NAV

FLX475

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
FLX475
DrugBank Accession Number
DB15570
Background

FLX475 is a small molecule CCR4 antagonist being investigated for the treatment of cancer.1

Type
Small Molecule
Groups
Investigational
Synonyms
Not Available
External IDs
  • FLX 475
  • FLX-475
  • FLX475
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
UC-C chemokine receptor type 4
antagonist
Humans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
Not Available
CAS number
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

References

General References
  1. NCI Drug Dictionary - Definition of CCR4 inhibitor FLX475 [Link]
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentGastric Cancer1
2TerminatedTreatmentAdvanced Melanoma1
1, 2Active Not RecruitingTreatmentAdvanced Malignant Neoplasm1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Targets

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Details1. C-C chemokine receptor type 4
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Antagonist
General Function
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Specific Function
C-c chemokine binding
Gene Name
CCR4
Uniprot ID
P51679
Uniprot Name
C-C chemokine receptor type 4
Molecular Weight
41402.385 Da
References
  1. NCI Drug Dictionary - Definition of CCR4 inhibitor FLX475 [Link]

Drug created at November 07, 2019 00:51 / Updated at June 12, 2020 16:53