Hydroquinidine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Hydroquinidine
Accession Number
DB15300
Type
Small Molecule
Groups
Investigational
Description

Hydroquinidine is under investigation in clinical trial NCT00927732 (Hydroquinidine Versus Placebo in Patients With Brugada Syndrome).

Structure
Thumb
Synonyms
Not Available
Categories
UNII
8P68XPY4HG
CAS number
1435-55-8
Weight
Average: 326.44
Monoisotopic: 326.199428085
Chemical Formula
C20H26N2O2
InChI Key
LJOQGZACKSYWCH-LHHVKLHASA-N
InChI
InChI=1S/C20H26N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h4-6,8,11,13-14,19-20,23H,3,7,9-10,12H2,1-2H3/t13-,14-,19+,20-/m0/s1
IUPAC Name
SMILES
CC[C@H]1C[N@@]2CC[C@H]1C[C@@H]2[C@@H](O)C1=C2C=C(OC)C=CC2=NC=C1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AcebutololAcebutolol may increase the arrhythmogenic activities of Hydroquinidine.
AcetyldigitoxinAcetyldigitoxin may increase the arrhythmogenic activities of Hydroquinidine.
AcetyldigoxinAcetyldigoxin may increase the arrhythmogenic activities of Hydroquinidine.
AdenosineAdenosine may increase the arrhythmogenic activities of Hydroquinidine.
AgmatineAgmatine may increase the arrhythmogenic activities of Hydroquinidine.
AjmalineAjmaline may increase the arrhythmogenic activities of Hydroquinidine.
AlprenololAlprenolol may increase the arrhythmogenic activities of Hydroquinidine.
AmiodaroneAmiodarone may increase the QTc-prolonging activities of Hydroquinidine.
AmlodipineAmlodipine may increase the arrhythmogenic activities of Hydroquinidine.
AnisodamineAnisodamine may increase the arrhythmogenic activities of Hydroquinidine.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
82624
ChEMBL
CHEMBL531472
Wikipedia
Dihydroquinidine
ATC Codes
C01BA13 — Hydroquinidine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3TerminatedTreatmentBrugada Syndrome1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on May 20, 2019 09:09 / Updated on May 21, 2019 12:40