Sodium ascorbate

Identification

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Name
Sodium ascorbate
Accession Number
DB14482  (DBSALT001764)
Type
Small Molecule
Groups
Approved, Nutraceutical
Description
Not Available
Structure
Thumb
Synonyms
  • Ascorbato sódico
  • Ascorbic acid sodium salt
  • L-Ascorbic acid sodium salt
  • L-Ascorbic acid, monosodium salt
  • Monosodium L-ascorbate
  • Sodium ascorbate
  • sodium L-ascorbate
  • Vitamin C sodium
  • Vitamin C, sodium salt
Active Moieties
NameKindUNIICASInChI Key
Ascorbic acidunknownPQ6CK8PD0R50-81-7CIWBSHSKHKDKBQ-JLAZNSOCSA-N
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Mega-C-sodium Inj 250mg/mlSolution250 mgIntravenousKripps Pharmacy Ltd.1981-12-31Not applicableCanada
Vitamin CLiquid250 mgIntramuscular; IntravenousSandoz Canada Incorporated1989-12-31Not applicableCanada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
C Wafer 500 Chewable 500mgWafer500 mgOralNu Life Nutrition Ltd.1986-12-312000-05-23Canada
Natural Fruit Chew C 250mg Tangy Orange FlavourTablet250 mgOralNatural Factors Nutritional Products Ltd.2001-01-012009-09-28Canada
Sodium Ascor Crystal 888.8mg/gm USPPowder888.8 mgOralVita Health Products Inc1996-10-112002-07-31Canada
Tgi Tab 50mgTablet50 mgOralSeroyal International Inc.1980-12-311996-09-10Canada
Vitamin C 60mgTablet60 mgOralWn Pharmaceuticals Ltd.1999-04-092008-07-17Canada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Animal Shaped Chew Vit C Tab 250mgSodium ascorbate (159 mg) + Ascorbic acid (110 mg)TabletOralHall Laboratories, Ltd.1982-12-312003-09-11Canada
AppedrineSodium ascorbate (10 mg) + Benzocaine (3 mg) + Ferrous fumarate (3.33 mg) + Nicotinamide (3.33 mg) + Riboflavin (.4 mg) + Thiamine hydrochloride (.33 mg) + Vitamin A (1333 unit) + Vitamin D (133 unit)TabletOralChattem, Inc.1975-12-312004-07-08Canada
Ascorbex 500 TabSodium ascorbate (337.5 mg) + Ascorbic acid (200 mg)TabletOralSantÉ Naturelle (Ag) LtÉe1988-12-312004-08-05Canada
Ascorbic Acid Tab 100mg Orange FlavorSodium ascorbate (56.2 mg) + Ascorbic acid (50 mg)TabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1969-12-311997-10-14Canada
Ascorbic Acid Tab 250mg Orange FlavorSodium ascorbate (168.75 mg) + Ascorbic acid (100 mg)TabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1969-12-311997-10-14Canada
Bugs Bunny and Friends Multiple VitaminsSodium ascorbate (50 mg) + Cyanocobalamin (3 mcg) + Folic acid (0.1 mg) + Nicotinamide (15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (1.5 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A (5000 unit) + Vitamin D (400 unit)TabletOralBayer Inc Consumer Care1996-12-312004-04-15Canada
Bugs Bunny Chew Multi Vit Plus IronSodium ascorbate (50 mg) + Cyanocobalamin (3 mcg) + Ferrous fumarate (12 mg) + Folic acid (.1 mg) + Nicotinamide (15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (1.5 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A acetate (5000 unit) + Vitamin D (400 unit)TabletOralMiles Inc. Pharmaceutical Division1983-12-311996-09-09Canada
Chewable Multiple Vitamins for ChildrenSodium ascorbate (50 mg) + Cyanocobalamin (3 mcg) + Folic acid (.1 mg) + Nicotinamide (15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (1.5 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A acetate (5000 unit) + Vitamin D (400 unit)TabletOralRandle Pharmaceutical Inc.1996-09-191999-09-03Canada
Chewable MultivitaminsSodium ascorbate (50 mg) + Cholecalciferol (400 unit) + Cyanocobalamin (3 mcg) + Folic acid (0.1 mg) + Nicotinamide (15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (1.5 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A (5000 unit)TabletOralWn Pharmaceuticals Ltd.2002-05-312008-07-17Canada
