Magnesium lactate

Identification

Name
Magnesium lactate
Accession Number
DB14515  (DBSALT002535)
Type
Small Molecule
Groups
Nutraceutical
Description
Not Available
Structure
Thumb
Synonyms
  • Magnesium DL-lactate
  • Magnesium lactate anhydrous
  • Magnesium lactate, anhydrous
Categories
UNII
MT6QI8324A
CAS number
18917-93-6
Weight
Average: 200.429
Monoisotopic: 200.01712968
Chemical Formula
C6H8MgO6
InChI Key
VCCUEOJOYXPBRA-UHFFFAOYSA-L
InChI
InChI=1S/2C3H5O3.Mg/c2*1-2(4)3(5)6;/h2*2H,1H3,(H,5,6);/q2*-1;+4/p-2
IUPAC Name
lambda4-magnesium(4+) bis(2-oxidopropanoate)
SMILES
[Mg+4].CC([O-])C([O-])=O.CC([O-])C([O-])=O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
USodium/potassium-transporting ATPase subunit alpha-1Not AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AmlodipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Amlodipine is combined with Magnesium lactate.
CalcidiolThe serum concentration of Magnesium lactate can be increased when it is combined with Calcidiol.
CalcipotriolThe serum concentration of Magnesium lactate can be increased when it is combined with Calcipotriol.
CalcitriolThe serum concentration of Magnesium lactate can be increased when it is combined with Calcitriol.
CholecalciferolThe serum concentration of Magnesium lactate can be increased when it is combined with Cholecalciferol.
Clodronic AcidMagnesium lactate can cause a decrease in the absorption of Clodronic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
DiltiazemThe risk or severity of hypotension and neuromuscular blockade can be increased when Diltiazem is combined with Magnesium lactate.
DoxycyclineMagnesium lactate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
ErgocalciferolThe serum concentration of Magnesium lactate can be increased when it is combined with Ergocalciferol.
FelodipineThe risk or severity of hypotension and neuromuscular blockade can be increased when Felodipine is combined with Magnesium lactate.
Food Interactions
Not Available

References

General References
Not Available
External Links
Wikipedia
Magnesium_lactate
ATC Codes
A12CC06 — Magnesium lactate

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility15.7 mg/mLALOGPS
logP1.62ALOGPS
logP-0.47ChemAxon
logS-1.2ALOGPS
pKa (Strongest Acidic)3.78ChemAxon
pKa (Strongest Basic)-3.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area63.19 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity40.23 m3·mol-1ChemAxon
Polarizability7.31 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Steroid hormone binding
Specific Function
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates th...
Gene Name
ATP1A1
Uniprot ID
P05023
Uniprot Name
Sodium/potassium-transporting ATPase subunit alpha-1
Molecular Weight
112895.01 Da
References
  1. Buchachenko AL, Kuznetsov DA, Berdinskii VL: [New mechanisms of biological effects of electromagnetic fields]. Biofizika. 2006 May-Jun;51(3):545-52. [PubMed:16808357]
  2. Sirijovski N, Olsson U, Lundqvist J, Al-Karadaghi S, Willows RD, Hansson M: ATPase activity associated with the magnesium chelatase H-subunit of the chlorophyll biosynthetic pathway is an artefact. Biochem J. 2006 Dec 15;400(3):477-84. [PubMed:16928192]
  3. Balasubramaniyan V, Nalini N: Leptin alters brain adenosine triphosphatase activity in ethanol-mediated neurotoxicity in mice. Singapore Med J. 2006 Oct;47(10):864-8. [PubMed:16990961]
  4. Nogovitsina OR, Levitina EV: Neurological aspects of the clinical features, pathophysiology, and corrections of impairments in attention deficit hyperactivity disorder. Neurosci Behav Physiol. 2007 Mar;37(3):199-202. [PubMed:17294093]

Drug created on July 12, 2018 10:21 / Updated on August 02, 2018 07:05