Pimodivir

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Pimodivir
Accession Number
DB14974
Description

Pimodivir is under investigation in clinical trial NCT02658825 (A Study to Evaluate the Effect of JNJ-63623872 on Cardiac Repolarization Interval in Healthy Participants).

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 399.402
Monoisotopic: 399.150681198
Chemical Formula
C20H19F2N5O2
Synonyms
  • JNJ-63623872

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Categories

Drug Categories
Not Available
Classification
Not classified

Chemical Identifiers

UNII
DFC121MXC3
CAS number
1629869-44-8
InChI Key
JGPXDNKSIXAZEQ-SBBZOCNPSA-N
InChI
InChI=1S/C20H19F2N5O2/c21-11-5-12-13(7-24-17(12)23-6-11)18-25-8-14(22)19(27-18)26-16-10-3-1-9(2-4-10)15(16)20(28)29/h5-10,15-16H,1-4H2,(H,23,24)(H,28,29)(H,25,26,27)/t9?,10?,15-,16-/m0/s1
IUPAC Name
(2S,3S)-3-[(5-fluoro-2-{5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl}pyrimidin-4-yl)amino]bicyclo[2.2.2]octane-2-carboxylic acid
SMILES
OC(=O)[C@H]1C2CCC(CC2)[C@@H]1NC1=C(F)C=NC(=N1)C1=CNC2=C1C=C(F)C=N2

References

General References
Not Available
ChemSpider
58136671
BindingDB
50050712
ChEMBL
CHEMBL3318007
ZINC
ZINC000098208077
Wikipedia
Pimodivir

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3RecruitingTreatmentInfluenza A Virus Infection2
2CompletedTreatmentInfluenza A Virus1
1CompletedNot AvailableHealthy Volunteers2
1CompletedOtherHealthy Volunteers1
1CompletedOtherHepatic Impairment1
1CompletedTreatmentHealthy Volunteers5
1CompletedTreatmentInfluenza A Virus1
1CompletedTreatmentInfluenza in Humans1
1RecruitingOtherChronic Renal Failure (CRF)1
Not AvailableAvailableNot AvailableH7N9 Subtype of Influenza A Virus1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0384 mg/mLALOGPS
logP3.07ALOGPS
logP3.27ChemAxon
logS-4ALOGPS
pKa (Strongest Acidic)4.2ChemAxon
pKa (Strongest Basic)2.57ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area103.79 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity112.27 m3·mol-1ChemAxon
Polarizability38.46 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on May 20, 2019 08:38 / Updated on June 12, 2020 10:53

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