DL-alpha-Tocopherol

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
DL-alpha-Tocopherol
Accession Number
DB14476
Type
Small Molecule
Groups
Approved, Experimental, Investigational
Description
Not Available
Structure
Thumb
Synonyms
  • (+)-alpha-tocopherol
  • (±)-α-tocopherol
  • all-rac-alpha-tocopherol
  • DL-5,7,8-trimethyltocol
  • DL-alpha tocopherol
  • DL-α-tocopherol
  • Vitamin E DL-alpha
External IDs
E-307C / Ins no.307C / INS-307C
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Advanced E With Non-medicinal Grape Seed ExtractCapsule400 unitOralVita Health Products Inc2000-03-012002-07-30Canada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Antiphlamine Coin PlasterDL-alpha-Tocopherol (0.308 mg/0.2832g) + Diphenhydramine (0.246 mg/0.2832g) + Levomenthol (2.769 mg/0.2832g) + Methyl salicylate (5.541 mg/0.2832g) + Nonivamide (0.046 mg/0.2832g) + Peppermint oil (0.693 mg/0.2832g) + Synthetic camphor (1.108 mg/0.2832g)PatchTopicalHanul Trading Co., Ltd.2016-10-10Not applicableUs
Eden With Vitamins A, C, and EDL-alpha-Tocopherol (1.8 unit) + Ascorbic acid (10 mg) + Beta carotene (0.8 mg)TabletOralWarner Lambert Canada Inc.Not applicableNot applicableCanada
P.N. Vitamin-mineral DrinkDL-alpha-Tocopherol (30 unit) + Ascorbic acid (60 mg) + Beta carotene (5550 unit) + Biotin (300 mcg) + Cyanocobalamin (6 mcg) + Folic acid (0.4 mg) + Iron (6 mg) + Nicotinamide (20 mg) + Calcium pantothenate (10 mg) + Pyridoxine hydrochloride (2 mg) + Riboflavin (1.7 mg) + Thiamine (1.5 mg) + Vitamin A palmitate (3150 unit) + Vitamin D (400 unit)LiquidOralChanges InternationalNot applicableNot applicableCanada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Antiphlamine Coin PlasterDL-alpha-Tocopherol (0.308 mg/0.2832g) + Diphenhydramine (0.246 mg/0.2832g) + Levomenthol (2.769 mg/0.2832g) + Methyl salicylate (5.541 mg/0.2832g) + Nonivamide (0.046 mg/0.2832g) + Peppermint oil (0.693 mg/0.2832g) + Synthetic camphor (1.108 mg/0.2832g)PatchTopicalHanul Trading Co., Ltd.2016-10-10Not applicableUs
CitraNatal HarmonyDL-alpha-Tocopherol (30 [iU]/1) + Calcium citrate tetrahydrate (104 mg/1) + Cholecalciferol (400 [iU]/1) + Doconexent (260 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (30 mg/1) + Pyridoxine hydrochloride (25 mg/1)Capsule, gelatin coatedOralMission Pharmacal2012-01-15Not applicableUs
CitraNatal HarmonyDL-alpha-Tocopherol (30 [iU]/1) + Calcium citrate tetrahydrate (100 mg/1) + Cholecalciferol (400 [iU]/1) + Doconexent (250 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (27 mg/1) + Pyridoxine hydrochloride (25 mg/1)Capsule, gelatin coatedOralMission Pharmacal2010-04-27Not applicableUs
CitraNatal HarmonyDL-alpha-Tocopherol (30 [iU]/1) + Calcium citrate tetrahydrate (100 mg/1) + Cholecalciferol (400 [iU]/1) + Doconexent (250 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (28 mg/1) + Pyridoxine hydrochloride (25 mg/1)Capsule, gelatin coatedOralMission Pharmacal2011-04-18Not applicableUs
Escavite DDL-alpha-Tocopherol (30 [iU]/1) + Ascorbic acid (100 mg/1) + Beta carotene (2500 [iU]/1) + Biotin (45 ug/1) + Cholecalciferol (600 [iU]/1) + Cupric oxide (2 mg/1) + Ferrous cysteine glycinate (6 mg/1) + Folic acid (400 ug/1) + Hydroxocobalamin (6 ug/1) + Magnesium oxide (60 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (2 mg/1) + Riboflavin (1.7 mg/1) + Sodium fluoride (0.25 mg/1) + Thiamine hydrochloride (1.5 mg/1) + Zinc oxide (15 mg/1)Tablet, chewableOralGm Pharmaceuticals2014-03-03Not applicableUs
Prenate DHADL-alpha-Tocopherol (40 [iU]/1) + Ascorbic acid (90 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (25 ug/1) + Doconexent (300 mg/1) + Ferrous asparto glycinate (18 mg/1) + Folic acid (1 mg/1) + Calcium formate (155 mg/1) + Magnesium oxide (50 mg/1) + Pyridoxine hydrochloride (26 mg/1)Capsule, gelatin coatedOralAvion Pharmaceuticals, Llc2014-06-05Not applicableUs
