Phenylpropanolamine hydrochlorideProduct ingredient for Phenylpropanolamine
- Name
- Phenylpropanolamine hydrochloride
- Drug Entry
- Phenylpropanolamine
Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes.
- Accession Number
- DBSALT000996
- Structure
Structure for Phenylpropanolamine hydrochloride (DBSALT000996)
- Synonyms
- Phenylpropanolamine HCl
- UNII
- 8D5I63UE1Q
- CAS Number
- 154-41-6
- Weight
- Average: 187.67
Monoisotopic: 187.0763918 - Chemical Formula
- C9H14ClNO
- InChI Key
- DYWNLSQWJMTVGJ-UHFFFAOYSA-N
- InChI
- InChI=1S/C9H13NO.ClH/c1-7(10)9(11)8-5-3-2-4-6-8;/h2-7,9,11H,10H2,1H3;1H
- IUPAC Name
- 2-amino-1-phenylpropan-1-ol hydrochloride
- SMILES
- Cl.CC(N)C(O)C1=CC=CC=C1
- External Links
- ChemSpider
- 8712
- ChEBI
- 31996
- ChEMBL
- CHEMBL1200695
- Wikipedia
- Phenylpropanolamine
- Predicted Properties
Property Value Source Water Solubility 20.6 mg/mL ALOGPS logP 0.57 ALOGPS logP 0.89 Chemaxon logS -0.87 ALOGPS pKa (Strongest Acidic) 13.9 Chemaxon pKa (Strongest Basic) 9.37 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 46.25 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 44.91 m3·mol-1 Chemaxon Polarizability 17 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon