NAV

BMS-919373

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
BMS-919373
DrugBank Accession Number
DB15047
Background

BMS-919373 is under investigation in clinical trial NCT02153437 (Study of the Effects of BMS-919373 on the Electrical Activity of the Heart Using Pacemakers).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 468.54
Monoisotopic: 468.136845082
Chemical Formula
C25H20N6O2S
Synonyms
Not Available
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
NGB50MQK8N
CAS number
1272353-82-8
InChI Key
XGKULQQVQWCASY-UHFFFAOYSA-N
InChI
InChI=1S/C25H20N6O2S/c26-34(32,33)20-13-18(14-27-16-20)24-30-22-11-6-10-21(17-7-2-1-3-8-17)23(22)25(31-24)29-15-19-9-4-5-12-28-19/h1-14,16H,15H2,(H2,26,32,33)(H,29,30,31)
IUPAC Name
5-(5-phenyl-4-{[(pyridin-2-yl)methyl]amino}quinazolin-2-yl)pyridine-3-sulfonamide
SMILES
NS(=O)(=O)C1=CN=CC(=C1)C1=NC(NCC2=NC=CC=C2)=C2C(C=CC=C2C2=CC=CC=C2)=N1

References

General References
Not Available
ChemSpider
38000270
BindingDB
50239227
ChEMBL
CHEMBL4094440
ZINC
ZINC000116369258

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2TerminatedOtherParoxysmal Atrial Fibrillation (PAF)1
1CompletedNot AvailableAcute Coronary Syndrome (ACS)1
1TerminatedBasic ScienceAtrial Fibrillation1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00219 mg/mLALOGPS
logP3.65ALOGPS
logP3.71Chemaxon
logS-5.3ALOGPS
pKa (Strongest Acidic)9.29Chemaxon
pKa (Strongest Basic)4.42Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count7Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area123.75 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity141.79 m3·mol-1Chemaxon
Polarizability47.97 Å3Chemaxon
Number of Rings5Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-014i-1000900000-a23764878f0be27d6710
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-014i-0000900000-b137ad8422f12d14384d
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udr-0005900000-2fd267717f4553600faf
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-03fr-9006400000-f8dff2e66c1984d25ee0
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-03yr-1129200000-70c2af23b7036e4f109b
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9001100000-bfdf8c7218243975c626
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at May 20, 2019 14:44 / Updated at June 12, 2020 16:53