Chewable Multivitamins Plus IronSodium ascorbate (50 mg) + Cholecalciferol (400 unit) + Cyanocobalamin (3 mcg) + Ferrous fumarate (4 mg) + Folic acid (0.1 mg) + Nicotinamide (15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (1.5 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A (5000 unit)TabletOralWn Pharmaceuticals Ltd.2002-05-312007-08-07Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
CentratexSodium ascorbate (200 mg/1) + Cupric sulfate (0.8 mg/1) + Cyanocobalamin (15 ug/1) + Folic acid (1 mg/1) + Iron (106 mg/1) + Magnesium sulfate (6.9 mg/1) + Manganese sulfate (1.3 mg/1) + Nicotinamide (30 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (5 mg/1) + Riboflavin (6 mg/1) + Thiamine mononitrate (10 mg/1) + Zinc sulfate, unspecified form (18.2 mg/1)CapsuleOralCenturion Labs2009-06-14Not applicableUs
Irospan 24/6Sodium ascorbate (100 mg/1) + Sodium ascorbate (100 mg/1) + Biotin (300 ug/1) + Biotin (300 ug/1) + Calcium Carbonate (100 mg/1) + Cyanocobalamin (10 ug/1) + Cyanocobalamin (10 ug/1) + Ferrous bisglycinate (65 mg/1) + Folic acid (1 mg/1) + Folic acid (1 mg/1) + Calcium formate (155 mg/1) + Iron Dextran (65 mg/1) + Niacin (25 mg/1) + Niacin (25 mg/1) + Calcium pantothenate (300 ug/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Riboflavin sodium (5 mg/1) + Riboflavin (5 mg/1) + Succinic acid (150 mg/1) + Thiamine hydrochloride (5 mg/1) + Thiamine hydrochloride (5 mg/1)KitWOMENS CHOICE PHARMACEUTICALS LLC2011-04-15Not applicableUs
Irospan 24/6Sodium ascorbate (100 mg/1) + Sodium ascorbate (100 mg/1) + Biotin (300 ug/1) + Biotin (300 ug/1) + Calcium Carbonate (100 mg/1) + Cyanocobalamin (10 ug/1) + Cyanocobalamin (10 ug/1) + Ferrous bisglycinate (65 mg/1) + Folic acid (1 mg/1) + Folic acid (1 mg/1) + Calcium formate (155 mg/1) + Iron Dextran (65 mg/1) + Niacin (25 mg/1) + Niacin (25 mg/1) + Calcium pantothenate (300 ug/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Riboflavin sodium (5 mg/1) + Riboflavin (5 mg/1) + Succinic acid (150 mg/1) + Thiamine hydrochloride (5 mg/1) + Thiamine hydrochloride (5 mg/1)KitWOMENS CHOICE PHARMACEUTICALS LLC2011-04-15Not applicableUs
Multi Vitamin with FluorideSodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.5 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)Tablet, chewableOralQualitest2009-10-092014-12-31Us
Multi Vitamin with FluorideSodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (1 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)Tablet, chewableOralPhysicians Total Care, Inc.2003-06-042013-01-15Us
Multi Vitamin with FluorideSodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.25 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)Tablet, chewableOralQualitest2009-10-092014-08-31Us
Multi Vitamin with FluorideSodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.5 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)Tablet, chewableOralPhysicians Total Care, Inc.2003-09-082013-01-15Us
Multi Vitamin with FluorideSodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.25 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)Tablet, chewableOralPhysicians Total Care, Inc.2003-09-052013-01-15Us
Multi Vitamin with FluorideSodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.5 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)Tablet, chewableOralA S Medication Solutions2009-10-09Not applicableUs
Multi Vitamin with FluorideSodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (1 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)Tablet, chewableOralQualitest2009-10-092014-12-31Us
Categories
UNII
S033EH8359
CAS number
134-03-2
Weight
Average: 198.106
Monoisotopic: 198.01403223
Chemical Formula
C6H7NaO6
InChI Key
PPASLZSBLFJQEF-RXSVEWSESA-M
InChI
InChI=1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1
IUPAC Name
sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate
SMILES
[Na+].[H][C@@]1(OC(=O)C(O)=C1[O-])[C@@H](O)CO

