Sodium ascorbate

Identification

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Name

Sodium ascorbate

Accession Number

DB14482  (DBSALT001764)

Type

Small Molecule

Groups

Approved, Nutraceutical

Description

Not Available

Structure

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MOLSDFPDBSMILESInChI

Similar Structures

Structure for Sodium ascorbate (DB14482)

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Synonyms

• Ascorbato sódico
• Ascorbic acid sodium salt
• L-Ascorbic acid sodium salt
• L-Ascorbic acid, monosodium salt
• Monosodium L-ascorbate
• Sodium ascorbate
• sodium L-ascorbate
• Vitamin C sodium
• Vitamin C, sodium salt

Active Moieties

Name	Kind	UNII	CAS	InChI Key
Ascorbic acid	unknown	PQ6CK8PD0R	50-81-7	CIWBSHSKHKDKBQ-JLAZNSOCSA-N
Sodium cation	ionic	LYR4M0NH37	17341-25-2	FKNQFGJONOIPTF-UHFFFAOYSA-N

Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
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Mega-C-sodium Inj 250mg/ml	Solution	250 mg	Intravenous	Kripps Pharmacy Ltd.	1981-12-31	Not applicable
Vitamin C	Liquid	250 mg	Intramuscular; Intravenous	Sandoz Canada Incorporated	1989-12-31	Not applicable

Additional Data Available

Application Number
Application Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
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Product Code
Product Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
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Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
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C Wafer 500 Chewable 500mg	Wafer	500 mg	Oral	Nu Life Nutrition Ltd.	1986-12-31	2000-05-23
Natural Fruit Chew C 250mg Tangy Orange Flavour	Tablet	250 mg	Oral	Natural Factors Nutritional Products Ltd.	2001-01-01	2009-09-28
Sodium Ascor Crystal 888.8mg/gm USP	Powder	888.8 mg	Oral	Vita Health Products Inc	1996-10-11	2002-07-31
Tgi Tab 50mg	Tablet	50 mg	Oral	Seroyal International Inc.	1980-12-31	1996-09-10
Vitamin C 60mg	Tablet	60 mg	Oral	Wn Pharmaceuticals Ltd.	1999-04-09	2008-07-17

Additional Data Available

Application Number
Application Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
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Product Code
Product Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
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Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Animal Shaped Chew Vit C Tab 250mg	Sodium ascorbate (159 mg) + Ascorbic acid (110 mg)	Tablet	Oral	Hall Laboratories, Ltd.	1982-12-31	2003-09-11
Appedrine	Sodium ascorbate (10 mg) + Benzocaine (3 mg) + Ferrous fumarate (3.33 mg) + Nicotinamide (3.33 mg) + Riboflavin (.4 mg) + Thiamine hydrochloride (.33 mg) + Vitamin A (1333 unit) + Vitamin D (133 unit)	Tablet	Oral	Chattem, Inc.	1975-12-31	2004-07-08
Ascorbex 500 Tab	Sodium ascorbate (337.5 mg) + Ascorbic acid (200 mg)	Tablet	Oral	SantÉ Naturelle (Ag) LtÉe	1988-12-31	2004-08-05
Ascorbic Acid Tab 100mg Orange Flavor	Sodium ascorbate (56.2 mg) + Ascorbic acid (50 mg)	Tablet	Oral	Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.	1969-12-31	1997-10-14
Ascorbic Acid Tab 250mg Orange Flavor	Sodium ascorbate (168.75 mg) + Ascorbic acid (100 mg)	Tablet	Oral	Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.	1969-12-31	1997-10-14
Bugs Bunny and Friends Multiple Vitamins	Sodium ascorbate (50 mg) + Cyanocobalamin (3 mcg) + Folic acid (0.1 mg) + Nicotinamide (15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (1.5 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A (5000 unit) + Vitamin D (400 unit)	Tablet	Oral	Bayer Inc Consumer Care	1996-12-31	2004-04-15
Bugs Bunny Chew Multi Vit Plus Iron	Sodium ascorbate (50 mg) + Cyanocobalamin (3 mcg) + Ferrous fumarate (12 mg) + Folic acid (.1 mg) + Nicotinamide (15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (1.5 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A acetate (5000 unit) + Vitamin D (400 unit)	Tablet	Oral	Miles Inc. Pharmaceutical Division	1983-12-31	1996-09-09
Chewable Multiple Vitamins for Children	Sodium ascorbate (50 mg) + Cyanocobalamin (3 mcg) + Folic acid (.1 mg) + Nicotinamide (15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (1.5 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A acetate (5000 unit) + Vitamin D (400 unit)	Tablet	Oral	Randle Pharmaceutical Inc.	1996-09-19	1999-09-03
Chewable Multivitamins	Sodium ascorbate (50 mg) + Cholecalciferol (400 unit) + Cyanocobalamin (3 mcg) + Folic acid (0.1 mg) + Nicotinamide (15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (1.5 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A (5000 unit)	Tablet	Oral	Wn Pharmaceuticals Ltd.	2002-05-31	2008-07-17
Chewable Multivitamins Plus Iron	Sodium ascorbate (50 mg) + Cholecalciferol (400 unit) + Cyanocobalamin (3 mcg) + Ferrous fumarate (4 mg) + Folic acid (0.1 mg) + Nicotinamide (15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (1.5 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A (5000 unit)	Tablet	Oral	Wn Pharmaceuticals Ltd.	2002-05-31	2007-08-07

