DL-alpha-Tocopherol
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Brand Names
- Citranatal Harmony
- Generic Name
- DL-alpha-Tocopherol
- DrugBank Accession Number
- DB14476
- Background
Not Available
- Type
- Small Molecule
- Groups
- Approved, Experimental, Investigational
- Structure
- Weight
- Average: 430.717
Monoisotopic: 430.38108085 - Chemical Formula
- C29H50O2
- Synonyms
- (+)-alpha-tocopherol
- (±)-α-tocopherol
- all-rac-alpha-tocopherol
- DL-5,7,8-trimethyltocol
- DL-alpha tocopherol
- DL-α-tocopherol
- Vitamin E DL-alpha
- External IDs
- E-307C
- Ins no.307C
- INS-307C
Pharmacology
- Indication
Not Available
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to prevent Vitamin deficiency •••••••••••• ••••••••• - Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareOrlistat Orlistat can cause a decrease in the absorption of DL-alpha-Tocopherol resulting in a reduced serum concentration and potentially a decrease in efficacy. - Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Advanced E With Non-medicinal Grape Seed Extract Capsule 400 unit / cap Oral Vita Health Products Inc 2000-03-01 2002-07-30 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Antiphlamine Coin Plaster DL-alpha-Tocopherol (0.308 mg/0.2832g) + Diphenhydramine (0.246 mg/0.2832g) + Levomenthol (2.769 mg/0.2832g) + Methyl salicylate (5.541 mg/0.2832g) + Nonivamide (0.046 mg/0.2832g) + Peppermint oil (0.693 mg/0.2832g) + Synthetic camphor (1.108 mg/0.2832g) Patch Topical Hanul Trading Co., Ltd. 2016-10-10 Not applicable US Arepanrix H5n1 DL-alpha-Tocopherol (11.86 mg / 0.5 mL) + Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated) (3.75 mcg / 0.5 mL) + Polysorbate 80 (4.86 mg / 0.5 mL) + Squalene (10.69 mg / 0.5 mL) Emulsion Intramuscular ID Biomedical Corporation of Quebec Not applicable Not applicable Canada CERNEVIT FOR INJECTION DL-alpha-Tocopherol (11.2 iu/vial) + Ascorbic acid (125 mg) + Biotin (0.069 mg) + Cholecalciferol (220 iu) + Cocarboxylase tetrahydrate (3.51 mg) + Cyanocobalamin (0.006 mg) + Dexpanthenol (17.25 mg/vial) + Folic acid (0.414 mg/vial) + Nicotinamide (46 mg/vial) + Pyridoxine hydrochloride (4.53 mg/vial) + Riboflavin (4.14 mg/vial) + Vitamin A palmitate (3500 iu/vial) Injection, powder, for solution Intravenous BAXTER HEALTHCARE (ASIA) PTE LTD 2002-05-06 Not applicable Singapore Eden With Vitamins A, C, and E DL-alpha-Tocopherol (1.8 unit / tab) + Ascorbic acid (10 mg / tab) + Beta carotene (0.8 mg / tab) Tablet Oral Warner Lambert Canada Inc. Not applicable Not applicable Canada P.N. Vitamin-mineral Drink DL-alpha-Tocopherol (30 unit / 30 mL) + Ascorbic acid (60 mg / 30 mL) + Beta carotene (5550 unit / 30 mL) + Biotin (300 mcg / 30 mL) + Cyanocobalamin (6 mcg / 30 mL) + Folic acid (0.4 mg / 30 mL) + Iron (6 mg / 30 mL) + Nicotinamide (20 mg / 30 mL) + Calcium pantothenate (10 mg / 30 mL) + Pyridoxine hydrochloride (2 mg / 30 mL) + Riboflavin (1.7 mg / 30 mL) + Thiamine (1.5 mg / 30 mL) + Vitamin A palmitate (3150 unit / 30 mL) + Vitamin D (400 unit / 30 mL) Liquid Oral Changes International Not applicable Not applicable Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Antiphlamine Coin Plaster DL-alpha-Tocopherol (0.308 mg/0.2832g) + Diphenhydramine (0.246 mg/0.2832g) + Levomenthol (2.769 mg/0.2832g) + Methyl salicylate (5.541 mg/0.2832g) + Nonivamide (0.046 mg/0.2832g) + Peppermint oil (0.693 mg/0.2832g) + Synthetic camphor (1.108 mg/0.2832g) Patch Topical Hanul Trading Co., Ltd. 2016-10-10 Not applicable US CitraNatal Harmony DL-alpha-Tocopherol (30 [iU]/1) + Calcium citrate tetrahydrate (100 mg/1) + Cholecalciferol (400 [iU]/1) + Doconexent (250 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (27 mg/1) + Pyridoxine hydrochloride (25 mg/1) Capsule, gelatin coated Oral Mission Pharmacal 2010-04-27 Not applicable US CitraNatal Harmony DL-alpha-Tocopherol (30 [iU]/1) + Calcium citrate tetrahydrate (100 mg/1) + Cholecalciferol (400 [iU]/1) + Doconexent (250 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (28 mg/1) + Pyridoxine hydrochloride (25 