Fluoromisonidazole F-18

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Fluoromisonidazole F-18
Accession Number
DB14830
Type
Small Molecule
Groups
Investigational
Description

Fluoromisonidazole F-18 is under investigation in clinical trial NCT01507428 (Study of Positron Emission Tomography and Computed Tomography in Guiding Radiation Therapy in Patients With Stage III Non-small Cell Lung Cancer).

Structure
Thumb
Synonyms
  • 18F-MISO
Categories
Not Available
UNII
8MSY49469G
CAS number
104613-87-8
Weight
Average: 188.149
Monoisotopic: 188.057503797
Chemical Formula
C6H8FN3O3
InChI Key
HIIJZYSUEJYLMX-JZRMKITLSA-N
InChI
InChI=1S/C6H8FN3O3/c7-3-5(11)4-9-2-1-8-6(9)10(12)13/h1-2,5,11H,3-4H2/i7-1
IUPAC Name
1-(¹⁸F)fluoro-3-(2-nitro-1H-imidazol-1-yl)propan-2-ol
SMILES
OC(C[18F])CN1C=CN=C1[N+]([O-])=O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
396524
ChEMBL
CHEMBL2037002

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingDiagnosticSquamous Cell Carcinoma of the Head and Neck (SCCHN)1
2Active Not RecruitingTreatmentStage III Lung Non-Small Cell Cancer AJCC v7 / Stage III Non-Small Cell Lung Cancer / Stage III Non-Small Cell Lung Cancer AJCC v7 / Stage IIIA Lung Non-Small Cell Cancer AJCC v7 / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIA Non-Small Cell Lung Cancer AJCC v7 / Stage IIIB Lung Non-Small Cell Cancer AJCC v7 / Stage IIIb Non-small Cell Lung Cancer / Stage IIIB Non-Small Cell Lung Cancer AJCC v71
2CompletedDiagnosticAdult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma1
2CompletedDiagnosticAdult Liver Carcinoma / Liver Cirrhosis1
2WithdrawnDiagnosticMelanoma / Skin Cancers1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility5.39 mg/mLALOGPS
logP-0.46ALOGPS
logP0.27ChemAxon
logS-1.6ALOGPS
pKa (Strongest Acidic)13.64ChemAxon
pKa (Strongest Basic)0.001ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area81.19 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity40.27 m3·mol-1ChemAxon
Polarizability15.65 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on May 20, 2019 08:29 / Updated on May 21, 2019 12:29