Norleucine
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Norleucine
- DrugBank Accession Number
- DB15458
- Background
Norleucine is under investigation in clinical trial NCT00081952 (Amino Acid Therapy for Hot Flashes in Postmenopausal Women).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 131.1729
Monoisotopic: 131.094628665 - Chemical Formula
- C6H13NO2
- Synonyms
- L-NORLEUCINE
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 832C8OV84S
- CAS number
- 327-57-1
- InChI Key
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N
- InChI
- InChI=1S/C6H13NO2/c1-2-3-4-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)/t5-/m0/s1
- IUPAC Name
- (2S)-2-aminohexanoic acid
- SMILES
- CCCC[C@H](N)C(O)=O
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0001645
- KEGG Compound
- C01933
- ChemSpider
- 19964
- ChEBI
- 18347
- ChEMBL
- CHEMBL292439
- ZINC
- ZINC000001529322
- PDBe Ligand
- NLE
- Wikipedia
- Norleucine
- PDB Entries
- 1b7h / 1cfn / 1d5e / 1eol / 1f3r / 1fgl / 1hd9 / 1hth / 1jb6 / 1mmt … show 142 more
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1, 2 Completed Treatment Hot Flashes 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 89.2 mg/mL ALOGPS logP -1.7 ALOGPS logP -1.4 Chemaxon logS -0.17 ALOGPS pKa (Strongest Acidic) 2.79 Chemaxon pKa (Strongest Basic) 9.53 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 63.32 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 34.22 m3·mol-1 Chemaxon Polarizability 14.46 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 129.2279458 predictedDarkChem Lite v0.1.0 [M-H]- 131.3606585 predictedDarkChem Standard v0.1.0 [M-H]- 131.3300458 predictedDarkChem Lite v0.1.0 [M-H]- 125.530716 predictedDeepCCS 1.0 (2019) [M+H]+ 129.8768458 predictedDarkChem Lite v0.1.0 [M+H]+ 130.0776458 predictedDarkChem Lite v0.1.0 [M+H]+ 131.4827458 predictedDarkChem Lite v0.1.0 [M+H]+ 128.76984 predictedDeepCCS 1.0 (2019) [M+Na]+ 129.3569458 predictedDarkChem Lite v0.1.0 [M+Na]+ 129.4714458 predictedDarkChem Lite v0.1.0 [M+Na]+ 131.4542458 predictedDarkChem Lite v0.1.0 [M+Na]+ 137.43529 predictedDeepCCS 1.0 (2019)
Drug created at May 20, 2019 15:35 / Updated at June 12, 2020 16:53