Ceftobiprole medocaril

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Ceftobiprole medocaril
Accession Number
DB14733
Type
Small Molecule
Groups
Experimental, Investigational
Description

Ceftobiprole medocaril is a ceftobiprole prodrug.

Structure
Thumb
Synonyms
  • Ceftobiprole medocaril
  • Ceftobiprole medocaril free acid
Product Ingredients
IngredientUNIICASInChI Key
Ceftobiprole medocaril sodiumN99027V28J252188-71-9MFAWUGGPPMTWPU-LCJFHXTKSA-M
Categories
UNII
YXV28V1B07
CAS number
376653-43-9
Weight
Average: 690.66
Monoisotopic: 690.116246037
Chemical Formula
C26H26N8O11S2
InChI Key
HFTSMHTWUFCYMJ-YIOMYIDASA-N
InChI
InChI=1S/C26H26N8O11S2/c1-10-14(45-26(41)44-10)8-43-25(40)32-4-3-13(7-32)33-5-2-11(20(33)36)6-12-9-46-22-16(21(37)34(22)17(12)23(38)39)28-19(35)15(30-42)18-29-24(27)47-31-18/h6,13,16,22,42H,2-5,7-9H2,1H3,(H,28,35)(H,38,39)(H2,27,29,31)/b11-6+,30-15-/t13-,16-,22-/m1/s1
IUPAC Name
(6R,7R)-7-[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(N-hydroxyimino)acetamido]-3-{[(3E,3'R)-1'-{[(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methoxy]carbonyl}-2-oxo-[1,3'-bipyrrolidin]-3-ylidene]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
SMILES
[H][C@@]1(NC(=O)C(=N/O)\C2=NSC(N)=N2)C(=O)N2C(C(O)=O)=C(CS[C@]12[H])\C=C1/CCN(C1=O)[C@]1([H])CCN(C1)C(=O)OCC1=C(C)OC(=O)O1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
(R)-warfarinThe risk or severity of bleeding can be increased when Ceftobiprole medocaril is combined with (R)-warfarin.
(S)-WarfarinThe risk or severity of bleeding can be increased when Ceftobiprole medocaril is combined with (S)-Warfarin.
4-hydroxycoumarinThe risk or severity of bleeding can be increased when Ceftobiprole medocaril is combined with 4-hydroxycoumarin.
AcenocoumarolThe risk or severity of bleeding can be increased when Ceftobiprole medocaril is combined with Acenocoumarol.
BCG vaccineThe therapeutic efficacy of BCG vaccine can be decreased when used in combination with Ceftobiprole medocaril.
ClorindioneThe risk or severity of bleeding can be increased when Ceftobiprole medocaril is combined with Clorindione.
CoumarinThe risk or severity of bleeding can be increased when Ceftobiprole medocaril is combined with Coumarin.
DicoumarolThe risk or severity of bleeding can be increased when Ceftobiprole medocaril is combined with Dicoumarol.
DiphenadioneThe risk or severity of bleeding can be increased when Ceftobiprole medocaril is combined with Diphenadione.
Ethyl biscoumacetateThe risk or severity of bleeding can be increased when Ceftobiprole medocaril is combined with Ethyl biscoumacetate.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
28475342
ChEBI
135968
Wikipedia
Ceftobiprole
ATC Codes
J01DI01 — Ceftobiprole medocaril

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1RecruitingTreatmentBacterial Infections1
2RecruitingTreatmentInflamed Meninges / Suspected Meningitis / Ventriculitis1
2WithdrawnTreatmentBacteremia1
3CompletedTreatmentPneumonia1
3CompletedTreatmentSkin Diseases, Bacterial / Skin Diseases, Infectious / Staphylococcal Skin Infections2
3CompletedTreatmentAcute acute bacterial skin and skin structure infections1
3RecruitingTreatmentCommunity Acquired Pneumonia (CAP) / Pneumonia, Hospital-Acquired1
3RecruitingTreatmentStaphylococcus Aureus Bacteraemia1
3TerminatedTreatmentFevers / Infections, Gram-Positive Bacterial / Neutropenia / Pseudomonas Infections1
Not AvailableNot Yet RecruitingNot AvailableHepatic Insufficiency / Immunosuppression / Impaired kidney function1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.131 mg/mLALOGPS
logP0.16ALOGPS
logP-0.97ChemAxon
logS-3.7ALOGPS
pKa (Strongest Acidic)3.19ChemAxon
pKa (Strongest Basic)0.43ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count13ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area256.48 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity163.59 m3·mol-1ChemAxon
Polarizability64.88 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on January 27, 2019 14:57 / Updated on November 02, 2019 04:44