Dihydromyricetin
Star1
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Dihydromyricetin
- DrugBank Accession Number
- DB15645
- Background
Dihydromyricetin is under investigation in clinical trial NCT03606694 (Effect of Dihydromirycetin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes Mellitus).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 320.251
Monoisotopic: 320.05321736 - Chemical Formula
- C15H12O8
- Synonyms
- (+)-ampelopsin
- (+)-dihydromyricetin
- Ampelopsin
- Ampeloptin
- Telocapil
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- KD8QND6427
- CAS number
- 27200-12-0
- InChI Key
- KJXSIXMJHKAJOD-LSDHHAIUSA-N
- InChI
- InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
- IUPAC Name
- (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
- SMILES
- O[C@@H]1[C@H](OC2=C(C(O)=CC(O)=C2)C1=O)C1=CC(O)=C(O)C(O)=C1
References
- General References
- Not Available
- External Links
- KEGG Compound
- C02906
- ChemSpider
- 141906
- BindingDB
- 212434
- ChEBI
- 28429
- ChEMBL
- CHEMBL3348861
- ZINC
- ZINC000100037633
- Wikipedia
- Ampelopsin
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Active Not Recruiting Treatment Type 2 Diabetes Mellitus 1 1 Not Yet Recruiting Treatment Alcohol Related Disorders 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 1.2 mg/mL ALOGPS logP 0.89 ALOGPS logP 1.51 Chemaxon logS -2.4 ALOGPS pKa (Strongest Acidic) 7.72 Chemaxon pKa (Strongest Basic) -4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 8 Chemaxon Hydrogen Donor Count 6 Chemaxon Polar Surface Area 147.68 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 76.59 m3·mol-1 Chemaxon Polarizability 29.2 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 186.9595564 predictedDarkChem Lite v0.1.0 [M-H]- 187.1635564 predictedDarkChem Lite v0.1.0 [M-H]- 172.09468 predictedDeepCCS 1.0 (2019) [M+H]+ 190.3345564 predictedDarkChem Lite v0.1.0 [M+H]+ 188.5811564 predictedDarkChem Lite v0.1.0 [M+H]+ 174.48413 predictedDeepCCS 1.0 (2019) [M+Na]+ 188.1295564 predictedDarkChem Lite v0.1.0 [M+Na]+ 187.4357564 predictedDarkChem Lite v0.1.0 [M+Na]+ 180.71432 predictedDeepCCS 1.0 (2019)
Drug created at March 23, 2020 20:14 / Updated at June 12, 2020 16:53