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Centratex	Sodium ascorbate (200 mg/1) + Cupric sulfate (0.8 mg/1) + Cyanocobalamin (15 ug/1) + Folic acid (1 mg/1) + Iron (106 mg/1) + Magnesium sulfate (6.9 mg/1) + Manganese sulfate (1.3 mg/1) + Nicotinamide (30 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (5 mg/1) + Riboflavin (6 mg/1) + Thiamine mononitrate (10 mg/1) + Zinc sulfate, unspecified form (18.2 mg/1)	Capsule	Oral	Centurion Labs	2009-06-14	Not applicable
Irospan 24/6	Sodium ascorbate (100 mg/1) + Sodium ascorbate (100 mg/1) + Biotin (300 ug/1) + Biotin (300 ug/1) + Calcium Carbonate (100 mg/1) + Cyanocobalamin (10 ug/1) + Cyanocobalamin (10 ug/1) + Ferrous bisglycinate (65 mg/1) + Folic acid (1 mg/1) + Folic acid (1 mg/1) + Calcium formate (155 mg/1) + Iron Dextran (65 mg/1) + Niacin (25 mg/1) + Niacin (25 mg/1) + Calcium pantothenate (300 ug/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Riboflavin sodium (5 mg/1) + Riboflavin (5 mg/1) + Succinic acid (150 mg/1) + Thiamine hydrochloride (5 mg/1) + Thiamine hydrochloride (5 mg/1)	Kit		WOMENS CHOICE PHARMACEUTICALS LLC	2011-04-15	Not applicable
Irospan 24/6	Sodium ascorbate (100 mg/1) + Sodium ascorbate (100 mg/1) + Biotin (300 ug/1) + Biotin (300 ug/1) + Calcium Carbonate (100 mg/1) + Cyanocobalamin (10 ug/1) + Cyanocobalamin (10 ug/1) + Ferrous bisglycinate (65 mg/1) + Folic acid (1 mg/1) + Folic acid (1 mg/1) + Calcium formate (155 mg/1) + Iron Dextran (65 mg/1) + Niacin (25 mg/1) + Niacin (25 mg/1) + Calcium pantothenate (300 ug/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Riboflavin sodium (5 mg/1) + Riboflavin (5 mg/1) + Succinic acid (150 mg/1) + Thiamine hydrochloride (5 mg/1) + Thiamine hydrochloride (5 mg/1)	Kit		WOMENS CHOICE PHARMACEUTICALS LLC	2011-04-15	Not applicable
Multi Vitamin with Fluoride	Sodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.5 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)	Tablet, chewable	Oral	Qualitest	2009-10-09	2014-12-31
Multi Vitamin with Fluoride	Sodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (1 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)	Tablet, chewable	Oral	Physicians Total Care, Inc.	2003-06-04	2013-01-15
Multi Vitamin with Fluoride	Sodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.25 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)	Tablet, chewable	Oral	Qualitest	2009-10-09	2014-08-31
Multi Vitamin with Fluoride	Sodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.5 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)	Tablet, chewable	Oral	Physicians Total Care, Inc.	2003-09-08	2013-01-15
Multi Vitamin with Fluoride	Sodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.25 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)	Tablet, chewable	Oral	Physicians Total Care, Inc.	2003-09-05	2013-01-15
Multi Vitamin with Fluoride	Sodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.5 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)	Tablet, chewable	Oral	A S Medication Solutions	2009-10-09	Not applicable
Multi Vitamin with Fluoride	Sodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (1 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)	Tablet, chewable	Oral	Qualitest	2009-10-09	2014-12-31