Prenate DHADL-alpha-Tocopherol (10 [iU]/1) + Ascorbic acid (90 mg/1) + Calcium Carbonate (145 mg/1) + Cholecalciferol (220 [iU]/1) + Cyanocobalamin (13 ug/1) + Doconexent (300 mg/1) + Ferrous fumarate (28 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (50 mg/1) + Pyridoxine hydrochloride (26 mg/1)Capsule, gelatin coatedOralAvion Pharmaceuticals, Llc2012-01-312016-04-30Us
Prenate EssentialDL-alpha-Tocopherol (10 [iU]/1) + Ascorbic acid (90 mg/1) + Biotin (280 ug/1) + Calcium Carbonate (145 mg/1) + Cholecalciferol (220 [iU]/1) + Cyanocobalamin (13 ug/1) + Doconexent (300 mg/1) + Ferrous fumarate (29 mg/1) + Folic acid (1 mg/1) + Icosapent (40 mg/1) + Magnesium oxide (50 mg/1) + Potassium Iodide (150 ug/1) + Pyridoxine hydrochloride (26 mg/1)Tablet, coatedOralAvion Pharmaceuticals, Llc2012-11-122015-09-30Us
Prenate MiniDL-alpha-Tocopherol (10 [iU]/1) + Ascorbic acid (60 mg/1) + Biotin (280 ug/1) + Calcium Carbonate (100 mg/1) + Cholecalciferol (220 [iU]/1) + Cyanocobalamin (13 ug/1) + Doconexent (350 mg/1) + Folic acid (1 mg/1) + Iron (29 mg/1) + Lowbush blueberry (25 mg/1) + Magnesium oxide (25 mg/1) + Potassium Iodide (150 ug/1) + Pyridoxine hydrochloride (26 mg/1)Capsule, gelatin coatedOralAvion Pharmaceuticals, Llc2012-05-152016-09-30Us
Quflora PediatricDL-alpha-Tocopherol (15 [iU]/1) + Ascorbic acid (60 mg/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (1 mg/1) + Cyanocobalamin (4 ug/1) + Folic acid (100 ug/1) + Levomefolic acid (108 ug/1) + Magnesium oxide (15 mg/1) + Nicotinamide (5 mg/1) + Pyridoxine hydrochloride (1.5 mg/1) + Riboflavin (1.3 mg/1) + Sodium fluoride (1 mg/1) + Thiamine hydrochloride (1.2 mg/1) + Vitamin A acetate (1200 [iU]/1)Tablet, chewableOralCarwin Associates, Inc2014-01-06Not applicableUs
Categories
UNII
7QWA1RIO01
CAS number
10191-41-0
Weight
Average: 430.717
Monoisotopic: 430.38108085
Chemical Formula
C29H50O2
InChI Key
GVJHHUAWPYXKBD-UHFFFAOYSA-N
InChI
InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
IUPAC Name
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol
SMILES
CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(O)=C(C)C(C)=C2O1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
2032
BindingDB
50436220
ChEBI
93909
ChEMBL
CHEMBL49563
AHFS Codes
  • 88:20.00 — Vitamin E

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2, 3CompletedPreventionAtherosclerosis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CapsuleOral400 unit
PatchTopical
Capsule, gelatin coatedOral
TabletOral
Tablet, chewableOral
CapsuleOral
LiquidOral
Tablet, coatedOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility7.04e-06 mg/mLALOGPS
logP8.84ALOGPS
logP10.51ChemAxon
logS-7.8ALOGPS
pKa (Strongest Acidic)10.8ChemAxon
pKa (Strongest Basic)-4.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area29.46 Å2ChemAxon
Rotatable Bond Count12ChemAxon
Refractivity135.37 m3·mol-1ChemAxon
Polarizability56.18 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-0742900000-e04f7b35db8df7846abb
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-014i-1910000000-cc361786eb3f51f45d19
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-066r-3930000000-979a3e4c33d64d0c6215
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-0110900000-d5b620320c97f00ad562
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-01t9-0730900000-36e33000e46f480ceb9d
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-03e9-0921200000-7c36ba360f71f0d4b512

Taxonomy

Classification
Not classified

Drug created on July 06, 2018 12:47 / Updated on July 18, 2019 19:08