Remimazolam besylateProduct ingredient for Remimazolam
- Name
- Remimazolam besylate
- Drug Entry
- Remimazolam
Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures.6 Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid biotransformation and elimination as inactive metabolites.4 These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/offset is desirable, enabling anesthesiologists to manipulate drug concentrations as needed.3,4 Remimazolam was the first "soft" benzodiazepine analog to be developed5 and was approved for use by the FDA in July 2020 under the brand name Byfavo.7
- Accession Number
- DBSALT002953
- Structure
Structure for Remimazolam besylate (DBSALT002953)
- Synonyms
- Remimazolam besilate / Remimazolam besylate
- External IDs
- CNS 7056B / GW502056X / ONO-2745BS / ONO-IN-251 / RF10007 / SP148.5
- UNII
- 280XQ6482H
- CAS Number
- 1001415-66-2
- Weight
- Average: 597.48
Monoisotopic: 596.072904 - Chemical Formula
- C27H25BrN4O5S
- InChI Key
- QMTKNJZIWGTNTE-LMOVPXPDSA-N
- InChI
- InChI=1S/C21H19BrN4O2.C6H6O3S/c1-13-12-24-21-17(7-9-19(27)28-2)25-20(16-5-3-4-10-23-16)15-11-14(22)6-8-18(15)26(13)21;7-10(8,9)6-4-2-1-3-5-6/h3-6,8,10-12,17H,7,9H2,1-2H3;1-5H,(H,7,8,9)/t17-;/m0./s1
- IUPAC Name
- benzenesulfonic acid; methyl 3-[(7S)-12-bromo-3-methyl-9-(pyridin-2-yl)-2,5,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,8,10,12-hexaen-7-yl]propanoate
- SMILES
- OS(=O)(=O)C1=CC=CC=C1.COC(=O)CC[C@@H]1N=C(C2=NC=CC=C2)C2=CC(Br)=CC=C2N2C(C)=CN=C12
- External Links
- ChemSpider
- 30790854
- Wikipedia
- Remimazolam
- Predicted Properties
Property Value Source Water Solubility 0.0213 mg/mL ALOGPS logP 3.68 ALOGPS logP 3.75 Chemaxon logS -4.3 ALOGPS pKa (Strongest Basic) 5.61 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 69.37 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 119.71 m3·mol-1 Chemaxon Polarizability 43.08 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon