Omidenepag isopropyl

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Omidenepag isopropyl
Accession Number
DB15071
Description

Omidenepag isopropyl is under investigation in clinical trial NCT02179008 (Multi-center Phase II Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension).

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 520.61
Monoisotopic: 520.18927458
Chemical Formula
C26H28N6O4S
Synonyms
Not Available
External IDs
  • DE-117

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Categories

Drug Categories
Not Available
Classification
Not classified

Chemical Identifiers

UNII
G0G0H52U6K
CAS number
1187451-19-9
InChI Key
VIQCWEGEHRBLAC-UHFFFAOYSA-N
InChI
InChI=1S/C26H28N6O4S/c1-20(2)36-26(33)17-28-25-8-3-6-22(30-25)19-31(37(34,35)24-7-4-13-27-16-24)18-21-9-11-23(12-10-21)32-15-5-14-29-32/h3-16,20H,17-19H2,1-2H3,(H,28,30)
IUPAC Name
propan-2-yl 2-({6-[(N-{[4-(1H-pyrazol-1-yl)phenyl]methyl}pyridine-3-sulfonamido)methyl]pyridin-2-yl}amino)acetate
SMILES
CC(C)OC(=O)CNC1=CC=CC(CN(CC2=CC=C(C=C2)N2C=CC=N2)S(=O)(=O)C2=CC=CN=C2)=N1

References

General References
Not Available
ChemSpider
57643658

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Active Not RecruitingTreatmentGlaucoma and Ocular Hypertension2
3CompletedTreatmentOpen Angle Glaucoma or Ocular Hypertension2
3CompletedTreatmentPrimary Open Angle Glaucoma or Ocular Hypertension1
3RecruitingTreatmentGlaucoma, Primary Open Angle (POAG) / Primary Open-angle Glaucoma and Ocular Hypertension / Primary Open-Angle Glaucoma, Ocular Hypertension1
2CompletedTreatmentOcular Hypertension / Open-angle Glaucoma (OAG)1
2CompletedTreatmentOpen-angle Glaucoma or Ocular Hypertension1
2CompletedTreatmentOpen-angle Glaucoma, Ocular Hypertension / Primary Open-angle Glaucoma and Ocular Hypertension1
2, 3CompletedTreatmentGlaucoma, Primary Open Angle (POAG) / Ocular Hypertension1
1CompletedBasic ScienceHealthy Adult Male1
1, 2CompletedTreatmentGlaucoma and Ocular Hypertension1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0162 mg/mLALOGPS
logP3.08ALOGPS
logP2.67ChemAxon
logS-4.5ALOGPS
pKa (Strongest Basic)2.62ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area119.31 Å2ChemAxon
Rotatable Bond Count11ChemAxon
Refractivity141.29 m3·mol-1ChemAxon
Polarizability53.42 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on May 20, 2019 08:47 / Updated on June 12, 2020 10:53

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