Filgotinib

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Logo pink
Are you a
new drug developer?
Contact us to learn more about our customized products and solutions.
Logo pink
Stay in the know!
As part of our commitment to providing the most up-to-date drug information, we will be releasing #DrugBankUpdates with our newly added curated drug pages.
#DrugBankUpdates
Name
Filgotinib
Accession Number
DB14845
Type
Small Molecule
Groups
Investigational
Description

Filgotinib is under investigation in clinical trial NCT03100942 (Safety and Efficacy Study of Filgotinib, Lanraplenib and Tirabrutinib in Adults With Active Sjogren's Syndrome).

Structure
Thumb
Synonyms
Not Available
Categories
UNII
3XVL385Q0M
CAS number
1206161-97-8
Weight
Average: 425.51
Monoisotopic: 425.152160795
Chemical Formula
C21H23N5O3S
InChI Key
RIJLVEAXPNLDTC-UHFFFAOYSA-N
InChI
InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
IUPAC Name
N-(5-{4-[(1,1-dioxo-1lambda6-thiomorpholin-4-yl)methyl]phenyl}-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide
SMILES
O=C(NC1=NN2C(C=CC=C2C2=CC=C(CN3CCS(=O)(=O)CC3)C=C2)=N1)C1CC1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
28189566
BindingDB
103727
ChEMBL
CHEMBL3301607
PDBe Ligand
2HB
Wikipedia
Filgotinib
PDB Entries
4p7e / 5ut5

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentCrohn's Disease (CD) / Rheumatoid Arthritis / Ulcerative Colitis1
2Active Not RecruitingTreatmentPsoriatic Arthritis1
2Active Not RecruitingTreatmentRheumatoid Arthritis1
2CompletedTreatmentAnkylosing Spondylitis (AS)1
2CompletedTreatmentCutaneous Lupus Erythematosus (CLE)1
2CompletedTreatmentLupus Membranous Nephropathy1
2CompletedTreatmentPsoriatic Arthritis1
2CompletedTreatmentRheumatoid Arthritis1
2CompletedTreatmentSjögren's Syndrome1
2RecruitingTreatmentAnkylosing Spondylitis (AS) / Non-Radiographical Axial Spondyloarthritis / Psoriatic Arthritis / Rheumatoid Arthritis1
2RecruitingTreatmentFistulizing Crohn's Disease1
2RecruitingTreatmentInflammatory Bowel Diseases (IBD) / Ulcerative Colitis1
2RecruitingTreatmentNon-Infectious Uveitis / Noninfectious Uveitis1
2RecruitingTreatmentSmall Bowel Crohn's Disease1
3Active Not RecruitingTreatmentRheumatoid Arthritis1
3Active Not RecruitingTreatmentUlcerative Colitis1
3CompletedTreatmentRheumatoid Arthritis3
3Enrolling by InvitationTreatmentCrohn's Disease (CD)1
3Enrolling by InvitationTreatmentUlcerative Colitis1
3RecruitingTreatmentCrohn's Disease (CD)1
3RecruitingTreatmentPsoriatic Arthritis2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.177 mg/mLALOGPS
logP1.99ALOGPS
logP2.03ChemAxon
logS-3.4ALOGPS
pKa (Strongest Acidic)10.96ChemAxon
pKa (Strongest Basic)3.32ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area96.67 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity126.12 m3·mol-1ChemAxon
Polarizability44.72 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on May 20, 2019 08:30 / Updated on February 02, 2020 03:17