Voxelotor

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Voxelotor
Accession Number
DB14975
Type
Small Molecule
Groups
Investigational
Description

Voxelotor is under investigation in clinical trial NCT03114540 (Single-Dose PK and Safety Study of GBT440 in Subjects With Hepatic Impairment).

Structure
Thumb
Synonyms
Not Available
External IDs
GBT440
Categories
UNII
3ZO554A4Q8
CAS number
1446321-46-5
Weight
Average: 337.379
Monoisotopic: 337.142641484
Chemical Formula
C19H19N3O3
InChI Key
FWCVZAQENIZVMY-UHFFFAOYSA-N
InChI
InChI=1S/C19H19N3O3/c1-13(2)22-16(8-10-21-22)19-14(5-4-9-20-19)12-25-18-7-3-6-17(24)15(18)11-23/h3-11,13,24H,12H2,1-2H3
IUPAC Name
SMILES
CC(C)N1N=CC=C1C1=C(COC2=CC=CC(O)=C2C=O)C=CC=N1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
Calcium carbimideThe risk or severity of adverse effects can be increased when Calcium carbimide is combined with Voxelotor.
DisulfiramThe risk or severity of adverse effects can be increased when Disulfiram is combined with Voxelotor.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
37999268
ChEMBL
CHEMBL4101807
Wikipedia
Voxelotor

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedOtherHepatic Impairment1
1CompletedOtherImpaired Renal Function1
1CompletedOtherSickle Cell Disorders1
1CompletedTreatmentHealthy Volunteers / Sickle Cell Disorders1
1CompletedTreatmentSickle Cell Disorders2
1TerminatedOtherCardio-pulmonary Function1
2CompletedOtherSickle Cell Disorders1
2CompletedSupportive CareIdiopathic Pulmonary Fibrosis (IPF)1
2RecruitingTreatmentSickle Cell Disorders1
2TerminatedSupportive CareIdiopathic Pulmonary Fibrosis (IPF)1
3Active Not RecruitingTreatmentSickle Cell Disorders1
3Enrolling by InvitationTreatmentSickle Cell Disorders1
Not AvailableAvailableNot AvailableSickle Cell Disorders1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on May 20, 2019 08:39 / Updated on May 21, 2019 12:32