Categories

• Acids, Acyclic
• Antioxidants
• Carbohydrates
• Compounds used in a research, industrial, or household setting
• Diet, Food, and Nutrition
• Food
• Food and Beverages
• Growth Substances
• Hydroxy Acids
• Laxatives
• Micronutrients
• Osmotic Laxatives
• Physiological Phenomena
• Protective Agents
• Sugar Acids
• Urinary Acidifying Agents
• Vitamin C and analogues
• Vitamins

UNII

S033EH8359

CAS number

134-03-2

Weight

Average: 198.106
Monoisotopic: 198.01403223

Chemical Formula

C₆H₇NaO₆

InChI Key

PPASLZSBLFJQEF-RXSVEWSESA-M

InChI

InChI=1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1

IUPAC Name

sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate

SMILES

[Na+].[H][C@@]1(OC(=O)C(O)=C1[O-])[C@@H](O)CO

Pharmacology

Indication

Not Available

Associated Therapies

• Dietary and Nutritional Therapies

Pharmacodynamics

Not Available

Mechanism of action

Not Available

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Additional Data Available

Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available

Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available

Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half life

Not Available

Clearance

Not Available

Toxicity

Not Available

Affected organisms

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

• All Drugs
• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental

Drug	Interaction
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2,5-Dimethoxy-4-ethylamphetamine	The serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when it is combined with Sodium ascorbate.
2,5-Dimethoxy-4-ethylthioamphetamine	The serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when it is combined with Sodium ascorbate.
4-Bromo-2,5-dimethoxyamphetamine	The serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when it is combined with Sodium ascorbate.
Acetazolamide	The risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium ascorbate.
Aclidinium	The therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Aclidinium.
Agmatine	The therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Agmatine.
Alfentanil	The therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Alfentanil.
Almasilate	The therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Almasilate.
Aloglutamol	The therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Aloglutamol.
Alphacetylmethadol	The therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Alphacetylmethadol.

Additional Data Available

Extended Description
Extended Description
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Severity
Severity
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Evidence Level
Evidence Level
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Action
Action
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Food Interactions

