Warfarin sodiumProduct ingredient for Warfarin
- Name
- Warfarin sodium
- Drug Entry
- Warfarin
Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be noted when used medicinally, including its ability to cross the placental barrier during pregnancy which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death. Additional adverse effects such as necrosis, purple toe syndrome, osteoporosis, valve and artery calcification, and drug interactions have also been documented with warfarin use. Warfarin does not actually affect blood viscosity, rather, it inhibits vitamin-k dependent synthesis of biologically active forms of various clotting factors in addition to several regulatory factors.
- Accession Number
- DBSALT000278
- Structure
Structure for Warfarin sodium (DBSALT000278)
- Synonyms
- Not Available
- UNII
- 6153CWM0CL
- CAS Number
- 129-06-6
- Weight
- Average: 330.3098
Monoisotopic: 330.086803643 - Chemical Formula
- C19H15NaO4
- InChI Key
- KYITYFHKDODNCQ-UHFFFAOYSA-M
- InChI
- InChI=1S/C19H16O4.Na/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22;/h2-10,15,21H,11H2,1H3;/q;+1/p-1
- IUPAC Name
- sodium 2-oxo-3-(3-oxo-1-phenylbutyl)-2H-chromen-4-olate
- SMILES
- [Na+].CC(=O)CC(C1=CC=CC=C1)C1=C([O-])C2=CC=CC=C2OC1=O
- External Links
- Predicted Properties
Property Value Source Water Solubility 0.0219 mg/mL ALOGPS logP 3.46 ALOGPS logP 2.74 Chemaxon logS -4.2 ALOGPS pKa (Strongest Acidic) 5.56 Chemaxon pKa (Strongest Basic) -6.9 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 66.43 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 97.41 m3·mol-1 Chemaxon Polarizability 31.69 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon