Umbralisib

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Umbralisib
Accession Number
DB14989
Type
Small Molecule
Groups
Investigational
Description

Umbralisib is under investigation in clinical trial NCT02535286 (Study of Immunotherapy in Combination With Ublituximab and Umbralisib in Patients With Relapsed-refractory CLL or Richter's Transformation).

Structure
Thumb
Synonyms
Not Available
External IDs
TGR-1202
Categories
Not Available
UNII
38073MQB2A
CAS number
1532533-67-7
Weight
Average: 571.56
Monoisotopic: 571.183124142
Chemical Formula
C31H24F3N5O3
InChI Key
IUVCFHHAEHNCFT-INIZCTEOSA-N
InChI
InChI=1S/C31H24F3N5O3/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29/h4-16H,1-3H3,(H2,35,36,37)/t16-/m0/s1
IUPAC Name
SMILES
CC(C)OC1=C(F)C=C(C=C1)C1=NN([C@@H](C)C2=C(C3=CC=CC(F)=C3)C(=O)C3=CC(F)=CC=C3O2)C2=C1C(N)=NC=N2

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
34979945
BindingDB
184556
ChEMBL
CHEMBL3948730
Wikipedia
Umbralisib

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingTreatmentChronic Lymphocytic Leukaemia (CLL) / Lymphoma, Hodgkins / Non-Hodgkin's Lymphoma (NHL) / Peripheral T-Cell Lymphoma (PTCL)1
1Active Not RecruitingTreatmentChronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma / Mantle Cell Lymphoma (MCL)1
1Active Not RecruitingTreatmentColorectal Cancers / Esophageal Cancers / Gastrointestinal Stromal Tumors (GISTs) / Malignant Neoplasm of Pancreas / Malignant Neoplasm of Stomach / Rectal Carcinoma1
1RecruitingTreatmentAgnogenic Myeloid Metaplasia / Polycythemia Vera (PV)1
1RecruitingTreatmentB-cell Non Hodgkin's Lymphoma / Chronic Lymphocytic Leukaemia (CLL)1
1RecruitingTreatmentChronic Lymphocytic Leukaemia (CLL) / Non Hodgkin Lymphoma (NHL)1
1, 2RecruitingTreatmentChronic Lymphocytic Leukaemia (CLL)1
1, 2RecruitingTreatmentChronic Lymphocytic Leukaemia (CLL) / Richter's Syndrome1
1, 2RecruitingTreatmentHodgkins Disease (HD) / Non-Hodgkin's Lymphoma (NHL)1
2Active Not RecruitingTreatmentChronic Lymphocytic Leukaemia (CLL)1
2Active Not RecruitingTreatmentRecurrent Diffuse Large B-Cell Lymphoma / Refractory Diffuse Large B Cell Lymphoma1
2Enrolling by InvitationTreatmentChronic Lymphocytic Leukaemia (CLL) / Non Hodgkin Lymphoma (NHL)1
2Not Yet RecruitingTreatmentFollicular Lymphoma (FL) / Follicular Lymphoma Grade 2 / Follicular Lymphoma Grade IIIa / Follicular Lymphoma, Grade 1 / Malignant Lymphomas / Marginal Zone B Cell Lymphoma / Marginal Zone Lymphoma1
2Not Yet RecruitingTreatmentFollicular Lymphoma (FL) / Small Lymphocytic Lymphoma (SLL)1
2Not Yet RecruitingTreatmentLymphoma, Hodgkins1
2RecruitingTreatmentChronic Lymphocytic Leukaemia (CLL)2
2RecruitingTreatmentFollicular Lymphoma (FL)1
2RecruitingTreatmentGrade 1 Follicular Lymphoma / Grade 2 Follicular Lymphoma / Grade 3a Follicular Lymphoma / Recurrent Follicular Lymphoma / Refractory Follicular Lymphoma1
2RecruitingTreatmentMarginal Zone Lymphoma / Waldenström's Macroglobulinemia (WM)1
2, 3RecruitingTreatmentFollicular Lymphoma (FL) / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Mantle Cell Lymphoma (MCL) / Marginal Zone Lymphoma / Small Lymphocytic Lymphoma (SLL)1
3Active Not RecruitingTreatmentChronic Lymphocytic Leukaemia (CLL)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on May 20, 2019 08:39 / Updated on May 21, 2019 12:33