Not Available

References

General References

Not Available

External Links

KEGG Drug

D05853

ChemSpider

16736174

ChEBI

113451

ChEMBL

CHEMBL591665

PharmGKB

PA166163262

Wikipedia

Sodium_ascorbate

AHFS Codes

• 88:12.00 — Vitamin C

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
0	Not Yet Recruiting	Prevention	Open Posterior Thoracolumbar Spinal Fusion Procedure	1
0	Recruiting	Basic Science	Arterial Stiffness / Vasodilation	1
1, 2	Recruiting	Treatment	Lung Cancer Non-Small Cell Cancer (NSCLC)	1
1, 2	Withdrawn	Treatment	Malignant Neoplasm of Pancreas / Pancreatic Adenocarcinoma Resectable / Pancreatic Cancer Metastatic / Pancreatic Ductal Adenocarcinoma / Pancreatic Metastasis	2
1, 2	Withdrawn	Treatment	Pancreatic Cancer Metastatic	1
2	Not Yet Recruiting	Treatment	Neoplasms, Pancreatic	1
2	Recruiting	Treatment	Alcoholic Hepatitis (AH) / Sepsis	1
2	Recruiting	Treatment	Leukemia, Lymphocytic / Lymphoma, Hodgkins / Monocytic Leukemia / Multiple Myeloma (MM) / Myelodysplasia / Myeloid Leukemias / Non Hodgkin Lymphoma (NHL)	1
2	Recruiting	Treatment	Malignant Lymphomas / Myeloma Multiple	1
2	Recruiting	Treatment	Sepsis / Shock, Septic	1
3	Not Yet Recruiting	Prevention	Abdominal Hysterectomy	1
3	Not Yet Recruiting	Treatment	Shock, Septic	1
3	Recruiting	Treatment	Anemias / Iron Deficiency Anemia (IDA)	1
3	Recruiting	Treatment	Intensive Care Units / Sepsis / Vitamin c	1
3	Recruiting	Treatment	Sepsis / Shock, Septic	1
4	Active Not Recruiting	Diagnostic	Colon Adenomas / Colon Lesion / Colon Polyps	1
4	Recruiting	Prevention	Aging / Inflammatory Reaction	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage forms

Form	Route	Strength
Wafer	Oral	500 mg
Solution	Intravenous	250 mg
Powder, for solution	Oral
Tablet, chewable	Oral
Tablet	Oral	250 mg
Tablet, film coated	Oral
Kit
Liquid	Oral
Powder	Oral
Capsule, gelatin coated	Oral
Powder	Oral	888.8 mg
Capsule	Oral
Tablet	Oral	50 mg
Tablet, coated	Oral
Liquid	Intramuscular; Intravenous	250 mg
Tablet	Oral	60 mg
Lozenge	Oral
Tablet	Oral

Prices

Not Available

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
Unlock Additional Data
US7169381	No	2007-01-30	2024-09-01
US7658914	No	2010-02-09	2024-09-01
US9326969	No	2016-05-03	2033-09-10
US9592252	No	2017-03-14	2032-08-11
US9707297	No	2017-07-18	2033-09-10
US8999313	No	2015-04-07	2033-09-10
US10016504	No	2018-07-10	2033-09-10

Additional Data Available

Filed On
Filed On
The date on which a patent was filed with the relevant government.
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Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	625.0 mg/mL	ALOGPS
logP	-1.4	ALOGPS
logP	-1.9	ChemAxon
logS	0.5	ALOGPS
pKa (Strongest Acidic)	4.36	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	110.05 Å2	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	47.58 m3·mol-1	ChemAxon
Polarizability	14.51 Å3	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Not Available

Taxonomy

Description

This compound belongs to the class of organic compounds known as butenolides. These are dihydrofurans with a carbonyl group at the C2 carbon atom.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Dihydrofurans

Sub Class

Furanones

Direct Parent

Butenolides

Alternative Parents

Vinylogous acids / Enoate esters / Secondary alcohols / Lactones / 1,2-diols / Oxacyclic compounds / Monocarboxylic acids and derivatives / Primary alcohols / Organic zwitterions / Organic sodium saltsOrganic oxides / Hydrocarbon derivatives / Carbonyl compounds

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Substituents

2-furanone / Enoate ester / Alpha,beta-unsaturated carboxylic ester / Vinylogous acid / 1,2-diol / Carboxylic acid ester / Lactone / Secondary alcohol / Monocarboxylic acid or derivatives / Carboxylic acid derivativeOxacycle / Organic alkali metal salt / Hydrocarbon derivative / Organic oxide / Organic zwitterion / Organic oxygen compound / Primary alcohol / Organooxygen compound / Alcohol / Carbonyl group / Organic salt / Organic sodium salt / Aliphatic heteromonocyclic compound

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Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

Not Available

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Drug created on July 06, 2018 16:02 / Updated on July 16, 2019 06:23