Viloxazine hydrochlorideProduct ingredient for Viloxazine
- Name
- Viloxazine hydrochloride
- Drug Entry
- Viloxazine
Viloxazine is a selective norepinephrine reuptake inhibitor.7 For decades, an immediate-release formulation of viloxazine has been used in Europe as an antidepressant. It was first approved in the UK in 1974; however, the immediate-release formulation was discontinued due to business reasons unrelated to drug safety and efficacy. In the US, viloxazine was assigned an orphan drug designation in 1984 under the brand name CATATROL: while this product was intended to treat cataplexy and narcolepsy, the drug was never approved for these therapeutic indications. In April 2021, an extended-release formulation of viloxazine under the brand name QELBREE was approved by the FDA for the treatment of attention deficit hyperactivity disorder (ADHD).6
- Accession Number
- DBSALT001262
- Structure
- Synonyms
- Viloxazine HCl
- UNII
- OQW30I1332
- CAS Number
- 35604-67-2
- Weight
- Average: 273.76
Monoisotopic: 273.1131712 - Chemical Formula
- C13H20ClNO3
- InChI Key
- HJOCKFVCMLCPTP-UHFFFAOYSA-N
- InChI
- InChI=1S/C13H19NO3.ClH/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11;/h3-6,11,14H,2,7-10H2,1H3;1H
- IUPAC Name
- 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
- SMILES
- Cl.CCOC1=CC=CC=C1OCC1CNCCO1
- External Links
- ChemSpider
- 64514
- ChEMBL
- CHEMBL2106483
- Wikipedia
- Viloxazine
- Predicted Properties
Property Value Source Water Solubility 1.24 mg/mL ALOGPS logP 1.71 ALOGPS logP 1.49 Chemaxon logS -2.3 ALOGPS pKa (Strongest Basic) 8.19 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 39.72 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 65.2 m3·mol-1 Chemaxon Polarizability 26.2 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon