Protamine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Protamine is a heparin antagonist indicated in the treatment of heparin overdoses, to counteract heparins preoperatively, or during cardiac surgery and dialysis.

Generic Name
Protamine
DrugBank Accession Number
DB13700
Background

Not Available

Type
Small Molecule
Groups
Experimental, Investigational
Synonyms
  • Protamina

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Reversal ofHeparin overdose••••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Protamine hydrochloride5URD19Y60HNot AvailableNot applicable

Categories

ATC Codes
V03AB14 — Protamine
Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
72G3UY6T4N
CAS number
9012-00-4
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

References

General References
  1. TITCK Product Information: Protamine hydrochloride for intravenous administration [Link]
RxNav
8826
Wikipedia
Protamine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionAnticoagulation / Cardiopulmonary Bypass / Surgery, Cardiac1
4CompletedTreatmentAtrial Fibrillation / Catheter Ablation1
4CompletedTreatmentCoagulation; Intravascular1
4CompletedTreatmentType 2 Diabetes Mellitus1
4RecruitingPreventionValve Stenoses, Aortic1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
InjectionIntravenous5000 IU/5ml
Injection, solutionIntravenous1000 IU/ml
Injection, solutionIntravenous; Parenteral50 MG/5ML
SolutionIntravenous5000 IU
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at June 23, 2017 20:47 / Updated at May 29, 2021 18:12