Pharmacology

Indication
Not Available
Associated Therapies
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
2,5-Dimethoxy-4-ethylamphetamineThe serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when it is combined with Sodium ascorbate.
2,5-Dimethoxy-4-ethylthioamphetamineThe serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when it is combined with Sodium ascorbate.
4-Bromo-2,5-dimethoxyamphetamineThe serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when it is combined with Sodium ascorbate.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium ascorbate.
AclidiniumThe therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Aclidinium.
AgmatineThe therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Agmatine.
AlfentanilThe therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Alfentanil.
AlmasilateThe therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Almasilate.
AloglutamolThe therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Aloglutamol.
AlphacetylmethadolThe therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Alphacetylmethadol.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

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  • Evidence Level
    Evidence Level

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Food Interactions
Not Available

References

General References
Not Available
External Links
KEGG Drug
D05853
ChemSpider
16736174
ChEBI
113451
ChEMBL
CHEMBL591665
PharmGKB
PA166163262
Wikipedia
Sodium_ascorbate
AHFS Codes
  • 88:12.00 — Vitamin C

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Not Yet RecruitingPreventionOpen Posterior Thoracolumbar Spinal Fusion Procedure1
0RecruitingBasic ScienceArterial Stiffness / Vasodilation1
1, 2RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2WithdrawnTreatmentMalignant Neoplasm of Pancreas / Pancreatic Adenocarcinoma Resectable / Pancreatic Cancer Metastatic / Pancreatic Ductal Adenocarcinoma / Pancreatic Metastasis2
1, 2WithdrawnTreatmentPancreatic Cancer Metastatic1
2Not Yet RecruitingTreatmentNeoplasms, Pancreatic1
2RecruitingTreatmentAlcoholic Hepatitis (AH) / Sepsis1
2RecruitingTreatmentLeukemia, Lymphocytic / Lymphoma, Hodgkins / Monocytic Leukemia / Multiple Myeloma (MM) / Myelodysplasia / Myeloid Leukemias / Non Hodgkin Lymphoma (NHL)1
2RecruitingTreatmentMalignant Lymphomas / Myeloma Multiple1
2RecruitingTreatmentSepsis / Shock, Septic1
3Not Yet RecruitingPreventionAbdominal Hysterectomy1
3Not Yet RecruitingTreatmentShock, Septic1
3RecruitingTreatmentAnemias / Iron Deficiency Anemia (IDA)1
3RecruitingTreatmentIntensive Care Units / Sepsis / Vitamin c1
3RecruitingTreatmentSepsis / Shock, Septic1
4Active Not RecruitingDiagnosticColon Adenomas / Colon Lesion / Colon Polyps1
4RecruitingPreventionAging / Inflammatory Reaction1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
WaferOral500 mg
SolutionIntravenous250 mg
Powder, for solutionOral
Tablet, chewableOral
TabletOral250 mg
Tablet, film coatedOral
Kit
LiquidOral
PowderOral
Capsule, gelatin coatedOral
PowderOral888.8 mg
CapsuleOral
TabletOral50 mg
Tablet, coatedOral
LiquidIntramuscular; Intravenous250 mg
TabletOral60 mg
LozengeOral
TabletOral
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7169381No2007-01-302024-09-01Us
US7658914No2010-02-092024-09-01Us
US9326969No2016-05-032033-09-10Us
US9592252No2017-03-142032-08-11Us
US9707297No2017-07-182033-09-10Us
US8999313No2015-04-072033-09-10Us
US10016504No2018-07-102033-09-10Us
Additional Data Available
  • Filed On
    Filed On

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Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility625.0 mg/mLALOGPS
logP-1.4ALOGPS
logP-1.9ChemAxon
logS0.5ALOGPS
pKa (Strongest Acidic)4.36ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area110.05 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity47.58 m3·mol-1ChemAxon
Polarizability14.51 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as butenolides. These are dihydrofurans with a carbonyl group at the C2 carbon atom.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Dihydrofurans
Sub Class
Furanones
Direct Parent
Butenolides
Alternative Parents
Vinylogous acids / Enoate esters / Secondary alcohols / Lactones / 1,2-diols / Oxacyclic compounds / Monocarboxylic acids and derivatives / Primary alcohols / Organic zwitterions / Organic sodium salts
show 3 more
Substituents
2-furanone / Enoate ester / Alpha,beta-unsaturated carboxylic ester / Vinylogous acid / 1,2-diol / Carboxylic acid ester / Lactone / Secondary alcohol / Monocarboxylic acid or derivatives / Carboxylic acid derivative
show 13 more
Molecular Framework
Aliphatic heteromonocyclic compounds
External Descriptors
Not Available

Drug created on July 06, 2018 16:02 / Updated on July 16, 2019 06:23