiagnosticChronic Kidney Disease (CKD) / Von-Hippel Lindau1
3CompletedDiagnosticCoronary Artery Disease2
3TerminatedDiagnosticCongenital Heart Disease (CHD)1
4Enrolling by InvitationDiagnosticCrohn's Disease (CD)1
4Not Yet RecruitingDiagnosticBone Marrow Transplant Complications / Sinusoidal Obstruction Syndrome / Stem Cell Transplant Complications / Veno Occlusive Disease, Hepatic1
4Not Yet RecruitingDiagnosticRenal Cancers1
4Not Yet RecruitingDiagnosticRenal Malignant Tumor1
4RecruitingDiagnosticAbdominal Injuries / Accidental Fall / Motor Vehicle Injury / Physical Abuse1
4RecruitingDiagnosticTrauma Abdomen1
4TerminatedDiagnosticLiver Biopsy1
4WithdrawnDiagnosticNeonatal Post-Hemorrhagic Hydrocephalus1
Not AvailableRecruitingNot AvailableCrohn's Disease (CD)1
Not AvailableRecruitingNot AvailableHematoma1
Not AvailableWithdrawnDiagnosticHepatocellular,Carcinoma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
KitIntravenous; Intravesical
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5686060No1997-11-112017-11-11Us
US10232061No2018-07-062038-07-06Us
US10335502No2018-07-062038-07-06Us
Additional Data Available
  • Filed On
    Filed On

    The date on which a patent was filed with the relevant government.

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Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility2.16e-05 mg/mLALOGPS
logP5.92ALOGPS
logP9.89ChemAxon
logS-7.6ALOGPS
pKa (Strongest Acidic)1.86ChemAxon
pKa (Strongest Basic)-6.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area111.19 Å2ChemAxon
Rotatable Bond Count44ChemAxon
Refractivity234.27 m3·mol-1ChemAxon
Polarizability98.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on June 18, 2018 12:57 / Updated on December 02, 2019 10:10