mg/1) Capsule, gelatin coated Oral Mission Pharmacal 2011-04-18 Not applicable US CitraNatal Harmony DL-alpha-Tocopherol (30 [iU]/1) + Calcium citrate tetrahydrate (104 mg/1) + Cholecalciferol (400 [iU]/1) + Doconexent (260 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (30 mg/1) + Pyridoxine hydrochloride (25 mg/1) Capsule, gelatin coated Oral Mission Pharmacal 2012-01-15 Not applicable US Escavite D DL-alpha-Tocopherol (30 [iU]/1) + Ascorbic acid (100 mg/1) + Beta carotene (2500 [iU]/1) + Biotin (45 ug/1) + Cholecalciferol (600 [iU]/1) + Cupric oxide (2 mg/1) + Ferrous cysteine glycinate (6 mg/1) + Folic acid (400 ug/1) + Hydroxocobalamin (6 ug/1) + Magnesium oxide (60 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (2 mg/1) + Riboflavin (1.7 mg/1) + Sodium fluoride (0.25 mg/1) + Thiamine hydrochloride (1.5 mg/1) + Zinc oxide (15 mg/1) Tablet, chewable Oral GM Pharmaceuticals, INC 2014-03-03 2018-11-01 US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as tocopherols. These are vitamin E derivatives containing a saturated trimethyltridecyl chain attached to the carbon C6 atom of a benzopyran ring system. The differ from tocotrienols that contain an unsaturated trimethyltrideca-3,7,11-trien-1-yl chain.
- Kingdom
- Organic compounds
- Super Class
- Lipids and lipid-like molecules
- Class
- Prenol lipids
- Sub Class
- Quinone and hydroquinone lipids
- Direct Parent
- Tocopherols
- Alternative Parents
- Diterpenoids / 1-benzopyrans / Alkyl aryl ethers / Benzenoids / Oxacyclic compounds / Hydrocarbon derivatives
- Substituents
- 1-benzopyran / Alkyl aryl ether / Aromatic heteropolycyclic compound / Benzenoid / Benzopyran / Chromane / Diterpenoid / Ether / Hydrocarbon derivative / Organic oxygen compound
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- vitamin E (ALPHA-TOCOPHEROL)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 7QWA1RIO01
- CAS number
- 10191-41-0
- InChI Key
- GVJHHUAWPYXKBD-UHFFFAOYSA-N
- InChI
- InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
- IUPAC Name
- 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol
- SMILES
- CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(O)=C(C)C(C)=C2O1
References
- General References
- Not Available
- External Links
- ChemSpider
- 2032
- BindingDB
- 50436220
- 220893
- ChEBI
- 93909
- ChEMBL
- CHEMBL49563
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Treatment Alzheimer's Disease (AD) 1 2 Withdrawn Treatment Hyperinsulinism-Hyperammonemia Syndrome 1 2, 3 Completed Prevention Atherosclerosis 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Oral 400 unit / cap Patch Topical Emulsion Intramuscular Injection, powder, for solution Intravenous Capsule, gelatin coated Oral Tablet Oral Capsule Oral Injection, emulsion Intravenous Liquid Oral Tablet, coated Oral Tablet, chewable Oral Powder Oral Injection, solution, concentrate Intravenous Emulsion Intravenous - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 7.04e-06 mg/mL ALOGPS logP 8.84 ALOGPS logP 10.51 Chemaxon logS -7.8 ALOGPS pKa (Strongest Acidic) 10.8 Chemaxon pKa (Strongest Basic) -4.9 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 29.46 Å2 Chemaxon Rotatable Bond Count 12 Chemaxon Refractivity 135.37 m3·mol-1 Chemaxon Polarizability 56.18 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-001i-8293800000-a57e127653bbb81ba41a Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-004i-0000900000-bd7ecb9ebd699f4b6394 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-01t9-0902400000-ada5eecb1a4dff613657 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0595-9213000000-cbf40775378f662c2900 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0292-0795300000-0cf018c231918c65a1ca Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-053r-9230000000-cb63548d7ebd18fd48a8 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 216.56212 predictedDeepCCS 1.0 (2019) [M+H]+ 220.22978 predictedDeepCCS 1.0 (2019) [M+Na]+ 229.04488 predictedDeepCCS 1.0 (2019)
Drug created at July 06, 2018 18:47 / Updated at April 17, 2024 06:33