Magnesium levulinate

Identification

Summary

Magnesium levulinate is a supplement to treat magnesium deficiency.

Generic Name
Magnesium levulinate
DrugBank Accession Number
DB14514
Background

Not Available

Type
Small Molecule
Groups
Nutraceutical
Structure
Weight
Average: 254.521
Monoisotopic: 254.06407987
Chemical Formula
C10H14MgO6
Synonyms
  • Magnesium diasporal

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
USodium/potassium-transporting ATPase subunit alpha-1Not AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
Alendronic acidMagnesium levulinate can cause a decrease in the absorption of Alendronic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
AlfacalcidolThe serum concentration of Magnesium levulinate can be increased when it is combined with Alfacalcidol.
AmiodaroneThe risk or severity of hypotension can be increased when Magnesium levulinate is combined with Amiodarone.
AmlodipineThe risk or severity of hypotension can be increased when Magnesium levulinate is combined with Amlodipine.
BepridilThe risk or severity of hypotension can be increased when Magnesium levulinate is combined with Bepridil.
Food Interactions
Not Available

Products

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Categories

ATC Codes
A12CC07 — Magnesium levulinate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as gamma-keto acids and derivatives. These are organic compounds containing an aldehyde substituted with a keto group on the C4 carbon atom.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Keto acids and derivatives
Sub Class
Gamma-keto acids and derivatives
Direct Parent
Gamma-keto acids and derivatives
Alternative Parents
Short-chain keto acids and derivatives / Ketones / Carboxylic acid salts / Monocarboxylic acids and derivatives / Carboxylic acids / Organic salts / Organic oxides / Hydrocarbon derivatives / Organic cations
Substituents
Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Carboxylic acid derivative / Carboxylic acid salt / Gamma-keto acid / Hydrocarbon derivative / Ketone / Monocarboxylic acid or derivatives / Organic cation
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
DU3I0H5Z4H
CAS number
58505-81-0
InChI Key
RECCGACJWKEPOU-UHFFFAOYSA-L
InChI
InChI=1S/2C5H8O3.Mg/c2*1-4(6)2-3-5(7)8;/h2*2-3H2,1H3,(H,7,8);/q;;+2/p-2
IUPAC Name
magnesium(2+) bis(4-oxopentanoate)
SMILES
[Mg++].CC(=O)CCC([O-])=O.CC(=O)CCC([O-])=O

References

General References
  1. DIMDI: Magnesium Diasporal (Magnesium Levulinate) Oral Granule [Link]
ChemSpider
9761676
ChEMBL
CHEMBL3707302
Wikipedia
Magnesium_levulinate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
GranuleOral300 MG
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility1.22 mg/mLALOGPS
logP0.82ALOGPS
logP-0.069Chemaxon
logS-2.3ALOGPS
pKa (Strongest Acidic)4.32Chemaxon
pKa (Strongest Basic)-7.3Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area57.2 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity37.93 m3·mol-1Chemaxon
Polarizability10.79 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Targets

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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Steroid hormone binding
Specific Function
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates th...
Gene Name
ATP1A1
Uniprot ID
P05023
Uniprot Name
Sodium/potassium-transporting ATPase subunit alpha-1
Molecular Weight
112895.01 Da
References
  1. Buchachenko AL, Kuznetsov DA, Berdinskii VL: [New mechanisms of biological effects of electromagnetic fields]. Biofizika. 2006 May-Jun;51(3):545-52. [Article]
  2. Sirijovski N, Olsson U, Lundqvist J, Al-Karadaghi S, Willows RD, Hansson M: ATPase activity associated with the magnesium chelatase H-subunit of the chlorophyll biosynthetic pathway is an artefact. Biochem J. 2006 Dec 15;400(3):477-84. [Article]
  3. Balasubramaniyan V, Nalini N: Leptin alters brain adenosine triphosphatase activity in ethanol-mediated neurotoxicity in mice. Singapore Med J. 2006 Oct;47(10):864-8. [Article]
  4. Nogovitsina OR, Levitina EV: Neurological aspects of the clinical features, pathophysiology, and corrections of impairments in attention deficit hyperactivity disorder. Neurosci Behav Physiol. 2007 Mar;37(3):199-202. [Article]

Drug created at July 12, 2018 16:20 / Updated at May 14, 2021 01:06