AMG-232

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
AMG-232
Accession Number
DB15299
Type
Small Molecule
Groups
Investigational
Description

AMG-232 is under investigation in clinical trial NCT03041688 (MDM2 Inhibitor AMG-232 and Decitabine in Treating Patients With Relapsed, Refractory, or Newly-Diagnosed Acute Myeloid Leukemia).

Structure
Thumb
Synonyms
  • MDM2 INHIBITOR AMG-232
Categories
Not Available
UNII
7R7G6EH5UL
CAS number
1352066-68-2
Weight
Average: 568.55
Monoisotopic: 567.1612998
Chemical Formula
C28H35Cl2NO5S
InChI Key
DRLCSJFKKILATL-YWCVFVGNSA-N
InChI
InChI=1S/C28H35Cl2NO5S/c1-17(2)24(16-37(35,36)18(3)4)31-26(19-9-11-21(29)12-10-19)23(20-7-6-8-22(30)13-20)14-28(5,27(31)34)15-25(32)33/h6-13,17-18,23-24,26H,14-16H2,1-5H3,(H,32,33)/t23-,24-,26-,28-/m1/s1
IUPAC Name
2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2S)-3-methyl-1-(propane-2-sulfonyl)butan-2-yl]-2-oxopiperidin-3-yl]acetic acid
SMILES
CC(C)[C@@H](CS(=O)(=O)C(C)C)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)C1=CC=CC(Cl)=C1)C1=CC=C(Cl)C=C1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
31132728
BindingDB
50448947
ChEMBL
CHEMBL3125702

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Not Yet RecruitingTreatmentAcute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Leukemia Acute Myeloid Leukemia (AML)1
1RecruitingTreatmentAcute, recurrent Myeloid Leukemia / Blasts 20 Percent or More of Bone Marrow Nucleated Cells / Blasts 5 Percent or More of Bone Marrow Nucleated Cells / Leukemia Acute Myeloid Leukemia (AML) / Recurrent Adult Acute Myeloid Leukemia / Refractory Acute Myelogenous Leukemia (AML) / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / TP53 wt Allele / Untreated Adult Acute Myeloid Leukemia1
1RecruitingTreatmentGlioblastomas / Gliosarcoma / Recurrent Glioblastoma / TP53 wt Allele / Unmethylated MGMT Gene Promoter / Unmethylated MGMT Promoter1
1RecruitingTreatmentHypercalcemia / Plasmacytoma / Recurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma1
1RecruitingTreatmentSoft Tissue Sarcoma (STS)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000274 mg/mLALOGPS
logP4.27ALOGPS
logP5.86ChemAxon
logS-6.3ALOGPS
pKa (Strongest Acidic)4.19ChemAxon
pKa (Strongest Basic)-0.0047ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area91.75 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity146.04 m3·mol-1ChemAxon
Polarizability58.35 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on May 20, 2019 09:09 / Updated on February 02, 2020 03:22